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The map label for this gene is macA [H]

Identifier: 49476202

GI number: 49476202

Start: 1792141

End: 1793367

Strand: Reverse

Name: macA [H]

Synonym: BH15470

Alternate gene names: 49476202

Gene position: 1793367-1792141 (Counterclockwise)

Preceding gene: 49476203

Following gene: 49476201

Centisome position: 92.87

GC content: 40.99

Gene sequence:

>1227_bases
ATGAAAAAAAATTTTATTAAAAATTTTATTAAAAAACGTAAAAAACTTTCCTTTTTATTAATTGCTATATTCCTTATCAT
CTTGTTTTTATGGTTGCGTTCTGTTTTTTTTGGAACATCCTCGCCGGTTTATATGACAGTGGTGGTCAAGCGTGGTGATA
TTGAGGAAAGTATCTTAGCTTCTGGTCTTGTACGCCCTTATCGATTGGTTGCTGTTGGTGCACGTACAACAGGGCGGGTA
GTTTCAATGCGCGTTTTTCCGGGCAGTATTGTGAAAGAAGGCGACCTCTTGGCAGAAATTGATCCTACAGATCAAGAAAA
TGATCTGAAAAGAAAAAAAGCTGCATTATCTCACTATTATGCGAGCTTGCTAGAACAAGAAGCCTATCTCGCCCTTGCAC
AAAAAAATTTAGAGCGTCAGAAAAAAATGATTGGAGTACGCGCTATTTCACGGGCGGAGTTGGATGACGCTGCAACACAA
GTAAAAATACGCGAAGCACAAGTTGCTCAGCTTCGTCAGCAGATTATACAGGCACAAATTGATGTGGACAGTGCAGAGGT
CAATTTAGGCTATACGCGGATTATTGCTCCTTCAGCGGGAACAGTTTTAGCAACGGTTGTGGAAGAAGGGCAGAATGTTA
ACGCTGTTCAATCGGCACCTACAATTGTTATTTTAGGTGATTTGTCAAAAATGACAGTCAAAGCGCAAATTTCAGAAGCC
GATATTCTTAAAGTTCAGCCTGGACAGTCTCTTTATTTTACGGTTTTAGGCAATTCACAACGGCGTTATGAAGGCGTTTT
AGAAAGAGTAGAGCCGGCGCCTGAATCAATTCGCGCTGATGTGAGTATTAATCCTGGTATGGTAGGAGGTTCTAGCGCTC
TCGTCTCATCAGCTATCTATTATAATGGTATTGTGCATGTTGATAATGCAGATAATTTTTTACGCACCTATATGACCGCG
CAAGTTCATATCATTTTGGGTCGTGCTCAGGATGTTCTGTTGATTCCAAGTGATGCTTTGCGTGATGAGACGAACGAGCG
TAAAGCATGGGTTTCTGTTTTGGTAGGGAAAGATAAAGTGGTTGCAAAACAAGTGACTGTTGGGCTTAATAACAAAGTTA
TGGCTGAAATTCTTTCAGGGCTTGAGGAGGGTGAAGTGGTGATCACAGGTTCACCTGATGGAGTGATGCCAGATATTCCT
GATGAACAGAGCAAAAATGAAAGCTAA

Upstream 100 bases:

>100_bases
CGTTGATGAAAGCATTAGGTGGTGGTTGGGATGGTGTTGTTGATGTGTCACGTCCGGAAGTTGTTGATGGTGTACGCCGT
TCGCGTGCAAAGGTAGGGCA

Downstream 100 bases:

>100_bases
AGTATGAAAGCAAAGCAAGCAGATGCTGTCCTCGTTTTGGAAAATATTGTGCGCAAGTTTCCAGCCGGTGAAACATTTGT
CACTGTTTTGAAAGATATCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKKNFIKNFIKKRKKLSFLLIAIFLIILFLWLRSVFFGTSSPVYMTVVVKRGDIEESILASGLVRPYRLVAVGARTTGRV
VSMRVFPGSIVKEGDLLAEIDPTDQENDLKRKKAALSHYYASLLEQEAYLALAQKNLERQKKMIGVRAISRAELDDAATQ
VKIREAQVAQLRQQIIQAQIDVDSAEVNLGYTRIIAPSAGTVLATVVEEGQNVNAVQSAPTIVILGDLSKMTVKAQISEA
DILKVQPGQSLYFTVLGNSQRRYEGVLERVEPAPESIRADVSINPGMVGGSSALVSSAIYYNGIVHVDNADNFLRTYMTA
QVHIILGRAQDVLLIPSDALRDETNERKAWVSVLVGKDKVVAKQVTVGLNNKVMAEILSGLEEGEVVITGSPDGVMPDIP
DEQSKNES

Sequences:

>Translated_408_residues
MKKNFIKNFIKKRKKLSFLLIAIFLIILFLWLRSVFFGTSSPVYMTVVVKRGDIEESILASGLVRPYRLVAVGARTTGRV
VSMRVFPGSIVKEGDLLAEIDPTDQENDLKRKKAALSHYYASLLEQEAYLALAQKNLERQKKMIGVRAISRAELDDAATQ
VKIREAQVAQLRQQIIQAQIDVDSAEVNLGYTRIIAPSAGTVLATVVEEGQNVNAVQSAPTIVILGDLSKMTVKAQISEA
DILKVQPGQSLYFTVLGNSQRRYEGVLERVEPAPESIRADVSINPGMVGGSSALVSSAIYYNGIVHVDNADNFLRTYMTA
QVHIILGRAQDVLLIPSDALRDETNERKAWVSVLVGKDKVVAKQVTVGLNNKVMAEILSGLEEGEVVITGSPDGVMPDIP
DEQSKNES
>Mature_408_residues
MKKNFIKNFIKKRKKLSFLLIAIFLIILFLWLRSVFFGTSSPVYMTVVVKRGDIEESILASGLVRPYRLVAVGARTTGRV
VSMRVFPGSIVKEGDLLAEIDPTDQENDLKRKKAALSHYYASLLEQEAYLALAQKNLERQKKMIGVRAISRAELDDAATQ
VKIREAQVAQLRQQIIQAQIDVDSAEVNLGYTRIIAPSAGTVLATVVEEGQNVNAVQSAPTIVILGDLSKMTVKAQISEA
DILKVQPGQSLYFTVLGNSQRRYEGVLERVEPAPESIRADVSINPGMVGGSSALVSSAIYYNGIVHVDNADNFLRTYMTA
QVHIILGRAQDVLLIPSDALRDETNERKAWVSVLVGKDKVVAKQVTVGLNNKVMAEILSGLEEGEVVITGSPDGVMPDIP
DEQSKNES

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=390, Percent_Identity=37.4358974358974, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082036, Length=371, Percent_Identity=24.7978436657682, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44735; Mature: 44735

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNFIKNFIKKRKKLSFLLIAIFLIILFLWLRSVFFGTSSPVYMTVVVKRGDIEESILA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHH
SGLVRPYRLVAVGARTTGRVVSMRVFPGSIVKEGDLLAEIDPTDQENDLKRKKAALSHYY
HCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ASLLEQEAYLALAQKNLERQKKMIGVRAISRAELDDAATQVKIREAQVAQLRQQIIQAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHC
DVDSAEVNLGYTRIIAPSAGTVLATVVEEGQNVNAVQSAPTIVILGDLSKMTVKAQISEA
CCCCCEEECCEEEEECCCCCHHHHHHHHCCCCCCHHHCCCEEEEEECCCCEEEEEECCCC
DILKVQPGQSLYFTVLGNSQRRYEGVLERVEPAPESIRADVSINPGMVGGSSALVSSAIY
CEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHEECEEECCCCCCCHHHHHHHHHH
YNGIVHVDNADNFLRTYMTAQVHIILGRAQDVLLIPSDALRDETNERKAWVSVLVGKDKV
HCCEEEECCCHHHHHHHHHEEEEEEEECCCCEEEECCHHHCCCCCHHHEEEHEEECCCCE
VAKQVTVGLNNKVMAEILSGLEEGEVVITGSPDGVMPDIPDEQSKNES
EEEHEEECCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKNFIKNFIKKRKKLSFLLIAIFLIILFLWLRSVFFGTSSPVYMTVVVKRGDIEESILA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHH
SGLVRPYRLVAVGARTTGRVVSMRVFPGSIVKEGDLLAEIDPTDQENDLKRKKAALSHYY
HCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ASLLEQEAYLALAQKNLERQKKMIGVRAISRAELDDAATQVKIREAQVAQLRQQIIQAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHC
DVDSAEVNLGYTRIIAPSAGTVLATVVEEGQNVNAVQSAPTIVILGDLSKMTVKAQISEA
CCCCCEEECCEEEEECCCCCHHHHHHHHCCCCCCHHHCCCEEEEEECCCCEEEEEECCCC
DILKVQPGQSLYFTVLGNSQRRYEGVLERVEPAPESIRADVSINPGMVGGSSALVSSAIY
CEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCCHHHEECEEECCCCCCCHHHHHHHHHH
YNGIVHVDNADNFLRTYMTAQVHIILGRAQDVLLIPSDALRDETNERKAWVSVLVGKDKV
HCCEEEECCCHHHHHHHHHEEEEEEEECCCCEEEECCHHHCCCCCHHHEEEHEEECCCCE
VAKQVTVGLNNKVMAEILSGLEEGEVVITGSPDGVMPDIPDEQSKNES
EEEHEEECCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]