Click here to switch to the map view.

The map label for this gene is sqhC

Identifier: 49478274

GI number: 49478274

Start: 3389373

End: 3391226

Strand: Reverse

Name: sqhC

Synonym: BT9727_3315

Alternate gene names: 49478274

Gene position: 3391226-3389373 (Counterclockwise)

Preceding gene: 49479475

Following gene: 49478973

Centisome position: 64.75

GC content: 37.27

Gene sequence:

>1854_bases
TTGTTATTATACGAAAAAGCGCATGAAGAAATAGTGAGAAGAGCAACAGCACTTCAAACAATGCAATGGCAAGATGGTAC
GTGGCGATTTTGTTTTGAAGGAGCTCCATTAACAGATTGCCATATGATTTTTTTATTAAAATTATTAGGTAGAGATAAAG
AGATAGAACCGTTCGTAGAAAGAGTAGCATCACTCCAAACAAATGAAGGAACATGGAAATTGTATGAAGATGAAGTAGGA
GGTAATTTATCAGCTACAATTCAATCTTATGCCGCCTTACTTGCATCGAAAAAATATACAAAAGAAGATGCGAATATGAA
ACGAGCGGAAAATTTTATTCAGGAACGCGGTGGCGTGGCGCGTGCTCATTTTATGACGAAGTTTTTATTAGCAATTCATG
GAGAATATGAATATCCTTCACTCTTTCATTTACCAACACCAATCATGTTTCTACAGAATGATTCCCCCTTTAGTATATTT
GAATTAAGTAGCTCAGCACGTATTCATTTAATTCCGATGATGCTATGTTTAAATAAAAGATTTCGAGTAGGGAAAAAGTT
ATTACCAAATTTAAATCACATTGCGGGCGGAGGCGGAGAATGGTTTCGGGAGGATCGGTCTCCAGTTTTTCAAACGTTAT
TAAGTGATGTAAAACAAATTATATCGTATCCACTTTCGTTACATCATAAAGGATATGAGGAAATAGAACGTTTTATGAAA
GAGCGTATTGATGAAAATGGAACGTTATATAGTTACGCAACTGCCTCGTTTTATATGATTTATGCTTTACTTGCGTTAGG
GCATTCTCTTCAATCATCAATGATTCAAAAGGCTATAGCTGGGATAACATCTTATATATGGAAGATGGAAAGAGGGAATC
ATTTGCAAAACTCTCCTTCAACCGTGTGGGATACAGCTTTATTAAGCTATGCGTTACAAGAGGCTCAAGTTTCAAAGGAT
AATAAGATGATTCAAAATGCAACAGCGTATTTATTAAAAAAACAGCATACAAAAAAAGCTGATTGGAGCGTACATGCTCC
GGCGCTTACTCCTGGCGGTTGGGGTTTTTCGGATGTGAATACGACAATTCCAGATATAGATGATACAACAGCTGTGCTAA
GGGCATTGGCACGAAGTAGAGGAAACAAAAATATAGATAATGCTTGGAAGAAAGGGGGCAATTGGATTAAAGGATTACAA
AACAATGATGGTGGCTGGGGAGCATTTGAAAAAGGTGTGACGAGCAAATTATTAGCAAAATTACCAATCGAAAACGCAAG
TGATATGATTACAGATCCTTCTACGCCAGATATTACGGGGAGAGTGTTAGAGTTTTTCGGGACATATGCACAAAACGAAT
TGCCTGAGAAACAGATACAAAGGGCAATAAATTGGTTAATGAATGTACAAGAGGAAAATGGATCATGGTATGGGAAATGG
GGGATTTGTTATATATATGGTACGTGGGCTGTTATGACTGGTTTACGGTCACTCGGAATTCCGTCTAGCAATCCTTCATT
GAAACGAGCAGCTTCATGGCTTGAACATATACAGCATGAAGATGGTGGTTGGGGAGAATCATGCCACAGTAGTGTGGAGA
AAAGGTTCGTTACTTTACCATTTAGTACACCATCCCAAACTGCATGGGCGTTAGATGCTCTCATTTCTTACTATGATACA
GAAACGCCAGCTATTCGAAAAGGTGTTTCATATTTGCTTTCGAATCCTTATGTGAATGAAAGATATCCTACTGGAACAGG
TTTACCAGGTGCGTTTTATATTAGGTATCATAGCTATGCCCATATATATCCACTACTTACTTTAGCACATTATTTAAAAA
AATATAGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAACATTTTATATGTTCTGCTTTTCTTTGTATTCATACATATTCAGCTACCTTCTTGAATATCGTTATACGGATTT
CGAAAGGGTGGGTGAGTAAC

Downstream 100 bases:

>100_bases
ACCGAGAGATATCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTGTTGAAAAGAATAAGGTTGTGCTTCCTTATTTTTC
TGTTGACTGGCGTTTTTGAC

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK

Sequences:

>Translated_617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK
>Mature_617_residues
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVERVASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVARAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPSTVWDTALLSYALQEAQVSKD
NKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVNTTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQ
NNDGGWGAFEKGVTSKLLAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEHIQHEDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYAHIYPLLTLAHYLKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=626, Percent_Identity=23.0031948881789, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI47933397, Length=626, Percent_Identity=23.0031948881789, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI224177558, Length=626, Percent_Identity=23.0031948881789, Blast_Score=120, Evalue=5e-27,
Organism=Homo sapiens, GI224177556, Length=563, Percent_Identity=22.7353463587922, Blast_Score=115, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321863, Length=292, Percent_Identity=27.7397260273973, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69983; Mature: 69983

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
RVASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPS
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQNNDGGWGAFEKGVTSKLLAK
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEEECC
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEHIQHEDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYLKKYRK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYEKAHEEIVRRATALQTMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVE
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHH
RVASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASKKYTKEDANMKRAENFIQERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAIHGEYEYPSLFHLPTPIMFLQNDSPFSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREDRSPVFQTLLSDVKQIISYPLSLHHKGYEEIERFMK
HHHHHHHCCCCHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSMIQKAIAGITSYIWKMERGNHLQNSPS
HHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
TVWDTALLSYALQEAQVSKDNKMIQNATAYLLKKQHTKKADWSVHAPALTPGGWGFSDVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCC
TTIPDIDDTTAVLRALARSRGNKNIDNAWKKGGNWIKGLQNNDGGWGAFEKGVTSKLLAK
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHHHHHH
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQIQRAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHCCCCEEECC
GICYIYGTWAVMTGLRSLGIPSSNPSLKRAASWLEHIQHEDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPAIRKGVSYLLSNPYVNERYPTGTGLPGAFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHH
HIYPLLTLAHYLKKYRK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]