Click here to switch to the map view.

The map label for this gene is sdhB [H]

Identifier: 49476232

GI number: 49476232

Start: 1819889

End: 1820668

Strand: Reverse

Name: sdhB [H]

Synonym: BH15770

Alternate gene names: 49476232

Gene position: 1820668-1819889 (Counterclockwise)

Preceding gene: 49476233

Following gene: 49476208

Centisome position: 94.28

GC content: 41.28

Gene sequence:

>780_bases
ATGGTACAAATTAAGCTTCCCAAAAATTCGCAAGTAAAACCGGGAAAAGTTTGGCCTAAGCCTAAAGATGCTAAGCAACT
TACCGAATTTCATGTTTACCGTTGGTCACCTGATGATGAGGAAAATCCCCATTTGGATACTTATTATGTTGATCGTTCGG
CTTGTGGTCCGATGATTCTTGATGGGTTGCTCTTTATCAAGAATCATATTGATCCAACTTTGACACTTCGTCGATCGTGT
CGTGAAGGTATCTGTGGTTCTTGTGCAATGAATATTGATGGAACAAATACGCTAGCTTGTACCAAAGGGATGGATGATGT
AAAGCACCCCATTAAAGTGTATCCTTTACCCTCTATGCCGGTTGTTAAAGATTTAGTTCCTGATTTGAAGCGCTTTTATG
CGCAGCATCGTGTGATTGAGCCTTGGTTACAAACCGTTTCTCCTGAACCTGCCAAAGAGTGGTTACAAAGTCATTCAGAC
CGCCAAAAAATAGATGGTCTTTATGAGTGCATTTTGTGTGCCTGTTGTCAGACATCATGTCCAAGCTATTGGTGGAATGG
CGATCGTTATTTGGGACCAGCTATTTTACTCCAGGCTTACCGTTGGATTGCTGATTCACGTGATGAGATGTGCGGTGAGC
GTCTTGATAATTTAGAAGATCCTTTTCGTCTCTATCGTTGCCATACGATTATGAATTGTACCCAAACTTGTCCAAAAGGC
TTAAATCCAGCAAAAGCAATTGCTGAGATTAAAAAACTCATGGTTGAACGTCGCCTTTAA

Upstream 100 bases:

>100_bases
GACCTGTCCATATTGATCCCTTAACATCTGAAGCAGATGGGGGTATCGACTTAAAACGTATTGCACCTAAAAAACGTGTT
TACTAAGGGGAGAATGAATT

Downstream 100 bases:

>100_bases
AAGTTAACTGGTTCATGAGGAAATAAAGTAAGGAGTCTATAGGGCTTCTCCATGTTTCTTGTGTTCTCTGTCAAAAAATA
GATGGTCTTTATGAGTGCGT

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MVQIKLPKNSQVKPGKVWPKPKDAKQLTEFHVYRWSPDDEENPHLDTYYVDRSACGPMILDGLLFIKNHIDPTLTLRRSC
REGICGSCAMNIDGTNTLACTKGMDDVKHPIKVYPLPSMPVVKDLVPDLKRFYAQHRVIEPWLQTVSPEPAKEWLQSHSD
RQKIDGLYECILCACCQTSCPSYWWNGDRYLGPAILLQAYRWIADSRDEMCGERLDNLEDPFRLYRCHTIMNCTQTCPKG
LNPAKAIAEIKKLMVERRL

Sequences:

>Translated_259_residues
MVQIKLPKNSQVKPGKVWPKPKDAKQLTEFHVYRWSPDDEENPHLDTYYVDRSACGPMILDGLLFIKNHIDPTLTLRRSC
REGICGSCAMNIDGTNTLACTKGMDDVKHPIKVYPLPSMPVVKDLVPDLKRFYAQHRVIEPWLQTVSPEPAKEWLQSHSD
RQKIDGLYECILCACCQTSCPSYWWNGDRYLGPAILLQAYRWIADSRDEMCGERLDNLEDPFRLYRCHTIMNCTQTCPKG
LNPAKAIAEIKKLMVERRL
>Mature_259_residues
MVQIKLPKNSQVKPGKVWPKPKDAKQLTEFHVYRWSPDDEENPHLDTYYVDRSACGPMILDGLLFIKNHIDPTLTLRRSC
REGICGSCAMNIDGTNTLACTKGMDDVKHPIKVYPLPSMPVVKDLVPDLKRFYAQHRVIEPWLQTVSPEPAKEWLQSHSD
RQKIDGLYECILCACCQTSCPSYWWNGDRYLGPAILLQAYRWIADSRDEMCGERLDNLEDPFRLYRCHTIMNCTQTCPKG
LNPAKAIAEIKKLMVERRL

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=236, Percent_Identity=64.8305084745763, Blast_Score=332, Evalue=3e-91,
Organism=Escherichia coli, GI1786943, Length=234, Percent_Identity=49.1452991452991, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1790596, Length=224, Percent_Identity=32.1428571428571, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17533915, Length=238, Percent_Identity=58.4033613445378, Blast_Score=296, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=63.0434782608696, Blast_Score=299, Evalue=2e-82,
Organism=Drosophila melanogaster, GI17137106, Length=243, Percent_Identity=64.1975308641975, Blast_Score=334, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24643156, Length=234, Percent_Identity=60.6837606837607, Blast_Score=306, Evalue=1e-83,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 29825; Mature: 29825

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.5 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
8.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQIKLPKNSQVKPGKVWPKPKDAKQLTEFHVYRWSPDDEENPHLDTYYVDRSACGPMIL
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCHHHH
DGLLFIKNHIDPTLTLRRSCREGICGSCAMNIDGTNTLACTKGMDDVKHPIKVYPLPSMP
HHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCCHHHCCCEEEECCCCCH
VVKDLVPDLKRFYAQHRVIEPWLQTVSPEPAKEWLQSHSDRQKIDGLYECILCACCQTSC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PSYWWNGDRYLGPAILLQAYRWIADSRDEMCGERLDNLEDPFRLYRCHTIMNCTQTCPKG
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LNPAKAIAEIKKLMVERRL
CCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVQIKLPKNSQVKPGKVWPKPKDAKQLTEFHVYRWSPDDEENPHLDTYYVDRSACGPMIL
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCCCCEEEECCCCCCHHHH
DGLLFIKNHIDPTLTLRRSCREGICGSCAMNIDGTNTLACTKGMDDVKHPIKVYPLPSMP
HHHHHHHHCCCHHHHHHHHHHCCCCCCEEECCCCCCCEEECCCCHHHCCCEEEECCCCCH
VVKDLVPDLKRFYAQHRVIEPWLQTVSPEPAKEWLQSHSDRQKIDGLYECILCACCQTSC
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PSYWWNGDRYLGPAILLQAYRWIADSRDEMCGERLDNLEDPFRLYRCHTIMNCTQTCPKG
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LNPAKAIAEIKKLMVERRL
CCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA