Click here to switch to the map view.

The map label for this gene is acr3

Identifier: 49480092

GI number: 49480092

Start: 3042603

End: 3043643

Strand: Reverse

Name: acr3

Synonym: BT9727_2964

Alternate gene names: 49480092

Gene position: 3043643-3042603 (Counterclockwise)

Preceding gene: 49479113

Following gene: 49478069

Centisome position: 58.11

GC content: 36.22

Gene sequence:

>1041_bases
ATGAAACGTTTATCTTTTCTAGACCGATATTTAACACTATGGATTTTTCTAGCGATGGCTGTTGGGATTGGTTTAGGGTT
TGTGTTCCCTAGTGTAGTAGACGGACTGAATACATTACAAGTTGGCACGACGTCTATTCCGCTTGCAGTTGGTTTAATTG
TAATGATGTATCCACCATTAGCGAAAGTTCGCTATGAGGAAATGGGCCGAGTATTTAAAGATGTTAAAGTGTTAGTTCTA
TCTTTAGTACAAAACTGGATTATTGGTCCGGTACTTATGTTTGTGTTAGCAATTATTTTTCTCCCTGATAAACCAGAATA
CATGGTCGGTCTCATTATGATTGGATTAGCACGTTGCATTGCAATGGTCATTGTTTGGAATGATCTAGCTGATGGTGATA
AAGAGTATGCGGCAGGTTTAGTGGCTTTTAACTCGGTATTCCAAATGCTCTTTTTCTCGGTTTATGCATACGTATTTGTA
ACAGTCATTCCAGAATGGTTAGGGATTGAAGGGGCTATTGTCGATATTACAATGATAGAAGTAGCAAAATCAGTATGTAT
CTATTTAGGAATTCCTTTTATAGCAGGTATGTTGACACGCTTTGTACTCGTGAAGTTAAAAGGAAGACAGTGGTATGAAA
AGGTGTTTATACCTAAGATTAGTCCACTTACATTGATTGCATTGCTATTTACGATCATCATTATGTTTTCTTTAAAAGGA
GAGATGATTGTTAGTGTACCACTAGATGTAGTAAGAATAGCAATTCCATTACTCATTTATTTTATTGTAATGTTTTTTGT
TTCTTTCTTTATGGGAAGAAAGATTGGTGCAAACTATCCGGTAACAACAACGTTAGCATTTACAGCAGGTAGTAATAACT
TTGAATTAGCGATTGCTGTAGCAGTTGGTGTGTTTGGTATTCATTCGGGCGCAGCATTTGCAGCTGTTATCGGTCCTTTA
GTTGAAGTACCTGTCATGATTGCACTTGTAAACGTTGCTTTTTGGTTTAAACGTAAATATTTTAATGATCAATCAGTCTA
A

Upstream 100 bases:

>100_bases
AGCACATAGTGATGTTCACAAAATTGAAGAGTCATCTTGTTGTACGACTTCTAATGAAGTAGCTAAAAATTCTTGTTGTT
AATAGGAGATGGAAAATAAA

Downstream 100 bases:

>100_bases
ATTTAAAAATAAAGGTGGAAAACAACATGGAGAACAAAAAGACAATCTACTTTTTATGTACAGGAAATTCATGCCGAAGC
CAAATGGCAGAAGCATGGGG

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVCIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV

Sequences:

>Translated_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVCIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV
>Mature_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVCIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=334, Percent_Identity=36.5269461077844, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38380; Mature: 38380

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVCIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVCIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]