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The map label for this gene is tyrB [H]

Identifier: 50083402

GI number: 50083402

Start: 113131

End: 114345

Strand: Reverse

Name: tyrB [H]

Synonym: ACIAD0112

Alternate gene names: 50083402

Gene position: 114345-113131 (Counterclockwise)

Preceding gene: 50083403

Following gene: 50083401

Centisome position: 3.18

GC content: 43.7

Gene sequence:

>1215_bases
ATGTTTCAACATATCCCACCGTATGCGGGCGATCCAATCTTGTCGCTTATGGAACAATTCAACGCCGATTCACGCGAAGC
GAAAGTTAATTTGAGCATTGGTCTTTATTATAATGAAGACAGTATTGTGCCTCAGCTTGACAGCGTCATTGAAGCACAAA
AACGCATTGAACCACGTCAAAACAAGGTTAAGCCATACCTGCCAATGGAAGGTTTTAAACCTTACCGTGATGCAATTCAA
ACCTTGCTCTTTGGTCACAATAGCCCAGCAGTTAAAGCAGGGCGTGCCGTGACCATTCAGACGCTTGGTGGCTCAGGTGC
ACTTAAAGTGGGTGCAGATTTTTTAAAAAACTATTTCCCAGATTCAGAAGTCTGGGTAAGCCAGCCAACCTGGGATAATC
ATATCGCCATTTTTAATGGTGCAGGATTTAAAACGCATTTTTATCCGTACTTTGATGCAGAAACACGTGGTCTCGATTTT
GAAGGCATGTTAGCGACATTAAAACAGCTTCCAAAGCACAGCATTGTGCTACTACATCCATGCTGTCATAACCCGACTGG
TGTTGATCTGGTACCGGCACAATGGGATCAGGTCATTGACGTATTAAAAGCAGGCCATCTGATTCCTTTCCTCGACATTG
CCTATCAGGGCTTTGGTGATGGCATGGAGCAAGATGCTTATGCAATTCGTGCACTTGATCAGTCTGGTCTTAATTTTATT
GTCAGCAATTCGTTCTCCAAAATCTTTTCACTGTATGGCGAACGTGTAGGCGGGCTCACCTTTGTTTGTGATGATGCCGA
AGCAGCTCAATGCACTTTTGGCCAGTTAAAAGCGACTGTACGTCGAATTTATTCTAGTCCACCGACTACAGGTGCATGGT
TGGTCGATCAGGTCTTGAATGATGCTGAACTCAGTCAACAGTGGCAAAATGAAGTTAAGGAGATGCGTGAACGTATTCTC
AAAATGCGTATCATTTTACGTGATGAATTGACCAAGGCTTTACCAGATCGTGACTTTAACTATCTGGTCGATCAAAAAGG
CATGTTTAGCTATACAGGTTTGACTGCAGATCAGGTCGATACCCTGCGTGAAGATTATGCCATCTATCTGGTTCGTAGTG
GCCGTATTTGTGTTGCGGGTTTAAACATGAATAATGTCTATATTGTAGCCAAAGCGATGGCTGAAGTATTAGCCACCGAA
GTGACTCCTGCTTAA

Upstream 100 bases:

>100_bases
GTTACATTAATTGAGTTTAAGGCTCTTGAGCACCTTAAACTCACCTACTTCACTACGACACAGTTAGTGGTTCCAACTGT
GGAATGCAAGGATTTTTTTG

Downstream 100 bases:

>100_bases
GATTATCCTACACAACGCCAGTTGTACTTTAGAAATTTTACAAAGTCATAACTGGCTTCTTTCAATATTGTCTTTTTTGT
TACAGAGCCTCACTATTTTT

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MFQHIPPYAGDPILSLMEQFNADSREAKVNLSIGLYYNEDSIVPQLDSVIEAQKRIEPRQNKVKPYLPMEGFKPYRDAIQ
TLLFGHNSPAVKAGRAVTIQTLGGSGALKVGADFLKNYFPDSEVWVSQPTWDNHIAIFNGAGFKTHFYPYFDAETRGLDF
EGMLATLKQLPKHSIVLLHPCCHNPTGVDLVPAQWDQVIDVLKAGHLIPFLDIAYQGFGDGMEQDAYAIRALDQSGLNFI
VSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDQVLNDAELSQQWQNEVKEMRERIL
KMRIILRDELTKALPDRDFNYLVDQKGMFSYTGLTADQVDTLREDYAIYLVRSGRICVAGLNMNNVYIVAKAMAEVLATE
VTPA

Sequences:

>Translated_404_residues
MFQHIPPYAGDPILSLMEQFNADSREAKVNLSIGLYYNEDSIVPQLDSVIEAQKRIEPRQNKVKPYLPMEGFKPYRDAIQ
TLLFGHNSPAVKAGRAVTIQTLGGSGALKVGADFLKNYFPDSEVWVSQPTWDNHIAIFNGAGFKTHFYPYFDAETRGLDF
EGMLATLKQLPKHSIVLLHPCCHNPTGVDLVPAQWDQVIDVLKAGHLIPFLDIAYQGFGDGMEQDAYAIRALDQSGLNFI
VSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDQVLNDAELSQQWQNEVKEMRERIL
KMRIILRDELTKALPDRDFNYLVDQKGMFSYTGLTADQVDTLREDYAIYLVRSGRICVAGLNMNNVYIVAKAMAEVLATE
VTPA
>Mature_404_residues
MFQHIPPYAGDPILSLMEQFNADSREAKVNLSIGLYYNEDSIVPQLDSVIEAQKRIEPRQNKVKPYLPMEGFKPYRDAIQ
TLLFGHNSPAVKAGRAVTIQTLGGSGALKVGADFLKNYFPDSEVWVSQPTWDNHIAIFNGAGFKTHFYPYFDAETRGLDF
EGMLATLKQLPKHSIVLLHPCCHNPTGVDLVPAQWDQVIDVLKAGHLIPFLDIAYQGFGDGMEQDAYAIRALDQSGLNFI
VSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDQVLNDAELSQQWQNEVKEMRERIL
KMRIILRDELTKALPDRDFNYLVDQKGMFSYTGLTADQVDTLREDYAIYLVRSGRICVAGLNMNNVYIVAKAMAEVLATE
VTPA

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=41.2060301507538, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI4504067, Length=404, Percent_Identity=41.5841584158416, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI117414139, Length=338, Percent_Identity=28.9940828402367, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1790488, Length=397, Percent_Identity=64.2317380352645, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1787159, Length=397, Percent_Identity=41.0579345088161, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=37.1212121212121, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI25147133, Length=396, Percent_Identity=38.8888888888889, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17569539, Length=398, Percent_Identity=38.1909547738693, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17569537, Length=400, Percent_Identity=32.5, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17550384, Length=268, Percent_Identity=35.8208955223881, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=36.7924528301887, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323055, Length=406, Percent_Identity=38.9162561576355, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322743, Length=429, Percent_Identity=33.5664335664336, Blast_Score=216, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24580970, Length=396, Percent_Identity=38.8888888888889, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI19920542, Length=393, Percent_Identity=38.9312977099237, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24580972, Length=393, Percent_Identity=38.9312977099237, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=39.2405063291139, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=39.2405063291139, Blast_Score=295, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 45193; Mature: 45193

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQHIPPYAGDPILSLMEQFNADSREAKVNLSIGLYYNEDSIVPQLDSVIEAQKRIEPRQ
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHH
NKVKPYLPMEGFKPYRDAIQTLLFGHNSPAVKAGRAVTIQTLGGSGALKVGADFLKNYFP
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
DSEVWVSQPTWDNHIAIFNGAGFKTHFYPYFDAETRGLDFEGMLATLKQLPKHSIVLLHP
CCCEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGVDLVPAQWDQVIDVLKAGHLIPFLDIAYQGFGDGMEQDAYAIRALDQSGLNFI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEE
VSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDQVLN
EECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DAELSQQWQNEVKEMRERILKMRIILRDELTKALPDRDFNYLVDQKGMFSYTGLTADQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEECCCCHHHHH
TLREDYAIYLVRSGRICVAGLNMNNVYIVAKAMAEVLATEVTPA
HHHCCEEEEEEECCCEEEEECCCCCEEEHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQHIPPYAGDPILSLMEQFNADSREAKVNLSIGLYYNEDSIVPQLDSVIEAQKRIEPRQ
CCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCHH
NKVKPYLPMEGFKPYRDAIQTLLFGHNSPAVKAGRAVTIQTLGGSGALKVGADFLKNYFP
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCC
DSEVWVSQPTWDNHIAIFNGAGFKTHFYPYFDAETRGLDFEGMLATLKQLPKHSIVLLHP
CCCEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEC
CCHNPTGVDLVPAQWDQVIDVLKAGHLIPFLDIAYQGFGDGMEQDAYAIRALDQSGLNFI
CCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEE
VSNSFSKIFSLYGERVGGLTFVCDDAEAAQCTFGQLKATVRRIYSSPPTTGAWLVDQVLN
EECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DAELSQQWQNEVKEMRERILKMRIILRDELTKALPDRDFNYLVDQKGMFSYTGLTADQVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEECCCCHHHHH
TLREDYAIYLVRSGRICVAGLNMNNVYIVAKAMAEVLATEVTPA
HHHCCEEEEEEECCCEEEEECCCCCEEEHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]