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The map label for this gene is yrkL [H]

Identifier: 49478222

GI number: 49478222

Start: 3269402

End: 3269938

Strand: Reverse

Name: yrkL [H]

Synonym: BT9727_3199

Alternate gene names: 49478222

Gene position: 3269938-3269402 (Counterclockwise)

Preceding gene: 49478224

Following gene: 49479265

Centisome position: 62.43

GC content: 32.59

Gene sequence:

>537_bases
ATGATGAGAACACTTGTAATTGTAGCACACCCTCATATTGAAAAATCAAAAATTAATAAAAGATGGATAGAAGAACTTGA
GAAACATTCAGATGAAATTACGGTGCATGAATTATATAAAGTGGCACCAAACTGGGAGTTTAATATTGAAGAAGAGCAAA
AGTTATTAGTAGAACATGACAGATATATATTTCAATTCCCGCTATACTGGTACAGCACACCGCCATTATTAAAAAAATGG
TTTGATGATGTATTAACATATGGATTTGCGTACGGATCAAAAGGGGATAAAGTGAAGGGAAAAGAGTTTGGTGTAGCTAT
TTCTATAGGTGGATTAGAAAAAGATTATGAAAATAGCGGAATTACGATGGATGAGTTGACGAAACCATTCCAAGCTACAT
GCCTATATACAGGTATGGAATTTATACCTTCCTTTTATTTATATGGTGCCGAATATAAACTAAGTGATGAAGAGATTGAT
AAAAGTGCGCCTGAGTATGTGCAATATGTAATGAATAAGAAGTATTCTAATATATAA

Upstream 100 bases:

>100_bases
CAAGGTTCCTATAGCACCTCAAAGTACGTACTTTTCAATTATATGTAATGCATTCATACTAATACGTAAAGGATTGAATC
ATTTATAAAGGGGATGAAAA

Downstream 100 bases:

>100_bases
GAAGAAACAGCCATTTACTTGTGAAGTAAATGGCTGTTTATTATTTGTTTTATATTCACTAAGTGTAATCTTTAGTAAAT
TAATAGTTAATCTGGTAAAA

Product: NAD(P)H oxidoreductase

Products: NAD(P); reduced acceptor [C]

Alternate protein names: NA

Number of amino acids: Translated: 178; Mature: 178

Protein sequence:

>178_residues
MMRTLVIVAHPHIEKSKINKRWIEELEKHSDEITVHELYKVAPNWEFNIEEEQKLLVEHDRYIFQFPLYWYSTPPLLKKW
FDDVLTYGFAYGSKGDKVKGKEFGVAISIGGLEKDYENSGITMDELTKPFQATCLYTGMEFIPSFYLYGAEYKLSDEEID
KSAPEYVQYVMNKKYSNI

Sequences:

>Translated_178_residues
MMRTLVIVAHPHIEKSKINKRWIEELEKHSDEITVHELYKVAPNWEFNIEEEQKLLVEHDRYIFQFPLYWYSTPPLLKKW
FDDVLTYGFAYGSKGDKVKGKEFGVAISIGGLEKDYENSGITMDELTKPFQATCLYTGMEFIPSFYLYGAEYKLSDEEID
KSAPEYVQYVMNKKYSNI
>Mature_178_residues
MMRTLVIVAHPHIEKSKINKRWIEELEKHSDEITVHELYKVAPNWEFNIEEEQKLLVEHDRYIFQFPLYWYSTPPLLKKW
FDDVLTYGFAYGSKGDKVKGKEFGVAISIGGLEKDYENSGITMDELTKPFQATCLYTGMEFIPSFYLYGAEYKLSDEEID
KSAPEYVQYVMNKKYSNI

Specific function: Unknown

COG id: COG2249

COG function: function code R; Putative NADPH-quinone reductase (modulator of drug activity B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD(P)H dehydrogenase (quinone) family [H]

Homologues:

Organism=Homo sapiens, GI156564357, Length=96, Percent_Identity=38.5416666666667, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786231, Length=168, Percent_Identity=34.5238095238095, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789750, Length=173, Percent_Identity=32.9479768786127, Blast_Score=99, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003680 [H]

Pfam domain/function: PF02525 Flavodoxin_2 [H]

EC number: 1.6.99.- [C]

Molecular weight: Translated: 20979; Mature: 20979

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRTLVIVAHPHIEKSKINKRWIEELEKHSDEITVHELYKVAPNWEFNIEEEQKLLVEHD
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCHHHHHHHHCC
RYIFQFPLYWYSTPPLLKKWFDDVLTYGFAYGSKGDKVKGKEFGVAISIGGLEKDYENSG
CEEEEECHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
ITMDELTKPFQATCLYTGMEFIPSFYLYGAEYKLSDEEIDKSAPEYVQYVMNKKYSNI
CCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMRTLVIVAHPHIEKSKINKRWIEELEKHSDEITVHELYKVAPNWEFNIEEEQKLLVEHD
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCCCHHHHHHHHCC
RYIFQFPLYWYSTPPLLKKWFDDVLTYGFAYGSKGDKVKGKEFGVAISIGGLEKDYENSG
CEEEEECHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
ITMDELTKPFQATCLYTGMEFIPSFYLYGAEYKLSDEEIDKSAPEYVQYVMNKKYSNI
CCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; acceptor [C]

Specific reaction: NAD(P)H2 + acceptor = NAD(P) + reduced acceptor [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]