Click here to switch to the map view.

The map label for this gene is sdaC

Identifier: 49478476

GI number: 49478476

Start: 3249868

End: 3251187

Strand: Reverse

Name: sdaC

Synonym: BT9727_3177

Alternate gene names: 49478476

Gene position: 3251187-3249868 (Counterclockwise)

Preceding gene: 49478210

Following gene: 49478209

Centisome position: 62.07

GC content: 35.45

Gene sequence:

>1320_bases
ATGAACGGGAATACTGCAAAGAAAATAGAAGTTCAAGCTGAAAATAACGCACTAAAAAATGAGCAATATGCAGATCCGAA
AAAGTGGCATAAGCAGGATACTACATGGGCACTCAGTCTATTTGGAACTGCAATTGGAGCAGGGGTGCTCTTTTTACCGA
TTAATGCAGGTTCAGGTGGTTTATTATCATTACTACTAATTACATTGCTTGCATATCCAGTTATGTATTACTCACATAGG
GCACTTGCGAAAATGATATACGCTTCTAATTCTGCTGATGAGGGGATCACAGGTACAATTAGAGAGTATTTCGGAAATAA
AGCGAGTATCATTTTTAACATCGTATATTTCGGTTCAATTTATACAATCGTACTAATGTATTCGGTTGCGCTTACAAATA
CTGCAAGTAGTTTTATCGTGCATCAATTGAACATGCCAGAACCTCCAAGGGCTATTTTATCACTTGTATTAGTTCTTGGT
CTTATCGCTATACTGAACTTTGGTCAAGATATTACTGTAAAGGTAATGAGTATGCTAGTGTATCCTTTCATAGCTTCTCT
ACTGTTTATTGCAATATCTTTAATTCCACAGTGGAATACGTCAATGCTTAGCTTTTCAGCTGTTTCTACTGCTTCAACAG
GAACAGGCTATTTTGGAACGATATTGATGATTTTACCAATCATCGTATTCTCATTTAATCATTCACCTATGATTTCATCA
TTTGTTGTGAAACAGAGAGCTACGTATGGAATAGAAGCTACTGATGCGAAATGTGCGCAAATACAAAAAGTTTGTTATAT
TATGACATTCGTTGTAGTTATGTTCTTCGTTTGGAGTAGCGCACTGAGCCTGACTCCAGATGATTTAAAAATGGCAAAAG
AGCAAAACTTATCAATTCTTTCTTACCTTGCTAATGAGCTTAATTCACCTGTAATCACGATTGCAGCTCCAATCATTGCT
TTTGTGGCTATTACAAAGTCTTTCCTTGGCCATTATATCGGAGCGTTTGAAGTAATGCGTGACATGATTATTAAGTTTGG
TAAATCACGTGGAAAAGTAATCGAAGAAAAAACAATTAAGACAATCGTCCTTACTTTTGTTGTATTATCATGCTGGTTTG
TTGCTTATACAAATCCAAGTATTCTTGGACTTATTGATTCTCTAAGTGGTCCATTAGTTGCGGCTATCTTATGTCTATTA
CCGATGTATGCGATTCAAAAAGTCCCAGTATTAGCTAAGTATAAAGGGAAAATGAGTAACGTATTTGTTATTATTGTAGG
TGTGCTTACTGTTTTAGCAAGTATTAAATCATTATTCTAA

Upstream 100 bases:

>100_bases
CAATGTGGGGCAACTTGTAAGGAATTCATTTTCCGAAAAAAGGAAAAATTCGATAGCTATTAAGAGAGATGCAGGAATAG
ATACAAGGGGGAGTTATTAT

Downstream 100 bases:

>100_bases
TTCACGATTGTTAGTTCTAGTACAAAATAAAATAGAACGATTTTGGGACAGGCTTCTCCGTTTGGAGAGTTTGTCCCTTT
TTTAATGAGTGATAAAAGCT

Product: serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTILMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFVVVMFFVWSSALSLTPDDLKMAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKVIEEKTIKTIVLTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Sequences:

>Translated_439_residues
MNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTILMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFVVVMFFVWSSALSLTPDDLKMAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKVIEEKTIKTIVLTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF
>Mature_439_residues
MNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGGLLSLLLITLLAYPVMYYSHR
ALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSIYTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLG
LIAILNFGQDITVKVMSMLVYPFIASLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTILMILPIIVFSFNHSPMISS
FVVKQRATYGIEATDAKCAQIQKVCYIMTFVVVMFFVWSSALSLTPDDLKMAKEQNLSILSYLANELNSPVITIAAPIIA
FVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKVIEEKTIKTIVLTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLL
PMYAIQKVPVLAKYKGKMSNVFVIIVGVLTVLASIKSLF

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=50.5827505827506, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1789504, Length=428, Percent_Identity=44.392523364486, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1789211, Length=409, Percent_Identity=35.9413202933985, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI145693183, Length=428, Percent_Identity=25.4672897196262, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789961, Length=413, Percent_Identity=23.9709443099274, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48003; Mature: 48003

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLV
HHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIASLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTILMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
FVVKQRATYGIEATDAKCAQIQKVCYIMTFVVVMFFVWSSALSLTPDDLKMAKEQNLSIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKVIEEKTIK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TIVLTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSN
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
VFVIIVGVLTVLASIKSLF
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGNTAKKIEVQAENNALKNEQYADPKKWHKQDTTWALSLFGTAIGAGVLFLPINAGSGG
CCCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEECCCCCH
LLSLLLITLLAYPVMYYSHRALAKMIYASNSADEGITGTIREYFGNKASIIFNIVYFGSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
YTIVLMYSVALTNTASSFIVHQLNMPEPPRAILSLVLVLGLIAILNFGQDITVKVMSMLV
HHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
YPFIASLLFIAISLIPQWNTSMLSFSAVSTASTGTGYFGTILMILPIIVFSFNHSPMISS
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
FVVKQRATYGIEATDAKCAQIQKVCYIMTFVVVMFFVWSSALSLTPDDLKMAKEQNLSIL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHH
SYLANELNSPVITIAAPIIAFVAITKSFLGHYIGAFEVMRDMIIKFGKSRGKVIEEKTIK
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
TIVLTFVVLSCWFVAYTNPSILGLIDSLSGPLVAAILCLLPMYAIQKVPVLAKYKGKMSN
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
VFVIIVGVLTVLASIKSLF
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]