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The map label for this gene is ung

Identifier: 49480441

GI number: 49480441

Start: 5139669

End: 5140346

Strand: Reverse

Name: ung

Synonym: BT9727_5079

Alternate gene names: 49480441

Gene position: 5140346-5139669 (Counterclockwise)

Preceding gene: 49481304

Following gene: 49478984

Centisome position: 98.14

GC content: 36.73

Gene sequence:

>678_bases
GTGAAACATGTTTTGAAAAATGATTGGGGGCTGTTATTGGCACCAGAATTTGAGAAAGAATATTATCGCGAGTTGGATGT
TTTTTTGAAGGAAGAGTACAGTATACATGTTGTTTATCCAAAGATAGAAGATATCTTTAACGCTCTAGAGTATACAAGTT
ATGAAAATACAAAGGTCGTTATTTTAGGACAAGACCCATATCATGGGCCGAATCAAGCGCATGGTTTAAGCTTTTCTGTA
CAACCTGGTGTTAAAACGCCACCGTCATTGTTAAATATGTATAAAGAGCTTCGAGATGAATATGGGTATGACATTCCGAA
TAACGGTTATTTAGTGAAATGGGCAGAGCAAGGAGTATTACTACTAAATACTGTATTAACAGTTCGACAAGGCGAAGCAA
ATTCTCATAAGGGAAAAGGATGGGAGCATTTCACTGATCGTGTAATTGAGCTGTTGAATGAACGTGAAAAACCAGTTATT
TTCATATTGTGGGGACGCCATGCACAGGCGAAGAAGAAGTTAATTACAAATTCAAATCATCATATTATCGAATCTGTACA
TCCAAGCCCACTATCAGCAAGACGAGGTTTCTTTGGGAGTAAGCCATACTCTAAAGTAAATACGATTTTAGCTAATATGG
GCGAGAGAGAAATTGATTGGGAAATTCCAAATTTATAA

Upstream 100 bases:

>100_bases
TTAATGAATTTAACTGTTTGGGGAATTGTATCTCTTATTATTTCGTTTGTAGTATTTACAAAGCAGGATATGGTGAATTA
ATTAGACGGGAAGTGAAAGT

Downstream 100 bases:

>100_bases
ATAGAAAAGGTAGTTAACAGTCGTTAACTACCTTTTTATTATTGTTGTTCGTTCTTTAATTTTGCATCTAGTACAAACGT
ACCAAATGGGATAACTGATG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKHVLKNDWGLLLAPEFEKEYYRELDVFLKEEYSIHVVYPKIEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGVKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNSNHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL

Sequences:

>Translated_225_residues
MKHVLKNDWGLLLAPEFEKEYYRELDVFLKEEYSIHVVYPKIEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGVKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNSNHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
>Mature_225_residues
MKHVLKNDWGLLLAPEFEKEYYRELDVFLKEEYSIHVVYPKIEDIFNALEYTSYENTKVVILGQDPYHGPNQAHGLSFSV
QPGVKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVI
FILWGRHAQAKKKLITNSNHHIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=50.2325581395349, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=50.2325581395349, Blast_Score=216, Evalue=1e-56,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=53.7383177570093, Blast_Score=235, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.6111111111111, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=236, Percent_Identity=45.7627118644068, Blast_Score=194, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26045; Mature: 26045

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVLKNDWGLLLAPEFEKEYYRELDVFLKEEYSIHVVYPKIEDIFNALEYTSYENTKVV
CCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGVKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNSNH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCC
HIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
EEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure
MKHVLKNDWGLLLAPEFEKEYYRELDVFLKEEYSIHVVYPKIEDIFNALEYTSYENTKVV
CCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCCEEE
ILGQDPYHGPNQAHGLSFSVQPGVKTPPSLLNMYKELRDEYGYDIPNNGYLVKWAEQGVL
EECCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEE
LLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNSNH
EEHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCC
HIIESVHPSPLSARRGFFGSKPYSKVNTILANMGEREIDWEIPNL
EEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA