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The map label for this gene is ftsI [H]

Identifier: 49475861

GI number: 49475861

Start: 1247423

End: 1249165

Strand: Reverse

Name: ftsI [H]

Synonym: BH11300

Alternate gene names: 49475861

Gene position: 1249165-1247423 (Counterclockwise)

Preceding gene: 49475862

Following gene: 49475860

Centisome position: 64.69

GC content: 38.5

Gene sequence:

>1743_bases
ATGAAATCATACTTTCTCTTTTCGCAGAAAAGAAAGCGCTTAAAAAAACAGTTCAATATTGATAATTTTCCTGTTCGTCG
CTCATATTCTTCTCGTCGACGCTTATTTTTTTCTTCTTTCTGTTTTCTCATTTTATATGGTGTTATGGGGGCTTGTCTTA
TTTCTTATGGGTTTGAAGGGGGACAGATTGAAGAAGCAAAAGGACCACGAGTCCTTCAATTGACTGCACGGCCTGATATT
CTTGATCGTAATGGTCGTTTATTGGCAACAGATATTAAGACCTATTCGCTTTTTGCTGAACCACGACGTATTATTGATGT
CGATGAAACAATAGAATTGCTCTCAACAGTTTTGCCCGATCTCAATTGGCAGGAAACTTATAAACGTCTTAAAAAAAAGT
CCAGTTTTTCTTGGATTCAGCGTGGGTTAACGCCACTACAGAAAGCGCAAATTATGGCTCTTGGTATTCCAGGAATTGGT
TTTCGTACCGAAATTCGTCGTTTTTATCCCAGTGGACCTGTACTTTCACATATTCTCGGCATGGTTAATGTTGATAATCA
GGGAATAGCGGGTATGGAAAAATATATCGATGATGCTGGCTTGAGTGATTTGCGTGCTGCTGGTCTTGCAACGGAAGATT
CTTTAAAGCCAGTTCAACTTTCGATTGATGTGCGTGTTCAGACAATTGTCCATGATGAACTTATGAAGGCAATGAAGCGT
TATAAGGCGATTGCTGCAGGAGCTGTTATTTTAAATATCCACACAAGTGAAGTTTTGGCTTTGGCATCACTACCAGATTT
TGATCCTGGAAATCCTGTTGATGCTTTGAAAAGTGATCGTCTCAATCGGATGACAGCTGGAACTTTTGAAATGGGATCTA
TCATTAAAAGTTTTACGACCGCGATGGCCCTTGATTCAGATATATTCCATTTAAACAGTATCATTGATGCTTCAAAACCT
CTGCAAGCAAGTAGAGGTTTTACTATTCATGATTTTCATGGGAAAAATCGTCCCTTAACGTTATGGGAGGTTTTTATTTA
TTCTTCTAACATTGGTTCTGCTAAGGAGGCAATGGCGATAGGGATTGATGGACATCGTGCTTTTTTGAAACGACTTGGTT
TACTTGATCGAATGACAACAGAATTGCCTGAAGTTGCCCATCCTCTTGTGCCAAATCATTGGAAGGACATCCATTCTATG
ACAATTTCTTTTGGACATGGTATGGCAACAACGCCCTTGCAAACAGCAGTAGCTGCTGCCGCTTTAATGAATGGTGGTTG
GTTAATTGCTCCTACGTTTTTAAAACGCACAAGAGATCAAGCTTTGCAACATGCAAAACAAGTTTTGCAGGCTAAAACGA
GTCAAAATATGCGTTATCTTTATAAATTAAATAGTGATATTGGTTCTGGGCGTAATGCAAAAGTAGAAGGTTATCGCGTT
GGTGGTAAGACAGGAACAGCCGAAAAAGTTGAAAATGGAAAATATTCTAAAACAAAAAATTTCAATAGTTTTCTCGCTGC
TTTTCCCATTGAAGATCCTGATTATGTTGTTTTAACAATTATCGATGAACCTCAGCCTGAAGATGGAAAGTATTCAGCAA
CAGCAGCAATGAATGCAGGGCCGATACTTGCTAATATTATTCGCCGTTCAGCGAATTTTCTTGGAATAAAACCAGATTTT
CAGAAAGAATATGAGCCTATTTTAACCACAGAGAACAGTTTAAGTTTTGTTAAAAAACGGTGA

Upstream 100 bases:

>100_bases
AAGAAGTGATTAAACAAAATCTTTTGGAGGAAGGGAAAGATATTTTAGCAAATAATCGTACTTCTCAGGCGAATGGCGTT
GTTCGAAAAGGTGTGCGGTG

Downstream 100 bases:

>100_bases
AATTCATATAAAGGTGTGTTGTCATGTTGTTTGGAACAATTTTTACAGAATGTCTTGAAGATGAGAATCTTTCTTCAATG
GAAATAACAGGAATCAGTGC

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MKSYFLFSQKRKRLKKQFNIDNFPVRRSYSSRRRLFFSSFCFLILYGVMGACLISYGFEGGQIEEAKGPRVLQLTARPDI
LDRNGRLLATDIKTYSLFAEPRRIIDVDETIELLSTVLPDLNWQETYKRLKKKSSFSWIQRGLTPLQKAQIMALGIPGIG
FRTEIRRFYPSGPVLSHILGMVNVDNQGIAGMEKYIDDAGLSDLRAAGLATEDSLKPVQLSIDVRVQTIVHDELMKAMKR
YKAIAAGAVILNIHTSEVLALASLPDFDPGNPVDALKSDRLNRMTAGTFEMGSIIKSFTTAMALDSDIFHLNSIIDASKP
LQASRGFTIHDFHGKNRPLTLWEVFIYSSNIGSAKEAMAIGIDGHRAFLKRLGLLDRMTTELPEVAHPLVPNHWKDIHSM
TISFGHGMATTPLQTAVAAAALMNGGWLIAPTFLKRTRDQALQHAKQVLQAKTSQNMRYLYKLNSDIGSGRNAKVEGYRV
GGKTGTAEKVENGKYSKTKNFNSFLAAFPIEDPDYVVLTIIDEPQPEDGKYSATAAMNAGPILANIIRRSANFLGIKPDF
QKEYEPILTTENSLSFVKKR

Sequences:

>Translated_580_residues
MKSYFLFSQKRKRLKKQFNIDNFPVRRSYSSRRRLFFSSFCFLILYGVMGACLISYGFEGGQIEEAKGPRVLQLTARPDI
LDRNGRLLATDIKTYSLFAEPRRIIDVDETIELLSTVLPDLNWQETYKRLKKKSSFSWIQRGLTPLQKAQIMALGIPGIG
FRTEIRRFYPSGPVLSHILGMVNVDNQGIAGMEKYIDDAGLSDLRAAGLATEDSLKPVQLSIDVRVQTIVHDELMKAMKR
YKAIAAGAVILNIHTSEVLALASLPDFDPGNPVDALKSDRLNRMTAGTFEMGSIIKSFTTAMALDSDIFHLNSIIDASKP
LQASRGFTIHDFHGKNRPLTLWEVFIYSSNIGSAKEAMAIGIDGHRAFLKRLGLLDRMTTELPEVAHPLVPNHWKDIHSM
TISFGHGMATTPLQTAVAAAALMNGGWLIAPTFLKRTRDQALQHAKQVLQAKTSQNMRYLYKLNSDIGSGRNAKVEGYRV
GGKTGTAEKVENGKYSKTKNFNSFLAAFPIEDPDYVVLTIIDEPQPEDGKYSATAAMNAGPILANIIRRSANFLGIKPDF
QKEYEPILTTENSLSFVKKR
>Mature_580_residues
MKSYFLFSQKRKRLKKQFNIDNFPVRRSYSSRRRLFFSSFCFLILYGVMGACLISYGFEGGQIEEAKGPRVLQLTARPDI
LDRNGRLLATDIKTYSLFAEPRRIIDVDETIELLSTVLPDLNWQETYKRLKKKSSFSWIQRGLTPLQKAQIMALGIPGIG
FRTEIRRFYPSGPVLSHILGMVNVDNQGIAGMEKYIDDAGLSDLRAAGLATEDSLKPVQLSIDVRVQTIVHDELMKAMKR
YKAIAAGAVILNIHTSEVLALASLPDFDPGNPVDALKSDRLNRMTAGTFEMGSIIKSFTTAMALDSDIFHLNSIIDASKP
LQASRGFTIHDFHGKNRPLTLWEVFIYSSNIGSAKEAMAIGIDGHRAFLKRLGLLDRMTTELPEVAHPLVPNHWKDIHSM
TISFGHGMATTPLQTAVAAAALMNGGWLIAPTFLKRTRDQALQHAKQVLQAKTSQNMRYLYKLNSDIGSGRNAKVEGYRV
GGKTGTAEKVENGKYSKTKNFNSFLAAFPIEDPDYVVLTIIDEPQPEDGKYSATAAMNAGPILANIIRRSANFLGIKPDF
QKEYEPILTTENSLSFVKKR

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=537, Percent_Identity=30.3538175046555, Blast_Score=184, Evalue=9e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64692; Mature: 64692

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSYFLFSQKRKRLKKQFNIDNFPVRRSYSSRRRLFFSSFCFLILYGVMGACLISYGFEG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GQIEEAKGPRVLQLTARPDILDRNGRLLATDIKTYSLFAEPRRIIDVDETIELLSTVLPD
CEEECCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHCCCCEECHHHHHHHHHHHCCC
LNWQETYKRLKKKSSFSWIQRGLTPLQKAQIMALGIPGIGFRTEIRRFYPSGPVLSHILG
CCHHHHHHHHHHCCHHHHHHHCCCHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHH
MVNVDNQGIAGMEKYIDDAGLSDLRAAGLATEDSLKPVQLSIDVRVQTIVHDELMKAMKR
HCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHH
YKAIAAGAVILNIHTSEVLALASLPDFDPGNPVDALKSDRLNRMTAGTFEMGSIIKSFTT
HHHHHCCEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AMALDSDIFHLNSIIDASKPLQASRGFTIHDFHGKNRPLTLWEVFIYSSNIGSAKEAMAI
HHHHCCHHHHHHHHHCCCCCCHHCCCCEEEECCCCCCCEEEEEEEEEECCCCCCCCEEEE
GIDGHRAFLKRLGLLDRMTTELPEVAHPLVPNHWKDIHSMTISFGHGMATTPLQTAVAAA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCHHHHHHHHH
ALMNGGWLIAPTFLKRTRDQALQHAKQVLQAKTSQNMRYLYKLNSDIGSGRNAKVEGYRV
HHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEE
GGKTGTAEKVENGKYSKTKNFNSFLAAFPIEDPDYVVLTIIDEPQPEDGKYSATAAMNAG
CCCCCCHHHHCCCCCCCCCCCCHHEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCCCC
PILANIIRRSANFLGIKPDFQKEYEPILTTENSLSFVKKR
HHHHHHHHHCCCEECCCCCHHHCCCCCEECCCCHHHHHCC
>Mature Secondary Structure
MKSYFLFSQKRKRLKKQFNIDNFPVRRSYSSRRRLFFSSFCFLILYGVMGACLISYGFEG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GQIEEAKGPRVLQLTARPDILDRNGRLLATDIKTYSLFAEPRRIIDVDETIELLSTVLPD
CEEECCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHCCCCEECHHHHHHHHHHHCCC
LNWQETYKRLKKKSSFSWIQRGLTPLQKAQIMALGIPGIGFRTEIRRFYPSGPVLSHILG
CCHHHHHHHHHHCCHHHHHHHCCCHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHH
MVNVDNQGIAGMEKYIDDAGLSDLRAAGLATEDSLKPVQLSIDVRVQTIVHDELMKAMKR
HCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHH
YKAIAAGAVILNIHTSEVLALASLPDFDPGNPVDALKSDRLNRMTAGTFEMGSIIKSFTT
HHHHHCCEEEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
AMALDSDIFHLNSIIDASKPLQASRGFTIHDFHGKNRPLTLWEVFIYSSNIGSAKEAMAI
HHHHCCHHHHHHHHHCCCCCCHHCCCCEEEECCCCCCCEEEEEEEEEECCCCCCCCEEEE
GIDGHRAFLKRLGLLDRMTTELPEVAHPLVPNHWKDIHSMTISFGHGMATTPLQTAVAAA
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCCHHHHHHHHH
ALMNGGWLIAPTFLKRTRDQALQHAKQVLQAKTSQNMRYLYKLNSDIGSGRNAKVEGYRV
HHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEEE
GGKTGTAEKVENGKYSKTKNFNSFLAAFPIEDPDYVVLTIIDEPQPEDGKYSATAAMNAG
CCCCCCHHHHCCCCCCCCCCCCHHEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCCCC
PILANIIRRSANFLGIKPDFQKEYEPILTTENSLSFVKKR
HHHHHHHHHCCCEECCCCCHHHCCCCCEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]