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The map label for this gene is serS

Identifier: 161349959

GI number: 161349959

Start: 2864057

End: 2865328

Strand: Reverse

Name: serS

Synonym: ACIAD2935

Alternate gene names: 161349959

Gene position: 2865328-2864057 (Counterclockwise)

Preceding gene: 50085963

Following gene: 50085961

Centisome position: 79.62

GC content: 44.34

Gene sequence:

>1272_bases
ATGATCGACCCAAAATTACTCAGAAATAATATTGAAGCTGTAAATCTGGCTCTTGCAAAACGTGGCGTGCAATTAGACCC
TACCGAATGGGCATCCCTTGAAGTCCGTCGTAAAGAGCTTCAATCGAAAACTGAAAGTTTGCAGGCAGAGCGTAATGCGG
GTGCCAAGCAAGTGGGGCAGATCAAAAAAGCAGGTGGTGATGCTTCAGAGATTATGACGCGTATGCAGGCGATTGGCGAT
GAAATCAAAGCTGCTGAAGTTGCACTGGCTGAATTACAAGCTGAAATCGAGCAAAAAGCGTTAAGCATTCCAAACTTGCC
TGATGAGTCTGTGCCAGAAGGCAAAGATGAAAATGATAATGTGGAAATTTCAAAATGGGGAACACCACGCCAGTTTGATT
TTGAAATCAAAGATCACACCGATTTAGGTGAGTGGATGGGTGGTCTTGAATTTGAGACCGCAACCAAATTAACAGGTTCA
CGTTTTAGCGTACTCAAAGGGCCATTAGCGCGGCTGCAACGTGCGCTGACTCAATTTATGCTAGATACGCATACTTTGAA
AAATGGTTATACCGAAGCCTATGTCCCTTATTTGGTCAATGCCGACTCATTACGGGGCACAGGTCAGTTACCTAAGTTTG
AAGAAGACTTATTCAAGCTACAAGGTGAAAAAGAATATTATTTGATTCCGACGGCTGAAGTTCCTGTCACTAATTTTGTG
CGTGATGAAATTATTGATGCAGAACGTCTGCCACTTAAGTATGCCGCACATACGCCTTGTTTCCGTAGCGAAGCAGGTTC
TTATGGACGTGATACACGTGGTCTGATTCGTCAGCATCAGTTTGATAAAGTTGAAATGGTGCAGATCGTTAAACCTGAAG
ATTCTATGCAGGCGCTTGAAGAGCTGACAGGACATGCGGAAGGTATTCTGCAGGCACTGGGATTGCCGTATCGCAAAATT
CTACTTTGTGGCGGTGATATGGGCTTTGGTTCAACCAAAACCTATGATCTTGAAGTATGGGTTCCAAGCCAGAATACTTA
TCGTGAAATTTCATCTTGTTCAAACATGGGTGACTTTCAGGCACGTCGCATGATGGCACGTTATCGTACCGATCAGAAGA
AAACTGAGCTGGTACATACTTTAAATGGTTCTGGTTTGGCTGTTGGGCGTACCTTGCTTGCCGTGATGGAAAATTATCAA
CGTGCTGATGGCGCGATTGAAGTGCCAGAAGTATTACGCCCGTACATGGGTGGTGCAACGTATATCGATTAA

Upstream 100 bases:

>100_bases
GATATCCAATTTAAAAATATAGTCACTCAAGGGTGACTATATTTTTTGGCGTGAAGCACTTACACTATAGGCAGTTTTTC
TCTTCAACTCATGATTGGCT

Downstream 100 bases:

>100_bases
TTGCATCGATTGTGTGCATGATTTTTGCTTTAACCCACCCAACGTTTTGATCTAGAGGTAGGCTGTGGAAATTTTTCCAA
TTTCTCTTAAGTTGCAGCAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQIKKAGGDASEIMTRMQAIGD
EIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALEELTGHAEGILQALGLPYRKI
LLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
RADGAIEVPEVLRPYMGGATYID

Sequences:

>Translated_423_residues
MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQIKKAGGDASEIMTRMQAIGD
EIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALEELTGHAEGILQALGLPYRKI
LLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
RADGAIEVPEVLRPYMGGATYID
>Mature_423_residues
MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQIKKAGGDASEIMTRMQAIGD
EIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGS
RFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
RDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALEELTGHAEGILQALGLPYRKI
LLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQ
RADGAIEVPEVLRPYMGGATYID

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=372, Percent_Identity=36.8279569892473, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI8923421, Length=394, Percent_Identity=30.2030456852792, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=30.9309309309309, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=67.5990675990676, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17539260, Length=365, Percent_Identity=34.2465753424658, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=363, Percent_Identity=30.0275482093664, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=29.6803652968037, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321799, Length=394, Percent_Identity=31.7258883248731, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=31.4655172413793, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17737985, Length=342, Percent_Identity=32.1637426900585, Blast_Score=152, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ACIAD (Q6F8G5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047472.2
- ProteinModelPortal:   Q6F8G5
- SMR:   Q6F8G5
- STRING:   Q6F8G5
- GeneID:   2879294
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2935
- NMPDR:   fig|62977.3.peg.2665
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q6F8G5
- ProtClustDB:   PRK05431
- BioCyc:   ASP62977:ACIAD2935-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47312; Mature: 47312

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQ
CCCHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKKAGGDASEIMTRMQAIGDEIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFM
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
RDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALE
HHHHCCHHCCCEEHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ELTGHAEGILQALGLPYRKILLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQ
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCHHH
ARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQRADGAIEVPEVLRPYMGGAT
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCCC
YID
CCC
>Mature Secondary Structure
MIDPKLLRNNIEAVNLALAKRGVQLDPTEWASLEVRRKELQSKTESLQAERNAGAKQVGQ
CCCHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IKKAGGDASEIMTRMQAIGDEIKAAEVALAELQAEIEQKALSIPNLPDESVPEGKDENDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFM
EEEEECCCCCEEEEEECCCCCHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFV
HHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHH
RDEIIDAERLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPEDSMQALE
HHHHCCHHCCCEEHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHH
ELTGHAEGILQALGLPYRKILLCGGDMGFGSTKTYDLEVWVPSQNTYREISSCSNMGDFQ
HHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCHHH
ARRMMARYRTDQKKTELVHTLNGSGLAVGRTLLAVMENYQRADGAIEVPEVLRPYMGGAT
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEECHHHHHHHCCCCC
YID
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA