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The map label for this gene is yqgN [H]

Identifier: 49478598

GI number: 49478598

Start: 4069707

End: 4070285

Strand: Reverse

Name: yqgN [H]

Synonym: BT9727_4006

Alternate gene names: 49478598

Gene position: 4070285-4069707 (Counterclockwise)

Preceding gene: 49481569

Following gene: 49478835

Centisome position: 77.71

GC content: 35.41

Gene sequence:

>579_bases
GTGAGAGAAGAGAAACTACGTTTACGTAAACAAATAATAGAGCACATGAATTCTTTATCAAAAGAACGGTATATAACTTT
ATCAGAGCAAATAGCATTTTCGTTGTATGAGCAAAAAGAGTGGGCTGAAGCTAAAACAATTGGAATCACTCTCTCGATGG
AAAATGAAGTGAATACATATCCTATTATCGAAAAAGCTTGGGAAGAAGGAAAGAGAGTTGTTGTTCCGAAGTGTAATAAA
GAAACAAGAACGATGTCCTTTAGGCAAATTAGTAATTTTGATCAATTAGAAACAGTGTATATGAATTTACGTGAGCCAAT
TCCAGCACTTACGGAAGAAGCGAATGCAGATGAAATTGACCTTCAAATCGTACCAGGCGTAGCTTATACAGAGCGAGGAG
AACGGATTGGATATGGCGGTGGCTATTATGATCGTTATCTCGTGCATTATAAAGGGAAAACGCTATCATTAGCTTATAGT
TTTCAAATGGTAGAACATATTCCAGTAGAGCCGTTTGATAAAAATGTAGAAAAAATTATTACAGAAAAAGGAACAATGGT
TAAAAATGGGCTTGTATAG

Upstream 100 bases:

>100_bases
TAGGAATATTTTCCTACTGTTTCTTTTTTTATTCGATTCCTCTCTTAAAAATGATACACTATCATCGTAGAGCAAAGTAT
CACTGTGAGGGGGAAAATGT

Downstream 100 bases:

>100_bases
ACAAATAAAAATTGACGAGACTTTTTCTTCTTGATTATAATAAAATATGTGAACGTTTTCTTATTATAATTTTTTATAGT
AAGTGAGCATAGAGGGTGAT

Product: 5-formyltetrahydrofolate cyclo-ligase

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MREEKLRLRKQIIEHMNSLSKERYITLSEQIAFSLYEQKEWAEAKTIGITLSMENEVNTYPIIEKAWEEGKRVVVPKCNK
ETRTMSFRQISNFDQLETVYMNLREPIPALTEEANADEIDLQIVPGVAYTERGERIGYGGGYYDRYLVHYKGKTLSLAYS
FQMVEHIPVEPFDKNVEKIITEKGTMVKNGLV

Sequences:

>Translated_192_residues
MREEKLRLRKQIIEHMNSLSKERYITLSEQIAFSLYEQKEWAEAKTIGITLSMENEVNTYPIIEKAWEEGKRVVVPKCNK
ETRTMSFRQISNFDQLETVYMNLREPIPALTEEANADEIDLQIVPGVAYTERGERIGYGGGYYDRYLVHYKGKTLSLAYS
FQMVEHIPVEPFDKNVEKIITEKGTMVKNGLV
>Mature_192_residues
MREEKLRLRKQIIEHMNSLSKERYITLSEQIAFSLYEQKEWAEAKTIGITLSMENEVNTYPIIEKAWEEGKRVVVPKCNK
ETRTMSFRQISNFDQLETVYMNLREPIPALTEEANADEIDLQIVPGVAYTERGERIGYGGGYYDRYLVHYKGKTLSLAYS
FQMVEHIPVEPFDKNVEKIITEKGTMVKNGLV

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=192, Percent_Identity=27.6041666666667, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1789278, Length=168, Percent_Identity=30.3571428571429, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17510857, Length=199, Percent_Identity=29.6482412060301, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321031, Length=204, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077430, Length=191, Percent_Identity=28.2722513089005, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 22350; Mature: 22350

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREEKLRLRKQIIEHMNSLSKERYITLSEQIAFSLYEQKEWAEAKTIGITLSMENEVNTY
CCHHHHHHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCC
PIIEKAWEEGKRVVVPKCNKETRTMSFRQISNFDQLETVYMNLREPIPALTEEANADEID
CHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCCCEEE
LQIVPGVAYTERGERIGYGGGYYDRYLVHYKGKTLSLAYSFQMVEHIPVEPFDKNVEKII
EEEECCCEECCCCCEECCCCCHHHEEEEEECCCEEEEEEEEEHHHHCCCCCCCCCHHHHH
TEKGTMVKNGLV
HCCCCEECCCCC
>Mature Secondary Structure
MREEKLRLRKQIIEHMNSLSKERYITLSEQIAFSLYEQKEWAEAKTIGITLSMENEVNTY
CCHHHHHHHHHHHHHHHHHCHHHEEEEHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCC
PIIEKAWEEGKRVVVPKCNKETRTMSFRQISNFDQLETVYMNLREPIPALTEEANADEID
CHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCCCEEE
LQIVPGVAYTERGERIGYGGGYYDRYLVHYKGKTLSLAYSFQMVEHIPVEPFDKNVEKII
EEEECCCEECCCCCEECCCCCHHHEEEEEECCCEEEEEEEEEHHHHCCCCCCCCCHHHHH
TEKGTMVKNGLV
HCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]