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The map label for this gene is gcvPA [H]

Identifier: 49478587

GI number: 49478587

Start: 4037902

End: 4039245

Strand: Reverse

Name: gcvPA [H]

Synonym: BT9727_3970

Alternate gene names: 49478587

Gene position: 4039245-4037902 (Counterclockwise)

Preceding gene: 49478588

Following gene: 49480639

Centisome position: 77.12

GC content: 38.32

Gene sequence:

>1344_bases
ATGTTGCATCGTTATCTTCCAATGACAGAAGAAGACAAAAAAGAAATGTTACAAACGATCGGCGTTCAAACGATCGATGA
GTTATTCTCTGATATTCCAGAGAGTGTTCGTTTTAAAGGGGATTTAAAAATTAAAGAAGCAAAATCAGAGCCAGAGCTTT
TAAAAGAGTTATCTCAAATAGCTAGTAAAAATGCGAACTTAAAAGAATACGCTTCTTTCTTAGGAGCTGGTGTATACGAT
CATTACGCTCCAGTAATTGTAGATCATGTTATCTCTCGCTCAGAATTTTATACAGCTTACACGCCATACCAACCAGAAAT
TTCACAAGGGGAATTACAAGCAATCTTTGAATTCCAAACGATGATTTGTGAATTAACAGGAATGGATGTAGCAAACTCTT
CTATGTACGACGGTGGTACAGCTTTAGCTGAAGCGGCAATGCTAGCGGCTGGCCATACTCGTAAAAAGAAAATTCTTGTA
TCTAGTGCAGTGCACCCAGAATCAAGAGCAGTACTTGAAACATATGCAAAAGGTCAACATCTTGAAGTTGTTGAAATTAA
TCATAAAGATGGTGTAACAGATTTAGACGTATTACAAAGTGAAGTAGATGATACTGTTGCTTGTGTAATCGTTCAATATC
CAAACTTCTTCGGACAAGTTGAAAAATTAGCTGATATTGAAAAAATCGTTCATCAACAAAAATCATTATTTATCGTTTCT
TCAAATCCATTATCATTAGGCGCATTAACACCACCAGGAAAATTTGGTGCTGATATTGTAATCGGTGATGCACAGCCATT
TGGTATTCCAACGCAGTTTGGTGGACCGCACTGTGGTTACTTTGCAACAACGAAAGCATTTATGCGTAAAATTCCAGGAC
GTCTTGTTGGACAAACTGTAGATTCAGATGGGAAACGTGGGTTTGTATTAACGTTACAGGCACGTGAACAGCATATCCGC
CGTGATAAAGCGACATCTAACATTTGTTCAAACCAAGCGTTAAATGCATTAGCAGCTTCTGTTGCAATGACGGCACTTGG
TAAACAAGGTGTGAAAGAAATGGCACGTCAAAACATTTCTAAAGCGCAATACGCAAAACGTCAATTCGAAGCGAAAGGCT
TCACTGTAACATTTGCTGGTCCATTCTTCAATGAGTTCGTTGTAGATTGTAAGCGTCCAGTGAAAGAAGTAAACGATGCA
TTATTACAAAAGAATATTATCGGCGGTTACGATCTAGGCCGTGATTATAAAGAGCATGAGAACCATATGCTTGTAGCAGT
AACTGAGCTTCGTACAAAAGAGGAAATTGACACACTTGTAAACGAAATGGGGGCTATCCAATGA

Upstream 100 bases:

>100_bases
CAGAAGTAGAAATTGAAATTCGTAATAAACGCGTCAAAGCAGTAGTTGTTCCAACACCATTTTATAAACGTTCAAAGTAA
CGGGGAGAGGGGTAGATTTC

Downstream 100 bases:

>100_bases
AGAACCAAGACCAAGCACTTATCTTTGAAGTGAGTAAAGAAGGACGCATAGGATATAGCTTACCAAAATTAGATGTAGAA
GAAGTGAAACTAGAAGATGT

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQIASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ

Sequences:

>Translated_447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQIASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ
>Mature_447_residues
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQIASKNANLKEYASFLGAGVYD
HYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQTMICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILV
SSAVHPESRAVLETYAKGQHLEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTVDSDGKRGFVLTLQAREQHIR
RDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNISKAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDA
LLQKNIIGGYDLGRDYKEHENHMLVAVTELRTKEEIDTLVNEMGAIQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=408, Percent_Identity=38.7254901960784, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1789269, Length=394, Percent_Identity=33.502538071066, Blast_Score=203, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17535605, Length=360, Percent_Identity=40, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323843, Length=368, Percent_Identity=40.4891304347826, Blast_Score=263, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24645648, Length=358, Percent_Identity=39.1061452513966, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49404; Mature: 49404

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ASKNANLKEYASFLGAGVYDHYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSSAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHCCCCC
LEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
EEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCCEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DSDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDALLQKNIIGGYDLGRDYKEHE
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NHMLVAVTELRTKEEIDTLVNEMGAIQ
CCEEEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLHRYLPMTEEDKKEMLQTIGVQTIDELFSDIPESVRFKGDLKIKEAKSEPELLKELSQI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHEECCCEEEECCCCCHHHHHHHHHH
ASKNANLKEYASFLGAGVYDHYAPVIVDHVISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
MICELTGMDVANSSMYDGGTALAEAAMLAAGHTRKKKILVSSAVHPESRAVLETYAKGQH
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHEEEECCCCCCCHHHHHHHHCCCCC
LEVVEINHKDGVTDLDVLQSEVDDTVACVIVQYPNFFGQVEKLADIEKIVHQQKSLFIVS
EEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEE
SNPLSLGALTPPGKFGADIVIGDAQPFGIPTQFGGPHCGYFATTKAFMRKIPGRLVGQTV
CCCCEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCC
DSDGKRGFVLTLQAREQHIRRDKATSNICSNQALNALAASVAMTALGKQGVKEMARQNIS
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAQYAKRQFEAKGFTVTFAGPFFNEFVVDCKRPVKEVNDALLQKNIIGGYDLGRDYKEHE
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCC
NHMLVAVTELRTKEEIDTLVNEMGAIQ
CCEEEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA