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The map label for this gene is acdA [H]

Identifier: 49480422

GI number: 49480422

Start: 5074899

End: 5076038

Strand: Reverse

Name: acdA [H]

Synonym: BT9727_5025

Alternate gene names: 49480422

Gene position: 5076038-5074899 (Counterclockwise)

Preceding gene: 49481208

Following gene: 49480421

Centisome position: 96.91

GC content: 43.6

Gene sequence:

>1140_bases
ATGCATTTTAAACTATCAGAAGAACATGAAATGATAAGAAAAATGGTTCGGGATTTTGCTAAGAATGAAGTAGCACCAAC
AGCAGCCGAGCGTGATGAAGAAGAGAGATTTGATCGTGCACTATTTGATCAAATGGCAGAGCTTGGTTTAACCGGAATTC
CGTGGCCTGAAGAATACGGCGGAATTGGAAGCGATTACTTAGCTTATGTAATTGCTATTGAAGAATTATCACGCGTATGT
GCTTCTACAGGTGTAACATTGTCTGCACATACTTCACTTGCTGGTTGGCCAATTTTTAAATTTGGAACTGAAGAGCAAAA
GCAAACGTTTTTACGACCAATGGCTGAAGGAAAGAAAATTGGTGCATACGGGTTAACGGAGCCGGGATCTGGATCGGATG
CTGGTGGAATGAAGACAATCGCCAAAAGAGATGGAGACCATTACGTTTTAAATGGATCGAAAATATTTATTACAAATGGC
GGTATTGCCGACATTTATGTTGTTTTCGCGTTAACTGATCCTGAATCGAAGCAGCGTGGCACGAGCGCGTTTATTGTGGA
AAGTGATGCACCAGGATTCTCAGTTGGGAAGAAGGAAAGTAAGTTAGGGATTCGTTCTTCGCCAACAACTGAAATTATGT
TCGAAGATTGCCGCATTCCTGTAGAGAATTTACTAGGGGAAGAAGGACAAGGGTTTAAGATAGCGATGCAAACATTAGAT
GGGGGTCGTAACGGTATTGCAGCGCAAGCAGTGGGTATTGCACAAGGGGCTTTAGATGCGTCCGTAGCATATGCAAGAGA
GCGCCATCAGTTTGGGAAGCCAATTGCGGCGCAACAAGGAATTGGCTTTAAACTTGCAGATATGGCAACGGATGTGGAGG
CAGCGCGCCTTCTAACATACCAAGCAGCTTGGCTGGAATCGGAAGGGCTTCCGTATGGGAAAGAGTCAGCGATGTCAAAA
GTATTTGCAGGCGATGCAGCGATGAAGGTGACGACTGAAGCGGTACAAGTATTTGGTGGTTACGGTTATACGAAAGATTA
TCCAGTAGAGCGTTATATGCGAGATGCAAAGATTACACAAATATATGAAGGAACACAAGAGATTCAAAGGCTCGTAATTT
CTCGTATGTTAACGAAGTAG

Upstream 100 bases:

>100_bases
TTTCCGTGATGCGAAAATCACGCAAATATATGAAGGAACGAGTGAAATACAGAAACTTGTTATTAGCCGAGCTTTATAAA
AGCACAAGGGGGAGACGGAC

Downstream 100 bases:

>100_bases
GATCGAAGGCGTAGGTATTTTCCTACGCTTTTTCCTTCCAAAAAATAATAGAGGGGTGAAGGGGATGGTTAAACATAATG
TGCACGCATCAGTGAAAGAT

Product: butyryl-CoA dehydrogenase (short-chain acyl-CoA dehydrogenase)

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRALFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Sequences:

>Translated_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRALFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK
>Mature_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRALFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=53.7234042553192, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=42.7821522309711, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=43.0851063829787, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=43.5013262599469, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=43.5013262599469, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=40.5835543766578, Blast_Score=288, Evalue=4e-78,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=40.8695652173913, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=42.7350427350427, Blast_Score=261, Evalue=6e-70,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=36.3636363636364, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=32.010582010582, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=31.6939890710383, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI48976061, Length=295, Percent_Identity=31.1864406779661, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=31.1864406779661, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=30.9027777777778, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=30.9711286089239, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=30.2083333333333, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081702, Length=315, Percent_Identity=27.3015873015873, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=28.7822878228782, Blast_Score=88, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=42.7807486631016, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.1443569553806, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=41.2868632707775, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=45.4308093994778, Blast_Score=310, Evalue=6e-85,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=41.3157894736842, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.0501319261214, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=39.6825396825397, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=43.1506849315069, Blast_Score=250, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=39.5095367847411, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=32.8912466843501, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=37.3134328358209, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=43.4782608695652, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=39.4904458598726, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.5483028720627, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17505929, Length=379, Percent_Identity=31.6622691292876, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.8547717842324, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17562446, Length=291, Percent_Identity=28.8659793814433, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=29.608938547486, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563381, Length=310, Percent_Identity=26.4516129032258, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=310, Percent_Identity=26.4516129032258, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=52.5333333333333, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=47.2, Blast_Score=351, Evalue=4e-97,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=41.6, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=43.3862433862434, Blast_Score=310, Evalue=8e-85,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=38.5826771653543, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=38.60103626943, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=34.2931937172775, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24652780, Length=324, Percent_Identity=24.6913580246914, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41342; Mature: 41342

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRALFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRALFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]