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The map label for this gene is mtnA

Identifier: 49478500

GI number: 49478500

Start: 3867752

End: 3868807

Strand: Reverse

Name: mtnA

Synonym: BT9727_3774

Alternate gene names: 49478500

Gene position: 3868807-3867752 (Counterclockwise)

Preceding gene: 49479358

Following gene: 49479357

Centisome position: 73.86

GC content: 36.74

Gene sequence:

>1056_bases
ATGAGTACAGTTGTTACGATTCCGAGGTCTGTCAGTTGGAAAGGTGATGCCATTGCAGTATTAAATCAAACAAAGTTGCC
GCATAGCACAGAATACAAAACATTAACGACGATTGAAGAGGTATGGAAAAGTATTGTCATGCTAGAAGTAAGAGGAGCAC
CTGCAATTGGAATTGTAGCTGCATTTGGCTTGGCGCTTGCATCAAAAAAATATACTACTTTACATATTGAAGAATTTCAA
AAGAAGTTTAATAGAGATTGTAATTATTTAGGAACTTCACGCCCAACAGCAGTCAATTTATTTTGGGCAATCGATCGTAT
GAGAGAATCTATTCAAGAAATTACTACAATAAAAGAAGCGCAAAAAATATTAGAAGAAGAAGCGCTTCGTATTCAGCAAG
AAGATGAAGCGGTATGCCGGAGTATTGGAGAACATGCATTAACATGCTTTAAAGACGGTGATAACATTTTAACAATTTGT
AACGCTGGCAGTATTGCAACTGCTAGATATGGTACTGCATTAGCACCGTTTTATATTGGGAAAGAAAAAGGTGTACGGTT
ACATGCGTATGCGTGTGAAACGAGACCGGTTTTACAAGGCGGACGTTTAACGACCTGGGAATTAAAACAGGCAGGTATTG
ATGTAACACTTATTACAGATAATACGGCAGCTCATGCTATTCAAACGAAAGAAATCAACGCAATTATTGTAGGAGCGGAC
CGAATTGTCGCAAATGGGGATACAGCAAATAAAATCGGAACGATGAATTTAGCTATATTAGCAAAGTATTTCGATATCCC
GTTCTACGTTGCAGCTCCACTATCGACATTTGATATTACGAAACAAACAGGTGCAGAAATTGTTATTGAAGAAAGAGATG
AAACAGAAGTTACGAAAATTTTTGGGAAACAGGTGGCACCAGTTGGAACTACTGTTTATAATCCTGCATTTGATGTAACA
CCAAATAAATTAATTACAGGTATTATTACTGAGAAAGGTATTATATGCGGAGATTATAAGCGAGAAATTGTATCATTGTT
TGAAAAAACAAGCTAA

Upstream 100 bases:

>100_bases
TATCCTTAGGGAAAGAACTAATAAAATATGAGTCTAAGAACGCCGATATTCAACTGTTCCGAACATTATTTCAACAGACA
GTTTCTGGAGGGATAAAAGC

Downstream 100 bases:

>100_bases
TACATAATAGCTTGTTTTTTTATGCCTAAATGTGTTCTTTTTTCTTATTTATATAATGAAAGGAGGAGAAAAAGATGGAA
GAGTGGATCAAGATGATAGG

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi 2; MTR-1-P isomerase 2; S-methyl-5-thioribose-1-phosphate isomerase 2 [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSTVVTIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEINAIIVGAD
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVT
PNKLITGIITEKGIICGDYKREIVSLFEKTS

Sequences:

>Translated_351_residues
MSTVVTIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQ
KKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTIC
NAGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEINAIIVGAD
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVT
PNKLITGIITEKGIICGDYKREIVSLFEKTS
>Mature_350_residues
STVVTIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVAAFGLALASKKYTTLHIEEFQK
KFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEAQKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICN
AGSIATARYGTALAPFYIGKEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEINAIIVGADR
IVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKIFGKQVAPVGTTVYNPAFDVTP
NKLITGIITEKGIICGDYKREIVSLFEKTS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=350, Percent_Identity=39.7142857142857, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI23943880, Length=336, Percent_Identity=36.9047619047619, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI78000156, Length=346, Percent_Identity=25.1445086705202, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI78000158, Length=346, Percent_Identity=25.1445086705202, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI187607323, Length=346, Percent_Identity=25.1445086705202, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=332, Percent_Identity=35.2409638554217, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17557123, Length=163, Percent_Identity=29.4478527607362, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=397, Percent_Identity=35.264483627204, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI21357667, Length=369, Percent_Identity=37.1273712737127, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24651647, Length=369, Percent_Identity=37.1273712737127, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 38623; Mature: 38492

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVVTIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVA
CCCEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHH
AFGLALASKKYTTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEA
HHHHHHHCCCEEEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCEEEECCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEINAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEHHHCCEEEEEEECCCHHHEEEECCCCEEEEECC
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKI
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHH
FGKQVAPVGTTVYNPAFDVTPNKLITGIITEKGIICGDYKREIVSLFEKTS
HCCCCCCCCCEEECCCCCCCCHHHEEEEECCCCEEECHHHHHHHHHHHCCC
>Mature Secondary Structure 
STVVTIPRSVSWKGDAIAVLNQTKLPHSTEYKTLTTIEEVWKSIVMLEVRGAPAIGIVA
CCEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCHHHHHH
AFGLALASKKYTTLHIEEFQKKFNRDCNYLGTSRPTAVNLFWAIDRMRESIQEITTIKEA
HHHHHHHCCCEEEEEHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
QKILEEEALRIQQEDEAVCRSIGEHALTCFKDGDNILTICNAGSIATARYGTALAPFYIG
HHHHHHHHHHCCCHHHHHHHHHHHHHEEEEECCCCEEEEECCCCEEEECCCCEECCEEEC
KEKGVRLHAYACETRPVLQGGRLTTWELKQAGIDVTLITDNTAAHAIQTKEINAIIVGAD
CCCCEEEEEEEECCCCCCCCCCEEEEEHHHCCEEEEEEECCCHHHEEEECCCCEEEEECC
RIVANGDTANKIGTMNLAILAKYFDIPFYVAAPLSTFDITKQTGAEIVIEERDETEVTKI
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCEECCCCCCCEEEEECCCCHHHHHH
FGKQVAPVGTTVYNPAFDVTPNKLITGIITEKGIICGDYKREIVSLFEKTS
HCCCCCCCCCEEECCCCCCCCHHHEEEEECCCCEEECHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721630 [H]