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The map label for this gene is yhcY [H]

Identifier: 49478990

GI number: 49478990

Start: 5151998

End: 5153569

Strand: Reverse

Name: yhcY [H]

Synonym: BT9727_5092

Alternate gene names: 49478990

Gene position: 5153569-5151998 (Counterclockwise)

Preceding gene: 49480448

Following gene: 49481286

Centisome position: 98.39

GC content: 35.31

Gene sequence:

>1572_bases
ATGTTTCAAGAGAATCGTACAAATGAATTAGTTATATTAAAAGAGATTGCAGAAACGCTAAATACATCAAATGATACATA
CCATGTATTGCAAGCAGTGCTAGAAAAATTACTTAGTGTAACAGGTTTAATGACAGGATGGATATTTCTTGCGGATGAAA
ATGGTAGATATACAAAATTAATTGATTATCAATTACCAGAGGCACTTACATATGAAAATAAACGCCCGATGTGTGAAGGG
GAATGTTGGTGTTTACGTGGCTTTGTGGATGGAAAGTTAGAGAGAGCTGTTAATATTATTGAATGTAAAAGAATTAATAA
TGCAATTGAATATAATTGGGGAGATACAGAAGGGATTCTTCATCATGCTACGGTTCCTTTAAAGGCTGGAGGAGAAAAAT
TTGGTTTGTTAAATGTGGCAAGCCCAGGTAAAACACATTTTTCAGAAGAAGAATTAGTATTGCTTCAATCAGTTGCTTTC
CAAATTGGAACGGCTTTAAAACGAGCAAAGTTATATGAAAATGAAAAGCGAAGAGCGCATTATTATGTGAAATTAGAACG
TTTCATTCAAGTTTTAAGAACGATTCATCAATTTAATATATTGCCTGAAAAAGTTGTAAATCAATTAGGTGAAGTATTTC
AGTGGAATCAAGTGGCGTTTTTTATTAGGGAAGAGAAAGAATTATCTTTGCGGGCATCTTATTGCCAGGAAGAATTGCAC
GAGGATATAAAAGAAGCAGCGAAAGAAGCATTAGAAAAAGGTGAACTTATTTTATTAAACGATCAAATCAGTCATAAGGT
AGCCTCTAATAGAACGGTTATTGCCACACCAATACAGATTCAAACTCACATATTTGGTGTTTTATGTGTTAGTTCAAATC
ATGGTGAATTTGATGTGAATACGATAGATGTACTTCAAGCAATAACAAATCATATTTCCTTCGTGATAGAAAATTTAAGG
TTAAATGAGCAACGACGCGAACTTGTACGAATGGAAGAAAGAAATCGGTTAGCAAGGGACTTACATGATTCCGTCTCACA
AAAGCTATTTTCGTTAACCTTTATGACAAAGGGCGCTGAGGCAGTCTTAAAAGGTCAAAATGAAAAGGTGGACCGATCTT
TGCATGAGATGCGTGAACTAGCGCAAGGAGCTTTAAAAGAAATGAGGACGTTGATTTGGCAACTACGTCCAGCAGGTTTA
GAGAAAGGATTATTACCAGCTTTAAAGCAATATGGTGAAAGTTTGGGGTTGAAAATTCGGGAACAAGTTACAGGTGTCCG
AGATTTACCGCGCGTAGTAGAGGAAGCGTTATGGAGAATTGGACAAGAAGCTTTAAATAACGTAAGTAAGCATGCGAATG
TTAGAGAAGCGACGATTTATTTCAAAGTGACCGAGAAGAATGTATCATTAGAAATAGTCGATCAAGGAAACGGCTTTGTA
GAAAAGAATATAAAAGAGAAGAAATCACTTGGCATGACTACGATGCGCGAAAGAGTAGAATTAGTCGGTGGAACAATTAA
AATTGTAAGTGATAAAAAAAGAACAAGTGTAAAAGTAAACGTACCATTATGA

Upstream 100 bases:

>100_bases
ATGTTTTCACCATTATATCAATGTTATGAATAAGTACAAAGTGAAAAGTAGATGATTTATGTTAGGAACTATGTAAAATC
TTGTATGTAGGAGACGAATT

Downstream 100 bases:

>100_bases
TGTGAAAATGAGGGAAGTTTGTGAAAATAAAAGTATTATTAGTTGATGATCATACAGTCGTTTTAAAAGGATTAGCATTT
TTCTTAAGTACACAGGAAGA

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MFQENRTNELVILKEIAETLNTSNDTYHVLQAVLEKLLSVTGLMTGWIFLADENGRYTKLIDYQLPEALTYENKRPMCEG
ECWCLRGFVDGKLERAVNIIECKRINNAIEYNWGDTEGILHHATVPLKAGGEKFGLLNVASPGKTHFSEEELVLLQSVAF
QIGTALKRAKLYENEKRRAHYYVKLERFIQVLRTIHQFNILPEKVVNQLGEVFQWNQVAFFIREEKELSLRASYCQEELH
EDIKEAAKEALEKGELILLNDQISHKVASNRTVIATPIQIQTHIFGVLCVSSNHGEFDVNTIDVLQAITNHISFVIENLR
LNEQRRELVRMEERNRLARDLHDSVSQKLFSLTFMTKGAEAVLKGQNEKVDRSLHEMRELAQGALKEMRTLIWQLRPAGL
EKGLLPALKQYGESLGLKIREQVTGVRDLPRVVEEALWRIGQEALNNVSKHANVREATIYFKVTEKNVSLEIVDQGNGFV
EKNIKEKKSLGMTTMRERVELVGGTIKIVSDKKRTSVKVNVPL

Sequences:

>Translated_523_residues
MFQENRTNELVILKEIAETLNTSNDTYHVLQAVLEKLLSVTGLMTGWIFLADENGRYTKLIDYQLPEALTYENKRPMCEG
ECWCLRGFVDGKLERAVNIIECKRINNAIEYNWGDTEGILHHATVPLKAGGEKFGLLNVASPGKTHFSEEELVLLQSVAF
QIGTALKRAKLYENEKRRAHYYVKLERFIQVLRTIHQFNILPEKVVNQLGEVFQWNQVAFFIREEKELSLRASYCQEELH
EDIKEAAKEALEKGELILLNDQISHKVASNRTVIATPIQIQTHIFGVLCVSSNHGEFDVNTIDVLQAITNHISFVIENLR
LNEQRRELVRMEERNRLARDLHDSVSQKLFSLTFMTKGAEAVLKGQNEKVDRSLHEMRELAQGALKEMRTLIWQLRPAGL
EKGLLPALKQYGESLGLKIREQVTGVRDLPRVVEEALWRIGQEALNNVSKHANVREATIYFKVTEKNVSLEIVDQGNGFV
EKNIKEKKSLGMTTMRERVELVGGTIKIVSDKKRTSVKVNVPL
>Mature_523_residues
MFQENRTNELVILKEIAETLNTSNDTYHVLQAVLEKLLSVTGLMTGWIFLADENGRYTKLIDYQLPEALTYENKRPMCEG
ECWCLRGFVDGKLERAVNIIECKRINNAIEYNWGDTEGILHHATVPLKAGGEKFGLLNVASPGKTHFSEEELVLLQSVAF
QIGTALKRAKLYENEKRRAHYYVKLERFIQVLRTIHQFNILPEKVVNQLGEVFQWNQVAFFIREEKELSLRASYCQEELH
EDIKEAAKEALEKGELILLNDQISHKVASNRTVIATPIQIQTHIFGVLCVSSNHGEFDVNTIDVLQAITNHISFVIENLR
LNEQRRELVRMEERNRLARDLHDSVSQKLFSLTFMTKGAEAVLKGQNEKVDRSLHEMRELAQGALKEMRTLIWQLRPAGL
EKGLLPALKQYGESLGLKIREQVTGVRDLPRVVEEALWRIGQEALNNVSKHANVREATIYFKVTEKNVSLEIVDQGNGFV
EKNIKEKKSLGMTTMRERVELVGGTIKIVSDKKRTSVKVNVPL

Specific function: Member of the two-component regulatory system yhcY/yhcZ. Probably activates yhcZ by phosphorylation [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=197, Percent_Identity=27.4111675126904, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788812, Length=240, Percent_Identity=26.25, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 59797; Mature: 59797

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQENRTNELVILKEIAETLNTSNDTYHVLQAVLEKLLSVTGLMTGWIFLADENGRYTKL
CCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEE
IDYQLPEALTYENKRPMCEGECWCLRGFVDGKLERAVNIIECKRINNAIEYNWGDTEGIL
EECCCCHHHCCCCCCCCCCCCCEEEECHHCHHHHHHHHHHHHHHCCCCEEECCCCCCCCE
HHATVPLKAGGEKFGLLNVASPGKTHFSEEELVLLQSVAFQIGTALKRAKLYENEKRRAH
EECCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYVKLERFIQVLRTIHQFNILPEKVVNQLGEVFQWNQVAFFIREEKELSLRASYCQEELH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHH
EDIKEAAKEALEKGELILLNDQISHKVASNRTVIATPIQIQTHIFGVLCVSSNHGEFDVN
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCCEEEEECCEEEEEEEEEEEEECCCCCCCCH
TIDVLQAITNHISFVIENLRLNEQRRELVRMEERNRLARDLHDSVSQKLFSLTFMTKGAE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AVLKGQNEKVDRSLHEMRELAQGALKEMRTLIWQLRPAGLEKGLLPALKQYGESLGLKIR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHH
EQVTGVRDLPRVVEEALWRIGQEALNNVSKHANVREATIYFKVTEKNVSLEIVDQGNGFV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEECCCCCH
EKNIKEKKSLGMTTMRERVELVGGTIKIVSDKKRTSVKVNVPL
HHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MFQENRTNELVILKEIAETLNTSNDTYHVLQAVLEKLLSVTGLMTGWIFLADENGRYTKL
CCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEE
IDYQLPEALTYENKRPMCEGECWCLRGFVDGKLERAVNIIECKRINNAIEYNWGDTEGIL
EECCCCHHHCCCCCCCCCCCCCEEEECHHCHHHHHHHHHHHHHHCCCCEEECCCCCCCCE
HHATVPLKAGGEKFGLLNVASPGKTHFSEEELVLLQSVAFQIGTALKRAKLYENEKRRAH
EECCCEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
YYVKLERFIQVLRTIHQFNILPEKVVNQLGEVFQWNQVAFFIREEKELSLRASYCQEELH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHH
EDIKEAAKEALEKGELILLNDQISHKVASNRTVIATPIQIQTHIFGVLCVSSNHGEFDVN
HHHHHHHHHHHHCCCEEEECCHHHHHHHCCCEEEEECCEEEEEEEEEEEEECCCCCCCCH
TIDVLQAITNHISFVIENLRLNEQRRELVRMEERNRLARDLHDSVSQKLFSLTFMTKGAE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
AVLKGQNEKVDRSLHEMRELAQGALKEMRTLIWQLRPAGLEKGLLPALKQYGESLGLKIR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHH
EQVTGVRDLPRVVEEALWRIGQEALNNVSKHANVREATIYFKVTEKNVSLEIVDQGNGFV
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEEECCCCCH
EKNIKEKKSLGMTTMRERVELVGGTIKIVSDKKRTSVKVNVPL
HHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]