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The map label for this gene is mutS

Identifier: 49478253

GI number: 49478253

Start: 3322650

End: 3324551

Strand: Reverse

Name: mutS

Synonym: BT9727_3259

Alternate gene names: 49478253

Gene position: 3324551-3322650 (Counterclockwise)

Preceding gene: 49478255

Following gene: 49478986

Centisome position: 63.47

GC content: 32.02

Gene sequence:

>1902_bases
ATGAATACGATGACTTTTGAAAAGTTACAATATAACGAATTAAAGGATATAGTGAAATTTTATTGTGTAAGTGGATTAGG
AAAAGAATTAATAAATAAATTAGAGCCGAGTACGAGTATAAAAGTGGTAAGGAATCGATTAAATGAAACAACCGAAGCGC
GAGCTATATTAGATGCAGAAGGGCATGTGCCTTTTTTCGGTATTTCAAATATTGCTAGTACAATTCAAAAATTAGAAAAA
GGAATGATTTTAGATCCAGAAGAGTTAGTAAGTGTTTCAGACTTTTTACGCGGGTGTAGAAAGATTAAAAAATTTATGTT
AGATAAAGAATTTTTTGCACCAGTATTAGCTTCTTATGCAAATTCAATGACTGAATATAAAAGTATTGAAGAGGAAATTA
ACTTTTCAATTAAAGGAAATAGTATTGATTCTGCCGCTAGTAAAGAGTTAAAACGAATTCGAAATAACATTGATTCGGTA
GACGGGAAAATAAAAGAACGTTTAACGAAGTTTTTAAATAGTAGTGCAAATAAGAAGTATATTCAAGAATTCTTTATTAG
TAAGAAGGATGATAGGTATACGATTCCGATTAAATCTTCTTATAAAAATCAAGTTGCGGGAAGTATAGTTGAAGCGTCGG
CTAAAGGTTCTACTGTATTTATAGAACCGCATACGGTTACAAAGTTAAATGCGGAACTTGCAAGTTTGAAAGCAGAAGAA
GCGATGGAAGAATATCAAATTTTAGCGACTTTATCAGGAATGGTAGTAGAAAATATATATCATATAAAAATTAATATGGA
ATTAATTAGTCAGTATGATATGGTGTTTGCGAAAGCGAAGTTTAGTAAATCAATCGATGGAATAGAGCCGAAGTTAAATG
ATCATGGCTATATTCATTTAGTAAATTGTAAGCATCCGCTTTTAAGTGGAAAAGTAGTACCGTTAAACTTTGAAATCGGT
CAAAACTATCGTAGTTTAATTATTACAGGGCCAAATGCGGGCGGTAAGACAATTGTGCTAAAAACAATTGGATTACTAAC
ATTAGCGACGATGTCAGGTCTTCATATTGCTGGAGATAAAGAAACAGAAATTGCTATTTTCGAAAATGTATTTGTAGATA
TTGGTGATAATCAAAGTATCGAAAATGCACTCAGTACGTTTTCATCACATATGAAAAATTTATCTGAGATTATGAGGATG
TCAAATAATAATACGTTGCTATTGTTTGATGAAATAGGAAGCGGGACTGAACCGAACGAAGGAGCAGCACTTGCAATTTC
TATTTTAGAGGAGTTTTATCTTGCCGGATGTATTACAGTTGCGAGTACGCATTACGGTGAAATTAAACGCTTCTCAGAAA
TGCACGATGATTTTATGAATGCAGCAATGCAATTTAATAGTGAGACGCTAGAACCGCTTTATAAATTAGTGATCGGTAAA
TCAGGTGAAAGTAATGCACTTTGGATTGCAAATAAAATGAACGTAAGAGAACATGTACTGAAAAGAGCGAAAGCGTACAT
GGGAAATAAAGAATATACTTTAGAAAAAGTGAATGAAAGTAAAATTAGAAAACCGAAATTCCTGCAAGAAAAAAGAGAAA
ATCATTACGAGTATAAAATTGGCGATCGTGTAAATTTATTGGATCATGATGATTTTGGTATCATCTATAAGGAAAAAGAT
AACTTCTATAATGTCGTTGTATATTATAACGGTGAATTCATTGAAGTGAATGTAAAACGTATTACTTTAGAGGTAGCAGC
AAAGGAGTTATATCCAGAGGGATACGATTTAAATACACTATTTGTCGATTATAAAGAAAGAAAAATGCAACATGATATTG
AGCGCGGATCGAAAAAAGCACTTCGTAACATTCAAAAAGAAATGAGAAAGAATAGAGGGTAA

Upstream 100 bases:

>100_bases
ATGTATAAAAATGGTAATTGAATAATGTAGAGCTCATTGGAATCTAATGAGTAGGTATCTTCATTTATGATAAAAATCAA
TCATAGTGAGGAGAAACAAA

Downstream 100 bases:

>100_bases
TCCAGAGTGGTAACGATTAGACAAGAACGACAAACCGATTATAGAAAAACGGAAGAAGTTGTACAACAAGCATTTTTAAA
TGAAGAATTTAGTGATAAAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNTMTFEKLQYNELKDIVKFYCVSGLGKELINKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVREHVLKRAKAYMGNKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRNIQKEMRKNRG

Sequences:

>Translated_633_residues
MNTMTFEKLQYNELKDIVKFYCVSGLGKELINKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVREHVLKRAKAYMGNKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRNIQKEMRKNRG
>Mature_633_residues
MNTMTFEKLQYNELKDIVKFYCVSGLGKELINKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKYIQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLSGKVVPLNFEIG
QNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVREHVLKRAKAYMGNKEYTLEKVNESKIRKPKFLQEKRENHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFIEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRNIQKEMRKNRG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=285, Percent_Identity=26.6666666666667, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI36949366, Length=509, Percent_Identity=23.7721021611002, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4504191, Length=285, Percent_Identity=24.5614035087719, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI26638666, Length=217, Percent_Identity=29.9539170506912, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4505253, Length=217, Percent_Identity=29.9539170506912, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI26638664, Length=217, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI262231786, Length=217, Percent_Identity=29.0322580645161, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4557761, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789089, Length=273, Percent_Identity=25.2747252747253, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=322, Percent_Identity=24.8447204968944, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=187, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539736, Length=306, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=210, Percent_Identity=27.6190476190476, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319935, Length=396, Percent_Identity=27.5252525252525, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=299, Percent_Identity=26.4214046822742, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=249, Percent_Identity=23.2931726907631, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=324, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24584320, Length=301, Percent_Identity=28.9036544850498, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24664545, Length=542, Percent_Identity=21.7712177121771, Blast_Score=90, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 71904; Mature: 71904

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTFEKLQYNELKDIVKFYCVSGLGKELINKLEPSTSIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNIDSVDGKIKERLTKFLNSSANKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHL
HHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLSGKVVPLNFEIGQNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCEECCCC
ETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVREHVLKRAKAYMGNKEYTLEKVNESKIRKPKFLQEKRENHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHCCHHHCCCCHHHHHHHCCCCEEEE
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFIEVNVKRITLEVAAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEEEHHHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRNIQKEMRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTMTFEKLQYNELKDIVKFYCVSGLGKELINKLEPSTSIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDSAASKELKRIRNNIDSVDGKIKERLTKFLNSSANKKY
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIVEASAKGSTVFIEPHTVTKLNAELASLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHH
AMEEYQILATLSGMVVENIYHIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHL
HHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLSGKVVPLNFEIGQNYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHCCCEECCCC
ETEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEEFYLAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVREHVLKRAKAYMGNKEYTLEKVNESKIRKPKFLQEKRENHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHCCHHHCCCCHHHHHHHCCCCEEEE
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFIEVNVKRITLEVAAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEEEHHHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRNIQKEMRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA