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The map label for this gene is moeA

Identifier: 49479255

GI number: 49479255

Start: 3395763

End: 3397070

Strand: Reverse

Name: moeA

Synonym: BT9727_3324

Alternate gene names: 49479255

Gene position: 3397070-3395763 (Counterclockwise)

Preceding gene: 49478275

Following gene: 49479257

Centisome position: 64.86

GC content: 39.3

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAAGTAATGGGATTTGCTAATGAGGGTTTAAAGGAGCT
ACTACCTATTGAATTAGCTTACGGACGTGTATTAGCGGAGGATTTAGTAGCTGACCATGACGTACCTTCATTCAATCGTT
CACCGTATGACGGATTTGCTATTAGAGCAGAAGATACGAATGTAGCAAGTTATGAAACACCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCAATGAGAAAGTAGGTCCGTTTCAAGCAGTTCGAATTATGACGGGAGCGCAAAT
TCCGAATGGATGTGATGCAGTTGTTATGCTAGAGCTGACTCGTCAATATGAGGAGGCTGTCAGTAAGTATATGGAATTGA
AGCGGTCATTCAAAGCGGGCGATAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACGGTTCTTGCAAAGAAAGGA
ACATACATTAATCCAGGTATTTCAGCTCTTCTTGCTACATTCGGGTATAGCGAGGTGCCAGTTGCGAGAAAGCCTGTAGT
TGGACTATTAGCGACTGGCAGTGAATTACTGGATGTAAACGATTCATTACAGCCAGGGGAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATCCGAAGAGCAGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGATGATTTTCATACGTGT
TTTACGGCTGTAAAAGAAGCATTAAGCCAAGTAGATATGCTCATTACAACAGGTGGTGTATCAGTAGGGGATTACGATTA
TTTGCCAGCTATATATGAAAAATTAGGTGCATCAGTTCTTTTCAATAAAGTTGCAATGCGGCCAGGAAGTGTAACGACTG
TAGCGCAATTAAATGGAAAGTTATTATTTGGTTTATCAGGAAATCCATCTGCTTGTTACGTAGGGTTTGAATTGTTTGTA
AGACCTTGTATTCGGACGTATATGTTTAGTGAAAAAGCACATGTAAAAAGAGAAAAAGCGTTATTAGGAGAAGACTTTTT
AAAGCCAAATCCATTTACAAGGTTTGTACGAGGAAAACTAACATATAACGAAGGGCAGTTAATCGCTTATCCGTCAGGGT
TTGATAAATCTAGCTCAGTTTCCTCTCTAGCGGAGACAAATATATTTATTGTACTTCCAGGTGGTACGAGAGGTTATAAA
AAAGATATGTTCGTAGATGTGCTCTTGTTGGAAGATAACGAAGGTAGTGAGTGGCCTTGGACATTTTATAAAGTGAGAGG
TGATTCTAATGGGACAAGTGCTATTTGA

Upstream 100 bases:

>100_bases
TTTTCGAGATGGTCGTGTTTTCATTCATGGTACAAATGATATTTTAAAAGCAAAACAGTTATATTATCGCGTATTCGGTT
AATAGAAAGGGTTGTCAATA

Downstream 100 bases:

>100_bases
AATTGTAGATATACCGATTGTAGTTGAAGAAGTAACGAATAAGGTTGCAAGAAGAGAAGCAGGTGCGATTACAACTTTTA
TTGGTACAGTGAGAGAATTA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKVMGFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFNEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAVSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGEIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKVMGFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFNEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAVSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGEIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI
>Mature_435_residues
MERRVPITVEEAVRKVMGFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFAIRAEDTNVASYETPIVFEVV
GEIGAGSLFNEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEEAVSKYMELKRSFKAGDNISFQGEDARKGTVLAKKG
TYINPGISALLATFGYSEVPVARKPVVGLLATGSELLDVNDSLQPGEIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKLTYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGDSNGTSAI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=391, Percent_Identity=35.0383631713555, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI10880983, Length=390, Percent_Identity=35.1282051282051, Blast_Score=199, Evalue=6e-51,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=34.8648648648649, Blast_Score=188, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI25147659, Length=397, Percent_Identity=28.7153652392947, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=393, Percent_Identity=27.9898218829517, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136978, Length=366, Percent_Identity=28.1420765027322, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24638841, Length=366, Percent_Identity=28.1420765027322, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47773; Mature: 47773

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKVMGFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFA
CCCCCCCCHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNVASYETPIVFEVVGEIGAGSLFNEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCHHHCCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAVSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGEIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKVMGFANEGLKELLPIELAYGRVLAEDLVADHDVPSFNRSPYDGFA
CCCCCCCCHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNVASYETPIVFEVVGEIGAGSLFNEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCHHHCCCCCHHEEEEEECCCCCCCCCCEEHHHHH
RQYEEAVSKYMELKRSFKAGDNISFQGEDARKGTVLAKKGTYINPGISALLATFGYSEVP
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHCCCCCCC
VARKPVVGLLATGSELLDVNDSLQPGEIRNSNTYMILSQIRRAGGRVKYFGKFSDDFHTC
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCEEHHHHHHHCCCCEEEEECCCCHHHHH
FTAVKEALSQVDMLITTGGVSVGDYDYLPAIYEKLGASVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPCIRTYMFSEKAHVKREKALLGEDFLKPNPFTRFVRGKL
EEEEECCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEE
TYNEGQLIAYPSGFDKSSSVSSLAETNIFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCEEEEECCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGDSNGTSAI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]