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The map label for this gene is tipA

Identifier: 49481030

GI number: 49481030

Start: 4731710

End: 4732441

Strand: Reverse

Name: tipA

Synonym: BT9727_4678

Alternate gene names: 49481030

Gene position: 4732441-4731710 (Counterclockwise)

Preceding gene: 49480756

Following gene: 49480353

Centisome position: 90.35

GC content: 38.52

Gene sequence:

>732_bases
ATGGCAATGAAGGTAAAAGAAGTAGCTAATTTAGTTGGAATTAGTGTGCGCACACTGCATCATTATGATGAAATTGGGTT
GTTAATCCCAGACGAGACGACAGAGTCTGGATATCGTCTGTATTCCAATGAAAATTTAGAGACGTTGCAGCAAATTTTAT
TTTTTAAAGAACTAGGCTTCCCTTTGAAGAAAATTAAAGAAATTATCATGAGTCCATCATTTGACCGGAAAGAGGCATTA
CAGCTTCATAAGAAAATGCTTCTTGAAAAGCGTGCTAGGTTAGATAAAGTGATTGCGACGATTGATAAAACAATTCAGCA
TACAAAAGGAGAGATTGAAATGACGAACAAAGAGAAATTTGAAGGATTCGATTTCAGCCATAATCCGTACGAAGAAGAAG
CACGTGAAAGATGGGGAGACGCAGCTGTAGATAAAGCGAATGAATATGCGAAAGGTATGTCAAAAGAGAAGCAAGAAGAG
TTTAATGCTATTTACAGAAATTTAGCGGCGCTTAGACACGGTGCTCCAGATTCCAAAGAGGCGCAAGAAGCTATCAAAGT
ATGGTACGATTACTTGCAAAACTTCAGTCACTATTCATTAGATGCTTTTAAGGGGCTCGGTCAAATGTACGTCGCTGATG
AGCGCTTTACGAAAAATATCGATAAGTTTGGTGAAGGTTTAGCGCAGTTTATGTGCGATGCGATGGAAGTTTATGCGGAT
CGTAATAAATAG

Upstream 100 bases:

>100_bases
ATATCTATTATGCATGAAATATTTTATAAAGAAAATGAATTTACTTATTGACTCTAACGTTGCGTCATACTTTATCGTAT
GTATTAAGGGGGAGATACAC

Downstream 100 bases:

>100_bases
TAAAAAATAAAGAAGGTGGAGGTTTTCTCCGCCTTCTTTATTTTTTTATCATATCATTTAAAGTCTGATCCCCTGTATTG
TTCAAATGAGGATTTTTACT

Product: transcriptional activator

Products: NA

Alternate protein names: Multidrug transporter activation protein [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MAMKVKEVANLVGISVRTLHHYDEIGLLIPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDRKEAL
QLHKKMLLEKRARLDKVIATIDKTIQHTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEE
FNAIYRNLAALRHGAPDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYAD
RNK

Sequences:

>Translated_243_residues
MAMKVKEVANLVGISVRTLHHYDEIGLLIPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDRKEAL
QLHKKMLLEKRARLDKVIATIDKTIQHTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEE
FNAIYRNLAALRHGAPDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYAD
RNK
>Mature_242_residues
AMKVKEVANLVGISVRTLHHYDEIGLLIPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDRKEALQ
LHKKMLLEKRARLDKVIATIDKTIQHTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEF
NAIYRNLAALRHGAPDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADR
NK

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 28239; Mature: 28108

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMKVKEVANLVGISVRTLHHYDEIGLLIPDETTESGYRLYSNENLETLQQILFFKELGF
CCCCHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCC
PLKKIKEIIMSPSFDRKEALQLHKKMLLEKRARLDKVIATIDKTIQHTKGEIEMTNKEKF
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHC
EGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGAPDSKE
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
AQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYAD
HHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNK
CCC
>Mature Secondary Structure 
AMKVKEVANLVGISVRTLHHYDEIGLLIPDETTESGYRLYSNENLETLQQILFFKELGF
CCCHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCC
PLKKIKEIIMSPSFDRKEALQLHKKMLLEKRARLDKVIATIDKTIQHTKGEIEMTNKEKF
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHC
EGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGAPDSKE
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHH
AQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYAD
HHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RNK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]