Click here to switch to the map view.

The map label for this gene is vipA [H]

Identifier: 50083378

GI number: 50083378

Start: 82926

End: 84218

Strand: Direct

Name: vipA [H]

Synonym: ACIAD0087

Alternate gene names: 50083378

Gene position: 82926-84218 (Clockwise)

Preceding gene: 50083376

Following gene: 50083379

Centisome position: 2.3

GC content: 44.93

Gene sequence:

>1293_bases
ATGTCTTGTCGCATGCCTCTGGATCTACAAAATCTTCGTATTGCTATCATTGGTTTAGGTTATGTGGGCTTACCGCTGGC
CGTAGAGTTTGGCAAGCATGTATCTGTTGTGGGTTTTGATATCCATCAAAAGCGTGTGGCAGAGCTACAGCAGGGGCAAG
ATCATACCCTTGAAGTGACTCCCGAAGAACTCAAGCAGGCACAGTTGTTAAGTTATTCTTGTGATCTATCGGACTTGAAA
GACTGTAATTTCTTTATTGTGACCGTACCTACCCCAATCGATCAGTTTAAACAGCCTGACTTGACCCCACTAATCAAGGC
TTCACAAAGCATTGGCAAGGTGCTCAAAAAAGACGATATCGTGGTGTATGAGTCGACGGTATATCCGGGTGCCACCGAAG
AAGTCTGTGTCCCTGTACTGGAACAGGTGTCAGGTCTAACTTTCAATCAGGATTTTTTTACAGGCTATAGTCCAGAGCGT
ATTAATCCAGGCGATAAAGCCCACCGCGTGACCAATATTTTAAAAATCACGGCAGGTTCTACACCAGAAGTTGCAGATTA
TGTCGATGCAGTGTACCAATTGATTATTGAAGTGGGTACGCATAAGGCGCCAAGTATTAAAGTCGCAGAAGCAGCAAAGG
TGATTGAAAACACCCAGCGTGATGTCAATATTGCCTTAATCAATGAGCTTGCCATTATTTTTAATAAGATGGGTATCGAT
ACGCAGGATGTGCTTGAAGCCGCAGGAACCAAATGGAATTTCTTGCCGTTTCGCCCAGGTTTGGTGGGTGGACACTGCAT
TGGGGTTGACCCGTATTACCTGACGCATAAGGCTCAGGCGATTGGCTATCATCCAGAGATTATACTGGCAGGGCGTCGTC
TAAACGACAACATGAGTATGTACGTGGCCAATCAGCTCATCAAGAGCATGAACAAAAAGCGCATCCAGATTGAAGATGCC
AAAGTGCTGATTTTAGGCTTAACTTTTAAAGAAAACTGCCCCGATATTCGTAATACCAAAATTGTCGATATTATTAGCGA
GCTTAAAGATTTTAACATGCAGGTCGATGTTTATGACCCATGGGCAGATGCAGAAGAAACGCGTCATGAATATGCGATTG
ATCTGATTGCCGAGCCAGCGCAGGGCAGTTACGATGCCATCATTTTAGCGGTGGCACATCAGCAGTTTAAAGCAATGGGT
GCAGCCGCCATACATGCGCTGGGACGCAGTAACCATGTGATTTATGATCTGAAATATGTGCTGGATCGTCAGCAGTCAGA
TATTCGTCTGTAA

Upstream 100 bases:

>100_bases
AAATCTGGTTTATGATTAAATTTCATGGAAAAAAATGACACATTTCAGTGTTGAGAATGTTGTAGAATAACGTTATCTAT
TCACAGAATAATCAACGTTT

Downstream 100 bases:

>100_bases
GTCGCACACTCAGGATGGATGATATGGTCATGACAGCTTATCAAAAACAATGTATCACATTGCAGGCCGCACCCAAGACT
TGGTTGATTACAGGCGTTGC

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSCRMPLDLQNLRIAIIGLGYVGLPLAVEFGKHVSVVGFDIHQKRVAELQQGQDHTLEVTPEELKQAQLLSYSCDLSDLK
DCNFFIVTVPTPIDQFKQPDLTPLIKASQSIGKVLKKDDIVVYESTVYPGATEEVCVPVLEQVSGLTFNQDFFTGYSPER
INPGDKAHRVTNILKITAGSTPEVADYVDAVYQLIIEVGTHKAPSIKVAEAAKVIENTQRDVNIALINELAIIFNKMGID
TQDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDNMSMYVANQLIKSMNKKRIQIEDA
KVLILGLTFKENCPDIRNTKIVDIISELKDFNMQVDVYDPWADAEETRHEYAIDLIAEPAQGSYDAIILAVAHQQFKAMG
AAAIHALGRSNHVIYDLKYVLDRQQSDIRL

Sequences:

>Translated_430_residues
MSCRMPLDLQNLRIAIIGLGYVGLPLAVEFGKHVSVVGFDIHQKRVAELQQGQDHTLEVTPEELKQAQLLSYSCDLSDLK
DCNFFIVTVPTPIDQFKQPDLTPLIKASQSIGKVLKKDDIVVYESTVYPGATEEVCVPVLEQVSGLTFNQDFFTGYSPER
INPGDKAHRVTNILKITAGSTPEVADYVDAVYQLIIEVGTHKAPSIKVAEAAKVIENTQRDVNIALINELAIIFNKMGID
TQDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDNMSMYVANQLIKSMNKKRIQIEDA
KVLILGLTFKENCPDIRNTKIVDIISELKDFNMQVDVYDPWADAEETRHEYAIDLIAEPAQGSYDAIILAVAHQQFKAMG
AAAIHALGRSNHVIYDLKYVLDRQQSDIRL
>Mature_429_residues
SCRMPLDLQNLRIAIIGLGYVGLPLAVEFGKHVSVVGFDIHQKRVAELQQGQDHTLEVTPEELKQAQLLSYSCDLSDLKD
CNFFIVTVPTPIDQFKQPDLTPLIKASQSIGKVLKKDDIVVYESTVYPGATEEVCVPVLEQVSGLTFNQDFFTGYSPERI
NPGDKAHRVTNILKITAGSTPEVADYVDAVYQLIIEVGTHKAPSIKVAEAAKVIENTQRDVNIALINELAIIFNKMGIDT
QDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDNMSMYVANQLIKSMNKKRIQIEDAK
VLILGLTFKENCPDIRNTKIVDIISELKDFNMQVDVYDPWADAEETRHEYAIDLIAEPAQGSYDAIILAVAHQQFKAMGA
AAIHALGRSNHVIYDLKYVLDRQQSDIRL

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=419, Percent_Identity=28.6396181384248, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17560350, Length=454, Percent_Identity=21.8061674008811, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17136908, Length=380, Percent_Identity=21.8421052631579, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47873; Mature: 47741

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCRMPLDLQNLRIAIIGLGYVGLPLAVEFGKHVSVVGFDIHQKRVAELQQGQDHTLEVT
CCCCCCCCCCCCEEEEEEECHHCCHHHEECCCEEEEEEECHHHHHHHHHHCCCCCEEEEC
PEELKQAQLLSYSCDLSDLKDCNFFIVTVPTPIDQFKQPDLTPLIKASQSIGKVLKKDDI
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCE
VVYESTVYPGATEEVCVPVLEQVSGLTFNQDFFTGYSPERINPGDKAHRVTNILKITAGS
EEEECCCCCCCCHHHHHHHHHHHCCCEECCHHCCCCCCCCCCCCHHHHHHHHEEEEECCC
TPEVADYVDAVYQLIIEVGTHKAPSIKVAEAAKVIENTQRDVNIALINELAIIFNKMGID
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCC
TQDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDNMSM
HHHHHHHCCCCCCEECCCCCCCCCEEECCCCEEEEECHHHCCCCCEEEEECCEECCCHHH
YVANQLIKSMNKKRIQIEDAKVLILGLTFKENCPDIRNTKIVDIISELKDFNMQVDVYDP
HHHHHHHHHCCCCEEEEECCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECC
WADAEETRHEYAIDLIAEPAQGSYDAIILAVAHQQFKAMGAAAIHALGRSNHVIYDLKYV
CCCHHHHHHHEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
LDRQQSDIRL
HCCCCCCCCC
>Mature Secondary Structure 
SCRMPLDLQNLRIAIIGLGYVGLPLAVEFGKHVSVVGFDIHQKRVAELQQGQDHTLEVT
CCCCCCCCCCCEEEEEEECHHCCHHHEECCCEEEEEEECHHHHHHHHHHCCCCCEEEEC
PEELKQAQLLSYSCDLSDLKDCNFFIVTVPTPIDQFKQPDLTPLIKASQSIGKVLKKDDI
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCE
VVYESTVYPGATEEVCVPVLEQVSGLTFNQDFFTGYSPERINPGDKAHRVTNILKITAGS
EEEECCCCCCCCHHHHHHHHHHHCCCEECCHHCCCCCCCCCCCCHHHHHHHHEEEEECCC
TPEVADYVDAVYQLIIEVGTHKAPSIKVAEAAKVIENTQRDVNIALINELAIIFNKMGID
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCC
TQDVLEAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRLNDNMSM
HHHHHHHCCCCCCEECCCCCCCCCEEECCCCEEEEECHHHCCCCCEEEEECCEECCCHHH
YVANQLIKSMNKKRIQIEDAKVLILGLTFKENCPDIRNTKIVDIISELKDFNMQVDVYDP
HHHHHHHHHCCCCEEEEECCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEECC
WADAEETRHEYAIDLIAEPAQGSYDAIILAVAHQQFKAMGAAAIHALGRSNHVIYDLKYV
CCCHHHHHHHEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
LDRQQSDIRL
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]