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The map label for this gene is napA

Identifier: 49478743

GI number: 49478743

Start: 4529739

End: 4530962

Strand: Reverse

Name: napA

Synonym: BT9727_4474

Alternate gene names: 49478743

Gene position: 4530962-4529739 (Counterclockwise)

Preceding gene: 49481402

Following gene: 49481565

Centisome position: 86.51

GC content: 38.56

Gene sequence:

>1224_bases
ATGGATACTTTAATCTTTGAAGTTGGAACTGCGTTAGTATTAGTAGCTTTTGCAGCTATCCTCGCTGCAAAGTTAAAGTT
TTCGATTATTCCGTTTCTCATTATCCTTGGTATGTTAGTGGGACCTCATGCCCCAGATCTAGGACTTATCGATTTAAGGT
TTATTGAAAGCGGAGAAGTTATTTCCTTCCTCGGCCGCGTTGGCGTCATATTCCTCCTATTCTACTTAGGTTTAGAATTC
TCAATAAAAAAATTAATTAAATCAGGAAAATCAATTGCTTTTGGGGGGACTGTCCACATATCACTTAATTTCCTATTAGG
TTTGCTTTATGGATATGTGATGGGCTTCCCCTTATTAGAGACGTTAATTATTGCTGGAATCATTACAATTTCATCAAGTG
CAATTGTTGCAAAAGTCATTGTTGATTTAAGAAGATCTGGTAATAAAGAGACGGAGCTGATTTTAGGAATCATTATGTTT
GATGATATCTTTTTAGCGGTATATTTATCAGTCGTTTCAGGATTAGTACTCGGAGGGGCAACGTCATTTGCAGGTGCTCT
TACGTCGGTGTTAATTGCAGTAGGGTATATGCTCCTATTTTTTGTAATCGCTAGAAAAGCTACGCCGTTTTTAAATAAAG
TATTAGATATTTCGTCTAACGAAATTTTCATAATCGTAATATTTGCTATTTTATTCTTCGTAGCAGGATTTTCCGAAACA
ATTCATGTTGCGGAAGCGATTGGAGCTTTATTATTAGGACTCGTCTTTTCTGAAACGGAGCATAGCGATCGAATTGAAAA
GCTCGTCGTCCCATTCCGTGATTTCTTTGGAGCCATATTCTTTTTCAGCTTCGGTTTAAGTATAGATCCGTTTTCGCTTG
GAGGCGCAGTATGGTTGGCATTAGGAGCAGTTTTCATTACTCTCATCGGTAATTTTACTGCTGGAATGATTGCGGGGCGT
AAAGCCGGGTTATCCCATAAGGCTTCTACGAATATAGGCTTAACACTCGTATCACGCGGAGAGTTCTCCATTATTGTAGC
AAATATCGGGATTGCGGGTGGCTTAATGGCAGCGATTAAACCGTTCTCTGCACTGTACGTTTTAATATTAGCATCGTTAG
GACCGTTATTAACGAAAGAGTCTGGGAGAATATACTCTCTACTAGATAAGTTGTTTAAATGGAGTGCTAAAGAACGTGCA
AAGCGAGAAAAAGAAGTTGGGTAA

Upstream 100 bases:

>100_bases
TATTATTGAAGCTGGCGATATGCTTGTGTTATCGGGCGCGAGACATGAAGTGAAAAGAATTATTAATGAATTGCTTTCAG
CAGGAGGTGATTCATAATCG

Downstream 100 bases:

>100_bases
TATATAAAGAGGCTGCATGAACTTCATGCAGCCTCTTTATATATTGTTATTGTTGTCGTTTTTTGTCGGTAAGTCGATAT
ATTCTAATAATCGCTGATAT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFKWSAKERA
KREKEVG

Sequences:

>Translated_407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFKWSAKERA
KREKEVG
>Mature_407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKLFKWSAKERA
KREKEVG

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=279, Percent_Identity=28.673835125448, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1786685, Length=351, Percent_Identity=27.9202279202279, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786232, Length=262, Percent_Identity=25.9541984732824, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43589; Mature: 43589

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVFITLIGNFTAGMIAGRKAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKLFKWSAKERAKREKEVG
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFAGALTSVLIAVGYMLLFFVIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVFITLIGNFTAGMIAGRKAGLSHKASTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKLFKWSAKERAKREKEVG
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]