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The map label for this gene is hcaK [H]

Identifier: 161349966

GI number: 161349966

Start: 1736498

End: 1737730

Strand: Direct

Name: hcaK [H]

Synonym: ACIAD1727

Alternate gene names: 161349966

Gene position: 1736498-1737730 (Clockwise)

Preceding gene: 50084873

Following gene: 50084882

Centisome position: 48.25

GC content: 45.58

Gene sequence:

>1233_bases
ATGGATACCGTATCGAAGGCGTCGGGAAGGGCGAAACTTACGTTACTGCTGTGCTTTGCTATAGCGATATTTGAAGGCTT
TGATCTTCAATCGATGGGTGTAGCAGCACCGCGAATGCGTGCCGAATTTATGTTAGATAATGCCCAAATGGCTTGGGCAT
TTAGTGCTGCAATTATTGGAACCCTGCCAGGCGCGATTATCGGTGGTCGTTTGGCAGATATTGTAGGCCGTAAAAAGATT
TTAATTTTGAGTATTATGCTGTTCGGGATCATGTCATTACTGACAGCTTTTGCCGCTAACTATAACTTATTGCTGGTGAT
TCGTTTTCTTACTGGTTTAGGTATGGGCGGTGCATTACCCATGATGATTACGGTCGCATCAGAAGCTGTGGCTGAAAACC
GCAAGGCCACCGCAGTCAGTATTATGTACAGTGGCATTCCATTTGGAGGGCTACTGACCTCTGTTGTGGCTATGCTTATG
GCAGGCGATGCAGAGTGGCGGCATATTTTTTATGTGGGTGGTATTGCACCGATATTACTCATTCCACTCTTAATGAAGTT
CTTACCTGAATCCAACAGCTATCTGCAGAAAAAAACACACCTGCAAAGTACAACACCATTTTGGGAAGTGCTGTTTGCAA
AAGAAAGACGGATGTCGACCATTCAATTATGGATCAGTTTCTTTTGTACGCTGGTGGTGCTCTATTTCTTGCTGAACTGG
TTACCACTGCTTATGGGTTCACAAGGATTGTCTAAACTTGAAGCCAATTATGTACAGATGGGATACAACGTAGGCGGAAT
TTTTGGTTCTATTTTGATGGGTATGCTGCTCGACAAGATGCGTATGAGCAGTGTCATTAAGTTTATCTATGCGGGTATTC
TGGTCGCTTTGTGTTGTCTGTCGATTTCACCAACAGTTGCATTGCTGGCACTTTCTGCCGTGGGTTGTGGCTTGTTTATT
GTGGGTGGACAATCTGCTTTATATGGTCTGGCGGCAATGTATTATCCAACCGAAATGCGTGGCACGGGGGTGGGCGCAGC
AGTTGCAATTGGACGCATAGGTTCTTTTGCCGGGCCGTTGGTTGCAGGTTTCCTACTTTCGTTAGGTCAGAGCTCGACCA
TCGTCATTGGTTCAAGTATTCCGATTATCCTGATTGCTGCAATATCTGCACTAATGCTTGTCAGAAAGCCCAAACACCCT
GTACATTTGGCGCATGGCTCAAGCGCTCAGTAA

Upstream 100 bases:

>100_bases
ATATTGATTTTTTTATAAGCTTAACTGATATTTTATGTGTGTTCTTTGAACATTGACAATAAAAACGTAAAGGATGTTTA
GTCAAAATAAGGAAGAGACT

Downstream 100 bases:

>100_bases
CATTCTTTTAAAAGTATGGGGCTGATTGGCCTCATACTTTTTAATTTTTTATGAAGATAAATTATGCTACGTTCAAGTTC
AGTTGATAGAAAAAGAGAAG

Product: 3-hydroxyphenylpropionic transporter MhpT

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDTVSKASGRAKLTLLLCFAIAIFEGFDLQSMGVAAPRMRAEFMLDNAQMAWAFSAAIIGTLPGAIIGGRLADIVGRKKI
LILSIMLFGIMSLLTAFAANYNLLLVIRFLTGLGMGGALPMMITVASEAVAENRKATAVSIMYSGIPFGGLLTSVVAMLM
AGDAEWRHIFYVGGIAPILLIPLLMKFLPESNSYLQKKTHLQSTTPFWEVLFAKERRMSTIQLWISFFCTLVVLYFLLNW
LPLLMGSQGLSKLEANYVQMGYNVGGIFGSILMGMLLDKMRMSSVIKFIYAGILVALCCLSISPTVALLALSAVGCGLFI
VGGQSALYGLAAMYYPTEMRGTGVGAAVAIGRIGSFAGPLVAGFLLSLGQSSTIVIGSSIPIILIAAISALMLVRKPKHP
VHLAHGSSAQ

Sequences:

>Translated_410_residues
MDTVSKASGRAKLTLLLCFAIAIFEGFDLQSMGVAAPRMRAEFMLDNAQMAWAFSAAIIGTLPGAIIGGRLADIVGRKKI
LILSIMLFGIMSLLTAFAANYNLLLVIRFLTGLGMGGALPMMITVASEAVAENRKATAVSIMYSGIPFGGLLTSVVAMLM
AGDAEWRHIFYVGGIAPILLIPLLMKFLPESNSYLQKKTHLQSTTPFWEVLFAKERRMSTIQLWISFFCTLVVLYFLLNW
LPLLMGSQGLSKLEANYVQMGYNVGGIFGSILMGMLLDKMRMSSVIKFIYAGILVALCCLSISPTVALLALSAVGCGLFI
VGGQSALYGLAAMYYPTEMRGTGVGAAVAIGRIGSFAGPLVAGFLLSLGQSSTIVIGSSIPIILIAAISALMLVRKPKHP
VHLAHGSSAQ
>Mature_410_residues
MDTVSKASGRAKLTLLLCFAIAIFEGFDLQSMGVAAPRMRAEFMLDNAQMAWAFSAAIIGTLPGAIIGGRLADIVGRKKI
LILSIMLFGIMSLLTAFAANYNLLLVIRFLTGLGMGGALPMMITVASEAVAENRKATAVSIMYSGIPFGGLLTSVVAMLM
AGDAEWRHIFYVGGIAPILLIPLLMKFLPESNSYLQKKTHLQSTTPFWEVLFAKERRMSTIQLWISFFCTLVVLYFLLNW
LPLLMGSQGLSKLEANYVQMGYNVGGIFGSILMGMLLDKMRMSSVIKFIYAGILVALCCLSISPTVALLALSAVGCGLFI
VGGQSALYGLAAMYYPTEMRGTGVGAAVAIGRIGSFAGPLVAGFLLSLGQSSTIVIGSSIPIILIAAISALMLVRKPKHP
VHLAHGSSAQ

Specific function: Could be a transporter for 3-phenylpropionate (hydrocinnamic acid) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=427, Percent_Identity=24.824355971897, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI154350196, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI73695465, Length=171, Percent_Identity=25.7309941520468, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI213021148, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI87081723, Length=384, Percent_Identity=43.4895833333333, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082404, Length=384, Percent_Identity=25.5208333333333, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789152, Length=442, Percent_Identity=23.3031674208145, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082231, Length=199, Percent_Identity=27.1356783919598, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082320, Length=433, Percent_Identity=23.7875288683603, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1788074, Length=395, Percent_Identity=23.7974683544304, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786229, Length=388, Percent_Identity=24.2268041237113, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789515, Length=409, Percent_Identity=22.4938875305623, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=407, Percent_Identity=21.1302211302211, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640198, Length=192, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640196, Length=192, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640200, Length=192, Percent_Identity=27.0833333333333, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43682; Mature: 43682

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTVSKASGRAKLTLLLCFAIAIFEGFDLQSMGVAAPRMRAEFMLDNAQMAWAFSAAIIG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
TLPGAIIGGRLADIVGRKKILILSIMLFGIMSLLTAFAANYNLLLVIRFLTGLGMGGALP
HCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHH
MMITVASEAVAENRKATAVSIMYSGIPFGGLLTSVVAMLMAGDAEWRHIFYVGGIAPILL
HHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
IPLLMKFLPESNSYLQKKTHLQSTTPFWEVLFAKERRMSTIQLWISFFCTLVVLYFLLNW
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLLMGSQGLSKLEANYVQMGYNVGGIFGSILMGMLLDKMRMSSVIKFIYAGILVALCCL
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISPTVALLALSAVGCGLFIVGGQSALYGLAAMYYPTEMRGTGVGAAVAIGRIGSFAGPL
CCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VAGFLLSLGQSSTIVIGSSIPIILIAAISALMLVRKPKHPVHLAHGSSAQ
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCC
>Mature Secondary Structure
MDTVSKASGRAKLTLLLCFAIAIFEGFDLQSMGVAAPRMRAEFMLDNAQMAWAFSAAIIG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
TLPGAIIGGRLADIVGRKKILILSIMLFGIMSLLTAFAANYNLLLVIRFLTGLGMGGALP
HCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHH
MMITVASEAVAENRKATAVSIMYSGIPFGGLLTSVVAMLMAGDAEWRHIFYVGGIAPILL
HHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
IPLLMKFLPESNSYLQKKTHLQSTTPFWEVLFAKERRMSTIQLWISFFCTLVVLYFLLNW
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPLLMGSQGLSKLEANYVQMGYNVGGIFGSILMGMLLDKMRMSSVIKFIYAGILVALCCL
HHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SISPTVALLALSAVGCGLFIVGGQSALYGLAAMYYPTEMRGTGVGAAVAIGRIGSFAGPL
CCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
VAGFLLSLGQSSTIVIGSSIPIILIAAISALMLVRKPKHPVHLAHGSSAQ
HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]