Click here to switch to the map view.

The map label for this gene is galE

Identifier: 49481245

GI number: 49481245

Start: 4998691

End: 4999683

Strand: Reverse

Name: galE

Synonym: BT9727_4945

Alternate gene names: 49481245

Gene position: 4999683-4998691 (Counterclockwise)

Preceding gene: 49478935

Following gene: 49480400

Centisome position: 95.46

GC content: 39.17

Gene sequence:

>993_bases
ATGAATTCAATTCTAATCTGCGGCGGAGCTGGTTATATCGGTTCTCACGCTGTGAAAAAATTAGTAGACGAAGGTTTATC
TGTAGTAGTAGTAGATAACTTACAAACTGGTCATGAGGATGCAATTACGGAAGGTGCGAAGTTTTATAATGGCGACCTTC
GTGATAAAGCATTTTTAAGAGATGTTTTTACAAAAGAAAATATTGAGGCGGTTATGCATTTCGCAGCTGATTCTTTAGTT
GGAGTTAGTATGGAGAAGCCTCTACAATATTATAATAATAACGTGTATGGTGCACTTTGCTTATTAGAGGTAATGGATGA
GTTTAAGGTAGATAAGTTTATTTTCTCTTCTACTGCGGCAACGTATGGTGAGGTAGATGTAGACCTTATTACTGAGGAAA
CGATGACAAATCCAACGAATACGTATGGAGAGACGAAGTTAGCAATCGAGAAGATGCTTCATTGGTATAGCCAAGCTTCT
AATTTACGTTATAAGATTTTCAGATACTTTAACGTGGCTGGTGCAACTCCAAATGGTATTATTGGGGAAGATCACCGTCC
AGAGACGCATTTAATTCCTCTTGTGTTGCAAGTGGCGTTAGGTCAACGTGAGAAGATTATGATGTTTGGTGATGACTATA
ATACACCAGATGGTACTTGTATCCGTGATTATATTCATGTTGAAGATTTAGTAGCGGCTCACTTCTTAGGTCTTAAGGAC
CTACAGAACGGCGGAGAAAGTGATTTCTATAACTTAGGAAATGGTAATGGTTTCAGCGTAAAAGAAATCGTTGATGCAGT
TCGTGAAGTTACAAATCATGAAATTCCAGCTGAGGTAGCGCCGCGTCGTGCAGGAGATCCAGCACGTTTAGTTGCTTCTT
CTCAGAAAGCGAAAGAGAAGTTAGGTTGGGATCCTCAGTATGTAAATGTGAAGACAATCATTGAGCATGCTTGGAATTGG
CATCAGAAGAAACCTAATGGGTATGAGAAATAA

Upstream 100 bases:

>100_bases
TTGCGAAGTAATAAAGGTACACAAAAGGTATACGAGCAATCGTATACCTTTTATAATAAGAGAGTGAATAAGAAATCCTA
ATATATGTAGGAGGAAGACA

Downstream 100 bases:

>100_bases
AATATAATAAGTGAAAGAGGGGTATTGTCGTTCAATATATGTTCGACAATACCCTCTCTTTTTTTATAAGATTTTTGCTA
TACTAAACTGTACTATAATA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLRDVFTKENIEAVMHFAADSLV
GVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAATYGEVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQAS
NLRYKIFRYFNVAGATPNGIIGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHFLGLKD
LQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQKAKEKLGWDPQYVNVKTIIEHAWNW
HQKKPNGYEK

Sequences:

>Translated_330_residues
MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLRDVFTKENIEAVMHFAADSLV
GVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAATYGEVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQAS
NLRYKIFRYFNVAGATPNGIIGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHFLGLKD
LQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQKAKEKLGWDPQYVNVKTIIEHAWNW
HQKKPNGYEK
>Mature_330_residues
MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLRDVFTKENIEAVMHFAADSLV
GVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAATYGEVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQAS
NLRYKIFRYFNVAGATPNGIIGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHFLGLKD
LQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQKAKEKLGWDPQYVNVKTIIEHAWNW
HQKKPNGYEK

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=341, Percent_Identity=37.8299120234604, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI56118217, Length=341, Percent_Identity=37.8299120234604, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI189083684, Length=341, Percent_Identity=37.8299120234604, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=27.9761904761905, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI42516563, Length=307, Percent_Identity=26.0586319218241, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1786974, Length=335, Percent_Identity=35.8208955223881, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI48994969, Length=337, Percent_Identity=29.3768545994065, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1788353, Length=337, Percent_Identity=27.299703264095, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790049, Length=276, Percent_Identity=30.0724637681159, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=36.8115942028986, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=36.5994236311239, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17539532, Length=313, Percent_Identity=24.6006389776358, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=26.4615384615385, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17568069, Length=324, Percent_Identity=26.5432098765432, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=40.9883720930233, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI19923002, Length=349, Percent_Identity=39.541547277937, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21356223, Length=310, Percent_Identity=24.5161290322581, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36886; Mature: 36886

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLR
CCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCHHCCCCCCHHHHHH
DVFTKENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TYGEVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQASNLRYKIFRYFNVAGATPNGI
CCCCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
IGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHFLGLKD
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQKAKEK
HCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHH
LGWDPQYVNVKTIIEHAWNWHQKKPNGYEK
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNSILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAITEGAKFYNGDLRDKAFLR
CCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCHHCCCCCCHHHHHH
DVFTKENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFSSTAA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TYGEVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQASNLRYKIFRYFNVAGATPNGI
CCCCCEEEEECHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
IGEDHRPETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAAHFLGLKD
CCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVASSQKAKEK
HCCCCCCCCEECCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHH
LGWDPQYVNVKTIIEHAWNWHQKKPNGYEK
CCCCCCEEHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]