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The map label for this gene is vanSB [H]

Identifier: 49481372

GI number: 49481372

Start: 4591343

End: 4593196

Strand: Reverse

Name: vanSB [H]

Synonym: BT9727_4545

Alternate gene names: 49481372

Gene position: 4593196-4591343 (Counterclockwise)

Preceding gene: 49481373

Following gene: 49478769

Centisome position: 87.7

GC content: 31.77

Gene sequence:

>1854_bases
ATGAAAAAAGGGATTGTACTAAAGTTATTTACCCTCACAACAGCGCTATGTATGTTAATTTTAGCGACGATTTTTATTGG
ACAAACGATATTTTTTAAACAATATTATGCGAATCGAAAAGTAGAAGATATTAAAGTAAATTTAAATTCCTTTGAGAAGA
ATTATTTAAACAATGCAGGAAATACAGAAGAAATTAAGCGACTGGAGCAAGACTTTTTAAGAGAAAATAATACGTGGATT
ACGACATTAGATCAGAACGGGAATTTAAAGCATGCGGATGATTTTTATTTTGAGGTTACGATAGATCGCAAGCAACAGAA
GAGTTTTGGACAACAAATATTCAGAATTCCTTTATATAATCTCATCAATATAGAAGAGATTGATAATAAATCATCAAATC
CGTTTTTAGGCCAAGAAATTTATTTTTCTGGAGTGAAAAAAGAAGAAAGTTTTATTCCATTCTCTTTTTCGTTAGGTAAG
CAAAATTTGAATGGATCTAATAAACCGTTAGAAAAAGCATTTAATGAGAAAATGAGTAAATTAGATCAGGAGAAAAAGAA
AGCAGCTGAGGAACAATTCGGTAAGGAAAAGAAGCCGGTAGTTCAGGAGCAAGCTGCCCAAGAACCAGATGTTCACATAA
GAGGGCGTGTTACGAAAGTTCAGCTTCCGGATGTAACAGGTCCTATAAATCAAATTTATAAAAATAGCATCTTTTTAGAT
AACATAAAAGAATTTCAAACGGATTTATTATTAAAAGAGAGCAAGCCTATACAATCTACTACACAAACAATGGACTATGA
AAAAAATGATATAAAATATAAATTATTAATGAAACCGATAAAAGAAAAAGATGGATCGATAACATATATTTATGCAATGG
CTTCTTTACAGCCTGTAGATGAAGCTGTACAAATGGTGCAAGATTACTACATTTACATCATTGCATTTGTAGTCGTTCTT
ATTTTTCTCGCTGCATTTTATTATTCAAAACAAATTGCAAAACCGTTATTAAAAATAAATGATACGACGAAGAAAATAGC
GCATTTAGATTTCACAGAACAAATACCGATTACTTCAAAAGATGAAATTGGTGATTTATCGAAAAATATTAATACACTCT
CTAACAAATTAAATTCCCATATTGGACAGCTAGAACAAGATATTGAAAAGGAAAGAAAGTTAGAAAAGACGCGGAAAGAA
TTCATTTCTGGTGTTTCGCATGAACTAAAAACACCGCTGAGTATTATGAAAAGCTGTATTTTTATTTTAAAAGATGGAGT
AGCTGAGCATAAAAAAGATTACTATTTTCAAGCGATGGAACGGGAAGTAGACAAAATGGATACGTTAATTTTGGATATGC
TGGAGTTAGCTAAATTTGAGTCAGGCACATATAAAATGAAAAAGGACCCATTTTATATTGATACAGTAATTGAAGATATA
TGTGAACACCTTTCTGTAGAAATAGAGAAAAAAGAACTTCGTGTTCATAAACATATAGGTCCATTTGAAGTAGTCGCAAA
TCAAGGCCGGATTGAACAAGTCATCGTGAACTTCATTACGAATGCGATACGTTATACACCAAATAAAGAAGATATTATTA
TTTCTACAATAAATGAGAAGGATCGTATAAAAGTGTGTATTGAAAATAAAGGTACTCACATTGAAGAAGAGCAATTAGAT
AAAATTTGGGATCGTTTTTATCGCGTGGATGCAGCTCGCCAGCGTTCGCAAGGAGGAACAGGTCTTGGGCTTGCTATTTC
AAAGAACATTTTAGAACTCCATGATGCTGAATATGGGGTAGAAAATACAGAAGAGGGTGTATTATTTTATTTCTATTTAC
CAAAAAAAGCGTAG

Upstream 100 bases:

>100_bases
CAGTTAATAGTCATATTCGTAATTTAAGAAATAAATTAGGAGAGAAAGCAAAGTACATTACAACTGTAGTACGAACGGGT
TATAAATTTGAGGGGAATGT

Downstream 100 bases:

>100_bases
ACAATACAATCTACGCTTTTTTTAATTTTTTTCATATTATCTTTACCTAATCTTTATTTTTAATCAGTATAATTTGTTTA
GAAAATGAGGTTATGTAAGG

Product: sensor histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNNAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKPIQSTTQTMDYEKNDIKYKLLMKPIKEKDGSITYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCIFILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTINEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGVENTEEGVLFYFYLPKKA

Sequences:

>Translated_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNNAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKPIQSTTQTMDYEKNDIKYKLLMKPIKEKDGSITYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCIFILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTINEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGVENTEEGVLFYFYLPKKA
>Mature_617_residues
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNNAGNTEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYNLINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGSNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
NIKEFQTDLLLKESKPIQSTTQTMDYEKNDIKYKLLMKPIKEKDGSITYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCIFILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTINEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGVENTEEGVLFYFYLPKKA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=26.3940520446097, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.3898305084746, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786783, Length=327, Percent_Identity=24.7706422018349, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=28.2786885245902, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=340, Percent_Identity=23.8235294117647, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=335, Percent_Identity=22.089552238806, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=26.8722466960352, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=202, Percent_Identity=24.7524752475248, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=232, Percent_Identity=24.5689655172414, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=25.1101321585903, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=26.6949152542373, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=362, Percent_Identity=24.585635359116, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=24.3243243243243, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=23.4567901234568, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=280, Percent_Identity=23.5714285714286, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=20.3174603174603, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=25.1101321585903, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787374, Length=303, Percent_Identity=21.7821782178218, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71528; Mature: 71528

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNNAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
HCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCHHHH
NIKEFQTDLLLKESKPIQSTTQTMDYEKNDIKYKLLMKPIKEKDGSITYIYAMASLQPVD
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTINEK
HHHHCCEEHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGV
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEEGVLFYFYLPKKA
CCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNNAG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHCCCC
NTEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRKQQKSFGQQIFRIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
LINIEEIDNKSSNPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGSNKPLEKAFNEKMSK
HCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKKPVVQEQAAQEPDVHIRGRVTKVQLPDVTGPINQIYKNSIFLD
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCHHHH
NIKEFQTDLLLKESKPIQSTTQTMDYEKNDIKYKLLMKPIKEKDGSITYIYAMASLQPVD
HHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLAAFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINTLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FILKDGVAEHKKDYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDPFYIDTVIEDI
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTINEK
HHHHCCEEHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGV
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEEGVLFYFYLPKKA
CCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]