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The map label for this gene is vanY

Identifier: 49478788

GI number: 49478788

Start: 4627826

End: 4628686

Strand: Reverse

Name: vanY

Synonym: BT9727_4581

Alternate gene names: 49478788

Gene position: 4628686-4627826 (Counterclockwise)

Preceding gene: 49478655

Following gene: 49480740

Centisome position: 88.37

GC content: 33.45

Gene sequence:

>861_bases
ATGAAAAAGTGGGTATTTATTTCTTTTTTTATCGCATGCACAATCTGTGTAGGCGTTTATATATCACCGTTATTTCAAAA
GGAAATTGATGTGAAAATTGGCGGGGAAAATGGTGCAGTAAAGAATGCAAATATAGAAAAGATAGAGGTTACAAAAGAAC
AAATTTATAAAGGGGATCTATTATTAGTTAACAAAGATTATCCAGTAAAAAAAGAGAGTATTAGGTCCGATATTATAAAT
GTAAATCATAATAGTGAATTAGTAAGGGGCTATGTAATATTTGATAGAAACCTTCGTTTATCAAAGGATGTTGTAAAAAA
GTTTTTGAACGTGGTCGATGCGGCTGGAAAAGATGGTGTACAACATTTCTTAATGAATAGCGGGTATCGAGATTTTAAAG
AGCAAAGTAAATTATATAAAGAAATGGGATCAGATTATGCACTTCCAGCAGGATATAGTGAACATAATTTAGGATTATCA
CTGGACGTTGGTTCAACGCAAAAGAAAATGGAAAAAGCGCCTGAAGGAAAATGGATTGAAGAGAATGTATGGAAGTACGG
ATTTGTATTACGTTATCCGAAAAATAAAAGTCATATTACAGGCATTCAATATGAACCGTGGCACATTCGTTATGTCGGCT
TGCCTCATAGTGCGATTATGCAAAAAAAGAAAATGACATTAGAGGAATATTTAGACTTCTTAAAAGAGAAAAAAGAAATC
ACAACCGATGTGGAAGGTACGAAATATACGGTTTCTTATTATAAAGTTTCAGGGAATATGAAAGTGAACGTTCCAGTGAA
TAAGCAGTATGAAATTTCCGGGAATAATATGGACGGGGTTATTGTGACGGTTCAGGAATAG

Upstream 100 bases:

>100_bases
AAGAAGTTGACAATTTAATAAAAATTTAAACTTTACCCCACTTTTTATTTTAATAGTTTTTTCTATTCTAGACGTAAGTT
ACGTTAAGGAGGAACTAGAA

Downstream 100 bases:

>100_bases
AAAAAGAGGTTGTTCCGCTTTGGAGCGACCTTTTCGTATATAAGAAAGGGATGGCGTTTTTTGTCGGTAAATCGATATTC
CTTGTCGAATCGTTGATATA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKKWVFISFFIACTICVGVYISPLFQKEIDVKIGGENGAVKNANIEKIEVTKEQIYKGDLLLVNKDYPVKKESIRSDIIN
VNHNSELVRGYVIFDRNLRLSKDVVKKFLNVVDAAGKDGVQHFLMNSGYRDFKEQSKLYKEMGSDYALPAGYSEHNLGLS
LDVGSTQKKMEKAPEGKWIEENVWKYGFVLRYPKNKSHITGIQYEPWHIRYVGLPHSAIMQKKKMTLEEYLDFLKEKKEI
TTDVEGTKYTVSYYKVSGNMKVNVPVNKQYEISGNNMDGVIVTVQE

Sequences:

>Translated_286_residues
MKKWVFISFFIACTICVGVYISPLFQKEIDVKIGGENGAVKNANIEKIEVTKEQIYKGDLLLVNKDYPVKKESIRSDIIN
VNHNSELVRGYVIFDRNLRLSKDVVKKFLNVVDAAGKDGVQHFLMNSGYRDFKEQSKLYKEMGSDYALPAGYSEHNLGLS
LDVGSTQKKMEKAPEGKWIEENVWKYGFVLRYPKNKSHITGIQYEPWHIRYVGLPHSAIMQKKKMTLEEYLDFLKEKKEI
TTDVEGTKYTVSYYKVSGNMKVNVPVNKQYEISGNNMDGVIVTVQE
>Mature_286_residues
MKKWVFISFFIACTICVGVYISPLFQKEIDVKIGGENGAVKNANIEKIEVTKEQIYKGDLLLVNKDYPVKKESIRSDIIN
VNHNSELVRGYVIFDRNLRLSKDVVKKFLNVVDAAGKDGVQHFLMNSGYRDFKEQSKLYKEMGSDYALPAGYSEHNLGLS
LDVGSTQKKMEKAPEGKWIEENVWKYGFVLRYPKNKSHITGIQYEPWHIRYVGLPHSAIMQKKKMTLEEYLDFLKEKKEI
TTDVEGTKYTVSYYKVSGNMKVNVPVNKQYEISGNNMDGVIVTVQE

Specific function: Vancomycin-inducible, penicillin-resistant, DD- carboxypeptidase that hydrolyzes depsipeptide- and D-alanyl-D- alanine-containing peptidoglycan precursors. Insensitive to beta- lactams [H]

COG id: COG1876

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M15B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003709 [H]

Pfam domain/function: PF02557 VanY [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 32833; Mature: 32833

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWVFISFFIACTICVGVYISPLFQKEIDVKIGGENGAVKNANIEKIEVTKEQIYKGDL
CCCEEEHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECCCCEEEEECHHHHCCCCE
LLVNKDYPVKKESIRSDIINVNHNSELVRGYVIFDRNLRLSKDVVKKFLNVVDAAGKDGV
EEEECCCCCCHHHHHHHEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHH
QHFLMNSGYRDFKEQSKLYKEMGSDYALPAGYSEHNLGLSLDVGSTQKKMEKAPEGKWIE
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCH
ENVWKYGFVLRYPKNKSHITGIQYEPWHIRYVGLPHSAIMQKKKMTLEEYLDFLKEKKEI
HHHCEEEEEEECCCCCCCEECEEECCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHH
TTDVEGTKYTVSYYKVSGNMKVNVPVNKQYEISGNNMDGVIVTVQE
CCCCCCCEEEEEEEEEECCEEEEECCCCEEEECCCCCCEEEEEEEC
>Mature Secondary Structure
MKKWVFISFFIACTICVGVYISPLFQKEIDVKIGGENGAVKNANIEKIEVTKEQIYKGDL
CCCEEEHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECCCCEEEEECHHHHCCCCE
LLVNKDYPVKKESIRSDIINVNHNSELVRGYVIFDRNLRLSKDVVKKFLNVVDAAGKDGV
EEEECCCCCCHHHHHHHEEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHH
QHFLMNSGYRDFKEQSKLYKEMGSDYALPAGYSEHNLGLSLDVGSTQKKMEKAPEGKWIE
HHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCH
ENVWKYGFVLRYPKNKSHITGIQYEPWHIRYVGLPHSAIMQKKKMTLEEYLDFLKEKKEI
HHHCEEEEEEECCCCCCCEECEEECCEEEEEEECCHHHHHHHHHCCHHHHHHHHHHHHHH
TTDVEGTKYTVSYYKVSGNMKVNVPVNKQYEISGNNMDGVIVTVQE
CCCCCCCEEEEEEEEEECCEEEEECCCCEEEECCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1398115; 8380148 [H]