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The map label for this gene is fklB [H]

Identifier: 50083359

GI number: 50083359

Start: 62660

End: 63358

Strand: Reverse

Name: fklB [H]

Synonym: ACIAD0065

Alternate gene names: 50083359

Gene position: 63358-62660 (Counterclockwise)

Preceding gene: 50083360

Following gene: 50083356

Centisome position: 1.76

GC content: 44.21

Gene sequence:

>699_bases
ATGATGAAAAAAATAGGTTTGGCTCTGATCGCCTCAAGTATGACAGTGACTGCTTTTGCCGCATCGATTGGTGCATCGAG
TCCACAAAAAGATCAACTGGGCTATAGCTATGGTTACGTTATGGGACGTACCAATGCAGATACATTAAAGGATCTGAATG
TAGATGCTTTTGTTCAGGGCCTTAAAGAAGGTGCTCAAGGCAAGGATTCAGCTTTGAGCGATGAGGCCATGGCTAAAGTT
CTAAGCCAGTATAAAAAGCAGGTCGAAGCCAAACAGCTCTATGCATTTCAGCAATTGGCACAAGATAACCTCAAACGTGG
TGAAGCTTTTCTTGCAGAAAATGCCAAGAAATCGGGTGTGATTAGCACTAAATCGGGTTTGCAGTATCAAGTACTCAGTG
CAGGGAAAGGTAAATCACCGAAAGCCAGTTCTCGCGTAAAAGTAAATTACGAGGGGCGTTTACTGGACGGTACAGTCTTT
GACAGCTCAATTGCCCGTAATCATCCTGTCGAGTTTCAGCTCAGCCAAGTGATTCCAGGCTGGACCGAAGGCTTGCAACT
GATGAAAGAAGGTGAAAAAGCGCGTCTGTTTATTCCAGCCAAACTTGCGTATGGTGAAGTCGGTAGCGGTGATGCGATTG
GACCAAATAGTACGCTGATTTTTGATATCGAATTACTGGAAATTCTTCCATCCAAATAA

Upstream 100 bases:

>100_bases
GATCCCACCAAACAGTACTTTAATTTTTGATGTAGAACTGTTAGAAGTGAAATAGTGAAAAAGGAGAGTGCGATACTCTC
CTTATTTTTTTGGAAATATC

Downstream 100 bases:

>100_bases
TAAAAAACGCTGTCATGATGACAGCGTTTTTTATTCATGCACGATATTGCGCTACTGCATAAATAAAGCGTTGCTTTTGT
TATCTACGCGCTTCGCTTGT

Product: FKBP-type 22KD peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MMKKIGLALIASSMTVTAFAASIGASSPQKDQLGYSYGYVMGRTNADTLKDLNVDAFVQGLKEGAQGKDSALSDEAMAKV
LSQYKKQVEAKQLYAFQQLAQDNLKRGEAFLAENAKKSGVISTKSGLQYQVLSAGKGKSPKASSRVKVNYEGRLLDGTVF
DSSIARNHPVEFQLSQVIPGWTEGLQLMKEGEKARLFIPAKLAYGEVGSGDAIGPNSTLIFDIELLEILPSK

Sequences:

>Translated_232_residues
MMKKIGLALIASSMTVTAFAASIGASSPQKDQLGYSYGYVMGRTNADTLKDLNVDAFVQGLKEGAQGKDSALSDEAMAKV
LSQYKKQVEAKQLYAFQQLAQDNLKRGEAFLAENAKKSGVISTKSGLQYQVLSAGKGKSPKASSRVKVNYEGRLLDGTVF
DSSIARNHPVEFQLSQVIPGWTEGLQLMKEGEKARLFIPAKLAYGEVGSGDAIGPNSTLIFDIELLEILPSK
>Mature_232_residues
MMKKIGLALIASSMTVTAFAASIGASSPQKDQLGYSYGYVMGRTNADTLKDLNVDAFVQGLKEGAQGKDSALSDEAMAKV
LSQYKKQVEAKQLYAFQQLAQDNLKRGEAFLAENAKKSGVISTKSGLQYQVLSAGKGKSPKASSRVKVNYEGRLLDGTVF
DSSIARNHPVEFQLSQVIPGWTEGLQLMKEGEKARLFIPAKLAYGEVGSGDAIGPNSTLIFDIELLEILPSK

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=43.3962264150943, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=43.3962264150943, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=49.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=49.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=49.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=40.5660377358491, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI192448443, Length=113, Percent_Identity=38.0530973451327, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI224809329, Length=101, Percent_Identity=42.5742574257426, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI224809327, Length=101, Percent_Identity=42.5742574257426, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4758384, Length=101, Percent_Identity=42.5742574257426, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4503729, Length=91, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503727, Length=109, Percent_Identity=43.1192660550459, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI224809331, Length=133, Percent_Identity=38.3458646616541, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI33469985, Length=85, Percent_Identity=43.5294117647059, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8923659, Length=96, Percent_Identity=43.75, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI87082390, Length=199, Percent_Identity=44.2211055276382, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1789745, Length=204, Percent_Identity=40.6862745098039, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17540882, Length=90, Percent_Identity=46.6666666666667, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=90, Percent_Identity=42.2222222222222, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=37.7358490566038, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=87, Percent_Identity=49.4252873563218, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=100, Percent_Identity=45, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24583150, Length=109, Percent_Identity=42.2018348623853, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=43.3962264150943, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=47.2527472527472, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=47.2527472527472, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356629, Length=93, Percent_Identity=48.3870967741936, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=41.9354838709677, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24932; Mature: 24932

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKIGLALIASSMTVTAFAASIGASSPQKDQLGYSYGYVMGRTNADTLKDLNVDAFVQG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCHHHHHCCHHHHHHH
LKEGAQGKDSALSDEAMAKVLSQYKKQVEAKQLYAFQQLAQDNLKRGEAFLAENAKKSGV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
ISTKSGLQYQVLSAGKGKSPKASSRVKVNYEGRLLDGTVFDSSIARNHPVEFQLSQVIPG
EECCCCCEEEEEECCCCCCCCCCCEEEEEECCEEEECCCCCCHHHCCCCCEEEHHHCCCC
WTEGLQLMKEGEKARLFIPAKLAYGEVGSGDAIGPNSTLIFDIELLEILPSK
HHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHCCCC
>Mature Secondary Structure
MMKKIGLALIASSMTVTAFAASIGASSPQKDQLGYSYGYVMGRTNADTLKDLNVDAFVQG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEECCCCHHHHHCCHHHHHHH
LKEGAQGKDSALSDEAMAKVLSQYKKQVEAKQLYAFQQLAQDNLKRGEAFLAENAKKSGV
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
ISTKSGLQYQVLSAGKGKSPKASSRVKVNYEGRLLDGTVFDSSIARNHPVEFQLSQVIPG
EECCCCCEEEEEECCCCCCCCCCCEEEEEECCEEEECCCCCCHHHCCCCCEEEHHHCCCC
WTEGLQLMKEGEKARLFIPAKLAYGEVGSGDAIGPNSTLIFDIELLEILPSK
HHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7516906 [H]