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The map label for this gene is lysA [H]

Identifier: 49476269

GI number: 49476269

Start: 1869043

End: 1870308

Strand: Reverse

Name: lysA [H]

Synonym: BH16170

Alternate gene names: 49476269

Gene position: 1870308-1869043 (Counterclockwise)

Preceding gene: 49476271

Following gene: 49476268

Centisome position: 96.85

GC content: 42.65

Gene sequence:

>1266_bases
ATGCGTTTTTTTTCTTATAATCAGGGTGTCCTTCACGCTGAAGGTCTTTCTCTTTCTGCATTGGCGCAGGATGTGGGAAC
ACCTTTTTATTGTTATTCAGCCAGTGCAGTGGTGACAAATTTTAAAGACTATCAAAACGCCTTTCTGGATATGCCTAGCT
TGATTGCTTATGCAGTTAAGGCTAATTCTAATCAAGCAGTGTTACGGCTTTTAGCGGCAAACGGAGCGGGAGCTGATGTG
GTTTCAGAAGGTGAATTGCGACGCGCACTTGCTGCTGGTATTCCTGCTCATCGTATTGTTTATTCTGGTGTTGGCAAAAC
AGTAAAGGAGATAGATTTTGCTCTTGCACACGATATTTACTGTTTTAACGTTGAATCAGAGCCTGAACTTGAACAACTTT
CGGTATGTGCTGTTGCGCTTTCAAAAACAGCACGCGTTTCATTGCGCATTAATCCAGATGTAGATGCAAGGACTCATAGA
AAAATTACAACGGGGAAATCTGAAAATAAATTTGGTATTCCACTGTCTTTGGCGTGGGATGTATATAAAAAAGCAGCTCA
ATTACCAGGCATTCAGGTGTGTGGGGTAGATATGCATATTGGCAGTCAGATCTGTGATCTGAAACCGTTTGAAGATGCAT
TTCTTATTGTTGCAGATTTTGTGCGTCAGTTAAGGAGTCATGGCTATGCACTTACCCATATCGATATTGGGGGCGGTCTT
GGTATTGACTATGGGAATGAACATCATTCAGTACCATCTCTTTCTGATTATGCAGCACTTGTAAGGAAGCATATTGCGCC
TTTAGGGATTCATATTATCCTGGAGCCTGGGCGCAGTATTGTCGGCGATGCTGGCGTGTTGGTGACCTCTGTTCTCTACT
TAAAAAGAGGGAATGGACGCAATTTTGTTATTGTGGATGCGGCAATGAATGATCTTATGCGTCCAACACTCTATGATGCT
TGGCAAAATGTACTACTTGTGGAACAAGCATCAAAAGATGCATTACTTATGAAAGCAGATATTGTTGGTGCAGTTTGTGA
AACCGGTGATTATCTAGCATTAGATCGTCGTGTACCGACCTTGGCGACAGGTGATCTTTTAGCCATTATGGAGGCTGGTG
CTTACGGTGCTGTGATGGCAAGCACTTATAATAGCCGACTTTTGGTGCCAGAAGTTCTCGTTCAGGATACGCGTTATGCG
GTTATTCGTCCACGTCTTGATTATGCACAATTGATAGGCTGTGATTATGTTCCAGATTGGATTTGA

Upstream 100 bases:

>100_bases
CTTCTTCAATGATAGAGAAAACGACGCAAGAGACATTTTCTTCCAAAAACAAATTAGATAAACCTTTTATTCTCGACCGA
TTGATACAGTAGAGGTTTTT

Downstream 100 bases:

>100_bases
GTTCAGATGAGATTGAACATTGTTCAATGTTTTTGGTCTTATTTTTACTAAACTTTGATGAAACAATTTATTTCCTGGAA
ATTGTCTTGTATGAATTTTA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MRFFSYNQGVLHAEGLSLSALAQDVGTPFYCYSASAVVTNFKDYQNAFLDMPSLIAYAVKANSNQAVLRLLAANGAGADV
VSEGELRRALAAGIPAHRIVYSGVGKTVKEIDFALAHDIYCFNVESEPELEQLSVCAVALSKTARVSLRINPDVDARTHR
KITTGKSENKFGIPLSLAWDVYKKAAQLPGIQVCGVDMHIGSQICDLKPFEDAFLIVADFVRQLRSHGYALTHIDIGGGL
GIDYGNEHHSVPSLSDYAALVRKHIAPLGIHIILEPGRSIVGDAGVLVTSVLYLKRGNGRNFVIVDAAMNDLMRPTLYDA
WQNVLLVEQASKDALLMKADIVGAVCETGDYLALDRRVPTLATGDLLAIMEAGAYGAVMASTYNSRLLVPEVLVQDTRYA
VIRPRLDYAQLIGCDYVPDWI

Sequences:

>Translated_421_residues
MRFFSYNQGVLHAEGLSLSALAQDVGTPFYCYSASAVVTNFKDYQNAFLDMPSLIAYAVKANSNQAVLRLLAANGAGADV
VSEGELRRALAAGIPAHRIVYSGVGKTVKEIDFALAHDIYCFNVESEPELEQLSVCAVALSKTARVSLRINPDVDARTHR
KITTGKSENKFGIPLSLAWDVYKKAAQLPGIQVCGVDMHIGSQICDLKPFEDAFLIVADFVRQLRSHGYALTHIDIGGGL
GIDYGNEHHSVPSLSDYAALVRKHIAPLGIHIILEPGRSIVGDAGVLVTSVLYLKRGNGRNFVIVDAAMNDLMRPTLYDA
WQNVLLVEQASKDALLMKADIVGAVCETGDYLALDRRVPTLATGDLLAIMEAGAYGAVMASTYNSRLLVPEVLVQDTRYA
VIRPRLDYAQLIGCDYVPDWI
>Mature_421_residues
MRFFSYNQGVLHAEGLSLSALAQDVGTPFYCYSASAVVTNFKDYQNAFLDMPSLIAYAVKANSNQAVLRLLAANGAGADV
VSEGELRRALAAGIPAHRIVYSGVGKTVKEIDFALAHDIYCFNVESEPELEQLSVCAVALSKTARVSLRINPDVDARTHR
KITTGKSENKFGIPLSLAWDVYKKAAQLPGIQVCGVDMHIGSQICDLKPFEDAFLIVADFVRQLRSHGYALTHIDIGGGL
GIDYGNEHHSVPSLSDYAALVRKHIAPLGIHIILEPGRSIVGDAGVLVTSVLYLKRGNGRNFVIVDAAMNDLMRPTLYDA
WQNVLLVEQASKDALLMKADIVGAVCETGDYLALDRRVPTLATGDLLAIMEAGAYGAVMASTYNSRLLVPEVLVQDTRYA
VIRPRLDYAQLIGCDYVPDWI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=345, Percent_Identity=27.8260869565217, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI16506287, Length=351, Percent_Identity=25.0712250712251, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI22538418, Length=385, Percent_Identity=23.8961038961039, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI21361583, Length=385, Percent_Identity=23.8961038961039, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789203, Length=415, Percent_Identity=33.2530120481928, Blast_Score=164, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=23.8356164383562, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24586472, Length=348, Percent_Identity=26.7241379310345, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=350, Percent_Identity=24.5714285714286, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45716; Mature: 45716

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFFSYNQGVLHAEGLSLSALAQDVGTPFYCYSASAVVTNFKDYQNAFLDMPSLIAYAVK
CCEEECCCCEEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCHHHHEEEEE
ANSNQAVLRLLAANGAGADVVSEGELRRALAAGIPAHRIVYSGVGKTVKEIDFALAHDIY
CCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCEE
CFNVESEPELEQLSVCAVALSKTARVSLRINPDVDARTHRKITTGKSENKFGIPLSLAWD
EEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEHHHH
VYKKAAQLPGIQVCGVDMHIGSQICDLKPFEDAFLIVADFVRQLRSHGYALTHIDIGGGL
HHHHHHHCCCEEEEEEEHHCCCHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GIDYGNEHHSVPSLSDYAALVRKHIAPLGIHIILEPGRSIVGDAGVLVTSVLYLKRGNGR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHHHHHEECCCCC
NFVIVDAAMNDLMRPTLYDAWQNVLLVEQASKDALLMKADIVGAVCETGDYLALDRRVPT
EEEEEEHHHHHHHCHHHHHHHHCEEEEEECCCCEEEEEHHHHHHHHCCCCEEEECCCCCC
LATGDLLAIMEAGAYGAVMASTYNSRLLVPEVLVQDTRYAVIRPRLDYAQLIGCDYVPDW
CCCCCCCEEHHCCCCCEEEECCCCCEEECHHHHHCCCCEEEEECCCCHHHHHCCCCCCCC
I
C
>Mature Secondary Structure
MRFFSYNQGVLHAEGLSLSALAQDVGTPFYCYSASAVVTNFKDYQNAFLDMPSLIAYAVK
CCEEECCCCEEEECCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCHHHHEEEEE
ANSNQAVLRLLAANGAGADVVSEGELRRALAAGIPAHRIVYSGVGKTVKEIDFALAHDIY
CCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCEE
CFNVESEPELEQLSVCAVALSKTARVSLRINPDVDARTHRKITTGKSENKFGIPLSLAWD
EEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEHHHH
VYKKAAQLPGIQVCGVDMHIGSQICDLKPFEDAFLIVADFVRQLRSHGYALTHIDIGGGL
HHHHHHHCCCEEEEEEEHHCCCHHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCC
GIDYGNEHHSVPSLSDYAALVRKHIAPLGIHIILEPGRSIVGDAGVLVTSVLYLKRGNGR
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHCCHHHHHHHHHHEECCCCC
NFVIVDAAMNDLMRPTLYDAWQNVLLVEQASKDALLMKADIVGAVCETGDYLALDRRVPT
EEEEEEHHHHHHHCHHHHHHHHCEEEEEECCCCEEEEEHHHHHHHHCCCCEEEECCCCCC
LATGDLLAIMEAGAYGAVMASTYNSRLLVPEVLVQDTRYAVIRPRLDYAQLIGCDYVPDW
CCCCCCCEEHHCCCCCEEEECCCCCEEECHHHHHCCCCEEEEECCCCHHHHHCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]