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The map label for this gene is sdhA

Identifier: 49478676

GI number: 49478676

Start: 4313788

End: 4315581

Strand: Reverse

Name: sdhA

Synonym: BT9727_4252

Alternate gene names: 49478676

Gene position: 4315581-4313788 (Counterclockwise)

Preceding gene: 49480679

Following gene: 49480678

Centisome position: 82.39

GC content: 39.74

Gene sequence:

>1794_bases
ATGAAAGGGAAACTTATAGTAGTCGGCGGTGGCTTGGCTGGCTTAATGGCAACGATTAAAGCGGCGGAAGCAGGAGTAAA
TGTTGAACTGTTCTCTTTAGTACCAGTAAAACGTTCGCATTCTGTATGTGCCCAAGGTGGAATTAACGGTGCCGTGAATA
CGAAAGGTGAAGGGGATTCTCCATGGATCCACTTTGACGATACAATTTATGGTGGGGACTTCTTAGCGAACCAACCACCA
GTTAAAGCAATGTGTGAAGCAGCACCTGGTATCATTCATTTAATGGACCGTATGGGTGTTATGTTCAACCGTACGGAAGA
AGGACTTCTTGATTTCCGTCGTTTTGGTGGAACGCAACATCACCGTACAGCATTTGCTGGTGCAACAACTGGACAGCAAT
TACTATACGCATTAGATGAGCAAGTACGTCGTCATGAAGTAGCAGGACTTGTAACGAAATATGAAGGTTGGGATTTCTTA
CGAGCTGTTGTTGATGACGAAGGTGTGTGCCGAGGAATCGTTGCACAAGACTTACAAACAATGGAGATTAAAAGTTTCGG
AGCTGATGCCGTGATTATGGCAACAGGGGGCCCTGGTATCATCTTCGGAAAATCAACTAACTCTATTATTAATACAGGTA
CAGCAGCTTCTGCTGTATATCAACAAGGCGCATATTATGCAAACGGTGAGTTCATTCAAATTCACCCAACGGCAATTCCT
GGAGACGATAAATTACGTCTTATGAGTGAATCTGCACGTGGTGAAGGTGGACGTGTTTGGACATATAAAGATGGTAAACC
ATGGTACTTCTTAGAAGAAAAATATCCGGCTTACGGAAATCTTGTACCTCGTGATATCGCAACGCGTGAAATCTTTGATG
TTTGCGTAGAGCAAAAACTAGGTATTAACGGTGAAAATATGGTTTACTTAGATCTTTCTCATAAAGATCCGAAAGAACTA
GATATTAAACTTGGTGGAATTATTGAAATCTATGAGAAATTTACAGGTGATGATCCTCGTAAACTACCAATGAAAATCTT
CCCAGCTGTTCACTATTCAATGGGCGGACTATGGGTTGATTATAAACAGATGACAAATATTCCAGGTTTATTTGCAGCAG
GTGAGTGTGATTATTCTATGCACGGTGGTAACCGTCTTGGTGCGAACTCACTATTATCAGCAATTTACGGTGGTATGGTA
GCAGGACCAAATGCAATTGAATATATGAAAGGTCTTTCTAAATCATCAGATGCTGTTTCATCTACTGTGTATGAACAAAA
TGAATTAATCGAAACAGAGAAATTTAACAATATTTTAACGCTCGATGGTAACGAAAATGCGTATGTTCTTCATAAAGAGC
TTGGAGAATGGATGACAGATAATGTTACAGTAGTTCGTGAAAATAAAAAATTATTAGAAACAGATGCAAAAATTGAAGAG
TTAATGGCTCGTTATAAACGTATTAACATTAACGATACAGCAAGATGGAGTAACCAAGGTGCTTCATTTACACGCCAACT
TGCAAATATGTTTGAGCTAGCACGTGTTATTACAATTGGTGCATATAACCGTAATGAGAGCCGTGGAGCGCATTACAAAC
CTGAATTCCCAAATCGTGATGATGCAAACTTCTTAAAAACTACGATGGCAAAATTTGAAGGAGAAGGAAATGCACCAGCA
TTCCATTACGAAGATGTGGATATTTCATTAATTAAACCACGTAAACGTGATTATTCTTCAAAACACGATGTAGCTGCTAA
GAGTGAAGAGAAGGGGGATAAACAACATGTCTGA

Upstream 100 bases:

>100_bases
GTAACATTAGCTATTTTCTTAGGTCTATCTTATGTAGGTGTGAGTGCATTATTAGCGTTCATCGATCCACAGCTAGCAAA
CCAGTAAGGAGTGGGAGAGC

Downstream 100 bases:

>100_bases
GAAAACAATCCGCCTCATCATTACGAGACAAGACGGACCAGACGCGCAAGCGTTTGATCAAGAGTTTGAAATTCCTTATC
GTCCAAATATGAATATTATT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVVDDEGVCRGIVAQDLQTMEIKSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPNAIEYMKGLSKSSDAVSSTVYEQNELIETEKFNNILTLDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEE
LMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRDDANFLKTTMAKFEGEGNAPA
FHYEDVDISLIKPRKRDYSSKHDVAAKSEEKGDKQHV

Sequences:

>Translated_597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVVDDEGVCRGIVAQDLQTMEIKSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPNAIEYMKGLSKSSDAVSSTVYEQNELIETEKFNNILTLDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEE
LMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRDDANFLKTTMAKFEGEGNAPA
FHYEDVDISLIKPRKRDYSSKHDVAAKSEEKGDKQHV
>Mature_597_residues
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQPP
VKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQHHRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFL
RAVVDDEGVCRGIVAQDLQTMEIKSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKLGINGENMVYLDLSHKDPKEL
DIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVDYKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPNAIEYMKGLSKSSDAVSSTVYEQNELIETEKFNNILTLDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEE
LMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRDDANFLKTTMAKFEGEGNAPA
FHYEDVDISLIKPRKRDYSSKHDVAAKSEEKGDKQHV

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=539, Percent_Identity=31.5398886827458, Blast_Score=224, Evalue=3e-58,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=32.6315789473684, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=32.5581395348837, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI1788928, Length=553, Percent_Identity=27.124773960217, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=30.6839186691312, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=546, Percent_Identity=30.952380952381, Blast_Score=219, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322701, Length=550, Percent_Identity=32.3636363636364, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=29.9295774647887, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI17137288, Length=539, Percent_Identity=31.5398886827458, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24655642, Length=539, Percent_Identity=31.5398886827458, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24655647, Length=539, Percent_Identity=31.5398886827458, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24663005, Length=547, Percent_Identity=31.4442413162706, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65923; Mature: 65923

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQH
CEEEECCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHCCCCHHHHHHHHHCCCCCH
HRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVVDDEGVCRGIVAQDLQT
HCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHHHHHHCHHH
MEIKSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIP
HHHHHCCCCEEEEEECCCEEEEECCCCCEEECCCHHHHHHHCCCEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVD
CCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEE
YKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAIEYMKGLSKSSDAVS
HHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHH
STVYEQNELIETEKFNNILTLDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEE
HHHHHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
LMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRD
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCC
DANFLKTTMAKFEGEGNAPAFHYEDVDISLIKPRKRDYSSKHDVAAKSEEKGDKQHV
CHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKGKLIVVGGGLAGLMATIKAAEAGVNVELFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQPPVKAMCEAAPGIIHLMDRMGVMFNRTEEGLLDFRRFGGTQH
CEEEECCEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHCCCCHHHHHHHHHCCCCCH
HRTAFAGATTGQQLLYALDEQVRRHEVAGLVTKYEGWDFLRAVVDDEGVCRGIVAQDLQT
HCEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHCCCCHHHHHHHHCHHH
MEIKSFGADAVIMATGGPGIIFGKSTNSIINTGTAASAVYQQGAYYANGEFIQIHPTAIP
HHHHHCCCCEEEEEECCCEEEEECCCCCEEECCCHHHHHHHCCCEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVEQKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GINGENMVYLDLSHKDPKELDIKLGGIIEIYEKFTGDDPRKLPMKIFPAVHYSMGGLWVD
CCCCCCEEEEEECCCCCCCEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEE
YKQMTNIPGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAIEYMKGLSKSSDAVS
HHHHCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHH
STVYEQNELIETEKFNNILTLDGNENAYVLHKELGEWMTDNVTVVRENKKLLETDAKIEE
HHHHHHHHHHHHHHCCCEEEEECCCCEEEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHH
LMARYKRININDTARWSNQGASFTRQLANMFELARVITIGAYNRNESRGAHYKPEFPNRD
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCC
DANFLKTTMAKFEGEGNAPAFHYEDVDISLIKPRKRDYSSKHDVAAKSEEKGDKQHV
CHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]