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The map label for this gene is lytS

Identifier: 49480458

GI number: 49480458

Start: 5188052

End: 5189821

Strand: Reverse

Name: lytS

Synonym: BT9727_5123

Alternate gene names: 49480458

Gene position: 5189821-5188052 (Counterclockwise)

Preceding gene: 49480460

Following gene: 49480457

Centisome position: 99.09

GC content: 36.72

Gene sequence:

>1770_bases
ATGCTAAATTTAGTACTTATGATGATTGAACGCGTCGGACTTATTGTTATTCTAGGATTTTTACTTTCGCATATTAAAAC
ATTCAGGCGCCTTCTTCATAAGCAAGATGGTTATGTAGATAAGCTTAAGCTTATTTGTATTTTTTCGGTGTTTACAATTG
TAAGCAATTACACCGGGATTGAAATAGCAGGGAATACGATTATGAATGAAAATTGGCTACAGGGTGTTTCATCATCGAGT
ACCATTGCAAATACACGTATTATGGGTGTTGGAATTAGTGGATTGCTTGGTGGTCCTATTGTTGGAGTTGGAGTAGGATC
GATTGCTGGTATTCACCGTTATATGCTTGGCGGGACGACAGCGCTAAGTTGCGCAATCTCTTCAATTTTAGCAGGCGTTA
TAACTGGGTATATTGGATACATTTTTAAAAAGTATAATCGTACAATTACGCCTAAATTTTCAGCAGTTTTAAGTGTGTTT
ATCGTTTCTTTAGAAATGATTATGATTCTATTAATTGTAGAGGATGGCATTAGCATTGTGAAAACAATTGCGATACCAAT
GATCCTTGTAAATAGCTTTGGAAGTTTTATTTTACTTTCTATGATACAAGCTATTTTGCGCCAGGAAGAGAACGCAAAGG
CACTTCAGACTCATAAGGTATTACGTATTGCAGATAAAACGTTACCGTATTTTCGCCAAGGCTTAACAGAAGAATCTTGT
AAGCATGTGGCACAAATTATTCACCGCTTTACAGGAACAGATGCGGTATCCTTAACAGATACAGAGAAAATATTAGCTCA
TGTTGGATTAGCGTCAGATCACCATATTCCTTCACATAGTTTAATAACCGGTTTGTCGAAAGAAGTGTTACATACAGGGA
AAATAATGAAAGCGAAATCACGTGAGGTCATTAATTGTCAACATGAAGGCTGTCCTTTGCAAGCGGCGATTGTTATTCCG
CTAACTTCACATGGAAATACGATAGGGACATTAAAACTATATTTCAAAAATCCTAACCAGTTAAGTCGTGTGGAAGAGGA
ATTAGCAGAAGGGTTAGCAAAAATATTCTCTACACAACTTGAATTAGGTGAAGCTGAGTTGCAAAGTAAATTATTGCAAG
ATGCGGAGATAAAGGCATTACAAGCACAAATTAACCCACACTTTTTATTTAATGCGATTAATACAGTATCAGCTTTATGC
CGAACAGATGTAGAAAAAGCAAGGAAGTTATTATTGCAGCTTAGCGTGTATTTCCGTTGTAATTTGCAAGGGGCACGTCA
GTTATTGATTCCACTAGAACAAGAATTAAACCATGTACAGGCATACTTATCACTAGAACAAGCAAGGTTCCCAAATAAGT
ATGAAGTAAAGATGTATATTGAGGATGAGCTCAAGACAACTTTAGTACCACCGTTTGTTCTTCAACTATTGGTTGAAAAT
GCGTTGCGACACGCCTTTCCAAAGAAGCAACCCGTATGTGAAGTGGAAGTGCATGTTTTTGAAAAAGAGGGTATGGTTCA
TTTTGAGGTAAAGGATAATGGGCAAGGTATTGAGGAAGAACGTTTAGAACAATTAGGAAAGATGGTAGTTTCGTCAAAGA
AAGGGACTGGAACAGCTTTATATAATATTAATGAACGTCTTATTGGGTTATTTGGGAAGGAAACGATGCTTCATATCGAA
AGTGAAGTAAATGAGGGGACAGAGATTACTTTTGTTATTCCAAAAAAAGTAGGGGAGGAAGAGCAGATTGTTAAAAGTAC
TAGTAGTTGA

Upstream 100 bases:

>100_bases
TATGTGTAAAATATTGCAAAAGGCATTTCATTCTTCTTGACGCCCACTTCACTATTTTCCGATAATAAAACTAACTACTA
TAAAAAGGAATGAATCACAG

Downstream 100 bases:

>100_bases
TGATGAAATGTTAGCACGTGATGAACTAAAGTATTTATTAGAGAGAACGAAGGAAGTTGAGATCATTGGTGAGGCTGATT
GTGTAGAGGACGCATTAGAA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGVGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSTSS

Sequences:

>Translated_589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGVGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSTSS
>Mature_589_residues
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGIEIAGNTIMNENWLQGVSSSS
TIANTRIMGVGISGLLGGPIVGVGVGSIAGIHRYMLGGTTALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVF
IVSLEMIMILLIVEDGISIVKTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKSREVINCQHEGCPLQAAIVIP
LTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQLELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALC
RTDVEKARKLLLQLSVYFRCNLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTALYNINERLIGLFGKETMLHIE
SEVNEGTEITFVIPKKVGEEEQIVKSTSS

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=582, Percent_Identity=34.5360824742268, Blast_Score=313, Evalue=3e-86,
Organism=Escherichia coli, GI1788446, Length=584, Percent_Identity=32.0205479452055, Blast_Score=273, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65252; Mature: 65252

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
EIAGNTIMNENWLQGVSSSSTIANTRIMGVGISGLLGGPIVGVGVGSIAGIHRYMLGGTT
EEECCCCCCCHHHCCCCCCCCHHHCEEEEECHHHHCCCCEEECCHHHHHHHHHHHHCCHH
ALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVFIVSLEMIMILLIVEDGISIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKS
HHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCC
REVINCQHEGCPLQAAIVIPLTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQL
CCCEECCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALCRTDVEKARKLLLQLSVYFRC
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
NLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCCCHHHHHHHHHH
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTAL
HHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
YNINERLIGLFGKETMLHIESEVNEGTEITFVIPKKVGEEEQIVKSTSS
EECCHHHHHHHCCHHHEEEHHHCCCCCEEEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure
MLNLVLMMIERVGLIVILGFLLSHIKTFRRLLHKQDGYVDKLKLICIFSVFTIVSNYTGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
EIAGNTIMNENWLQGVSSSSTIANTRIMGVGISGLLGGPIVGVGVGSIAGIHRYMLGGTT
EEECCCCCCCHHHCCCCCCCCHHHCEEEEECHHHHCCCCEEECCHHHHHHHHHHHHCCHH
ALSCAISSILAGVITGYIGYIFKKYNRTITPKFSAVLSVFIVSLEMIMILLIVEDGISIV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KTIAIPMILVNSFGSFILLSMIQAILRQEENAKALQTHKVLRIADKTLPYFRQGLTEESC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHH
KHVAQIIHRFTGTDAVSLTDTEKILAHVGLASDHHIPSHSLITGLSKEVLHTGKIMKAKS
HHHHHHHHHHCCCCCEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCHHHHCCC
REVINCQHEGCPLQAAIVIPLTSHGNTIGTLKLYFKNPNQLSRVEEELAEGLAKIFSTQL
CCCEECCCCCCCEEEEEEEEEECCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ELGEAELQSKLLQDAEIKALQAQINPHFLFNAINTVSALCRTDVEKARKLLLQLSVYFRC
HCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
NLQGARQLLIPLEQELNHVQAYLSLEQARFPNKYEVKMYIEDELKTTLVPPFVLQLLVEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCCCHHHHHHHHHH
ALRHAFPKKQPVCEVEVHVFEKEGMVHFEVKDNGQGIEEERLEQLGKMVVSSKKGTGTAL
HHHHCCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEE
YNINERLIGLFGKETMLHIESEVNEGTEITFVIPKKVGEEEQIVKSTSS
EECCHHHHHHHCCHHHEEEHHHCCCCCEEEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]