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The map label for this gene is gph2 [H]

Identifier: 50083337

GI number: 50083337

Start: 47833

End: 48540

Strand: Reverse

Name: gph2 [H]

Synonym: ACIAD0043

Alternate gene names: 50083337

Gene position: 48540-47833 (Counterclockwise)

Preceding gene: 50083338

Following gene: 50083336

Centisome position: 1.35

GC content: 46.61

Gene sequence:

>708_bases
ATGAAAGCAGTTTTATTTGACCTTGATGGAACCTTAATTGATACGGCTGCGGACTTTATTCGCATCATTCAAGAAATGTG
TCGTGAAGAACAGCGCGAAGTGGTTGATGCCGATCTGATTCGTACACAGGTATCCGAAGGTGCACGTGCGATGGTCAAGC
TGGTGTATCCTGAACTGGCTGTCGATGATGCGGTATTTCTGACGCATCGTCAGCGCTTTTTAGACAGATATGAACAGAAT
ATCGTGGTGGATACCGACCTGTTTAAAGGGATGTATCCTTTACTTGAAATGCTCGAATCCCAACAAATTCCTTGGGGCAT
TGTCACCAACAAACCACGTCATTTGACTGAGTTGCTACTAGAACGCCTGAACCTGACCGAGCGCTGTGCGGTGCTGGTCT
GCCCTGAAGATGTGCAAAGAACCAAACCAGACCCTGAACCGATGTTTCTGGCAGCAACCCAACTGCACATCGCACCTGAG
CAGATCATTTACGTCGGCGATCATCCAAGAGATATCGACGCCGGTCGTGCCGCACACATGTACACCATTTTGGCTGCTTA
CGGTTATTTACCCCTGCAACATAAAGACAACCTGAATGCATGGCAGGCTGACGTGATTGTTCAGCATGTTACCGAGTTAC
AGAAAATTTTGTCTCAACAGCTACACATTACGCCATTAAATCAGGATACTATGCTACAAACATCATAA

Upstream 100 bases:

>100_bases
ATATGACGGGTTTGCACTACAATCCATTGACCAAACACTATTGGCTGGCGCCAAATGTCGATGTCAATTACATGGTGCAT
ACCCTCAAAGAAGGTCAATC

Downstream 100 bases:

>100_bases
TAATGACTCGATTTTAAAGGAGGTTTTCCAATGAAATATTCAGAATATCAACCTCGTACCGACTTATTAAAAGGCCGTAT
TATTTTAATTACAGGTGCAG

Product: phosphoglycolate phosphatase 2 (PGP 2)

Products: NA

Alternate protein names: PGP 2; PGPase2 [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKAVLFDLDGTLIDTAADFIRIIQEMCREEQREVVDADLIRTQVSEGARAMVKLVYPELAVDDAVFLTHRQRFLDRYEQN
IVVDTDLFKGMYPLLEMLESQQIPWGIVTNKPRHLTELLLERLNLTERCAVLVCPEDVQRTKPDPEPMFLAATQLHIAPE
QIIYVGDHPRDIDAGRAAHMYTILAAYGYLPLQHKDNLNAWQADVIVQHVTELQKILSQQLHITPLNQDTMLQTS

Sequences:

>Translated_235_residues
MKAVLFDLDGTLIDTAADFIRIIQEMCREEQREVVDADLIRTQVSEGARAMVKLVYPELAVDDAVFLTHRQRFLDRYEQN
IVVDTDLFKGMYPLLEMLESQQIPWGIVTNKPRHLTELLLERLNLTERCAVLVCPEDVQRTKPDPEPMFLAATQLHIAPE
QIIYVGDHPRDIDAGRAAHMYTILAAYGYLPLQHKDNLNAWQADVIVQHVTELQKILSQQLHITPLNQDTMLQTS
>Mature_235_residues
MKAVLFDLDGTLIDTAADFIRIIQEMCREEQREVVDADLIRTQVSEGARAMVKLVYPELAVDDAVFLTHRQRFLDRYEQN
IVVDTDLFKGMYPLLEMLESQQIPWGIVTNKPRHLTELLLERLNLTERCAVLVCPEDVQRTKPDPEPMFLAATQLHIAPE
QIIYVGDHPRDIDAGRAAHMYTILAAYGYLPLQHKDNLNAWQADVIVQHVTELQKILSQQLHITPLNQDTMLQTS

Specific function: Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stres

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1789787, Length=237, Percent_Identity=30.379746835443, Blast_Score=107, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR006346
- InterPro:   IPR023198 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.1.3.18 [H]

Molecular weight: Translated: 26969; Mature: 26969

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVLFDLDGTLIDTAADFIRIIQEMCREEQREVVDADLIRTQVSEGARAMVKLVYPELA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDDAVFLTHRQRFLDRYEQNIVVDTDLFKGMYPLLEMLESQQIPWGIVTNKPRHLTELLL
HCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
ERLNLTERCAVLVCPEDVQRTKPDPEPMFLAATQLHIAPEQIIYVGDHPRDIDAGRAAHM
HHHCCHHHCEEEECCHHHHHCCCCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCHHHH
YTILAAYGYLPLQHKDNLNAWQADVIVQHVTELQKILSQQLHITPLNQDTMLQTS
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MKAVLFDLDGTLIDTAADFIRIIQEMCREEQREVVDADLIRTQVSEGARAMVKLVYPELA
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDDAVFLTHRQRFLDRYEQNIVVDTDLFKGMYPLLEMLESQQIPWGIVTNKPRHLTELLL
HCHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
ERLNLTERCAVLVCPEDVQRTKPDPEPMFLAATQLHIAPEQIIYVGDHPRDIDAGRAAHM
HHHCCHHHCEEEECCHHHHHCCCCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCHHHH
YTILAAYGYLPLQHKDNLNAWQADVIVQHVTELQKILSQQLHITPLNQDTMLQTS
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]