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The map label for this gene is glmS

Identifier: 49475737

GI number: 49475737

Start: 1093818

End: 1095641

Strand: Reverse

Name: glmS

Synonym: BH09920

Alternate gene names: 49475737

Gene position: 1095641-1093818 (Counterclockwise)

Preceding gene: 49475738

Following gene: 49475735

Centisome position: 56.74

GC content: 39.91

Gene sequence:

>1824_bases
ATGTGTGGAATTATCGGAATTCTTGGAAAAAGATGTGTTACATCCTCTTTGGTTGAAAGTTTAAAGCGCCTTGAGTATAG
AGGGTATGATTCATCTGGTATCGCAACAGTTCATAATGGGCGTCTTTATCGTATACGGGCCGAAGGGAAGCTTGTTCATT
TAGAAGAAAAATTACAGAAAACGCCTTTAAAAGGAAATTTAGGGATTGGCCACACGCGTTGGGCTACGCATGGAGTTGCT
GTGGAGCGGAATGCTCATCCTCATGTAACGGAACGGCTTGCAATTGTTCATAATGGTATTATTGAAAATTTTGTAGAATT
GCAAAAAGAACTCATTGAAGATGGTTATACCTTTGAAACAGAGACGGATACAGAGGTTATTGCTCATTTAATTACGCGCG
CGTTAAAAAGTGGTCTTTCTCCACAAGAAGCGATACGCACAAGTTGGAAACGGTTGCAGGGGGCTTTTGCTATTGTTGTT
ATTTTTGAGGGTGAAGACAATCTTATGATTGCTGCTCGTTCTGGTCCTCCATTGGCAATTGGCTATGGAAAAGATGAGTT
TTTTGTCGGATCGGATGCAATTGCTTTGGCTCCATTCGTAGATTCTATCAGCTATATGGAAGATGGGGATTGGGCTGTTC
TGACACGGGAAGATATAACAATTTATGATGTAGATAATCAACCGGTAAAACGTCCTCTTACCCCATTATTTGAAGGAGCT
TTATTGGCTTCTAAGGGTAATCATCGCCATTTCATGCACAAGGAGATGTTTGAACAGCCTGAAGTTATTTCTCATAATTT
GGCGCATTATCTTGATCTTGGCAATTATACGGTTCGCTCGTTTCAAAAATTGATTGATTGGAAGAAAATTAATAGAATAC
TCTTTGCAAGCTGTGGAACAGCTTATTATTCAACCTTAGTTGCACGCTATTGGTTTGAGAGTTTTGCTGCTTTAAGTGTT
GATAATGATGTTGCTTCAGAATTTCGTTATCGTGAACCACCCATCAATTCTGATGTATTGTCGGTGTTTGTTTCTCAATC
TGGTGAAACAGCTGATACATTGGCATCTTTGCGTTATTGTCGTGAATATGGTGTAAAAACAGCAACAATTGTAAATGTTG
AACAATCGACGATGGCAAGAGAAGCTGATTTTGTCTTACCAACACGAGCCGGTCCAGAAATTGGTGTGGCTTCAACAAAA
GCTTTTACTTGTCAATTGGCAACTCTTGCTGCAATGGCCCTTGATGCTGCTAAGCAACGTGGTTTCCTTGCAGAGCAGGC
AGAACATCAGTTTGTCCAGCAATTGGCAGAAGTTCCTAGAATTTTAAACGAGGTTTTAAAGCTAGATAATAAAATTGAAC
AGATTTGTCGGAATTTAGTAAACGTAAAAGGTGTTCTTTATCTAGGGCGTGGTACCTCTTATCCAATTGCGTTAGAAGGC
GCGCTTAAACTGAAGGAGCTTTCTTATATTCATGCAGAAGGCTATGCGGCGGGTGAGTTAAAACATGGGCCGATTGCATT
GGTGGATGAGGCAATACCTGTTATTGTTGTAGCACCTTATGATCGGTGGTTTGAAAAGACTTGTTCTAACATGCAAGAAG
TAGCAGCGCGCAATGGTCGTATTATTTTGATAACTGATAAAAAAGGGGCAGAGGCAGTTCATCTTGATATTTTGTCAACT
ATTGTTTTGCCAAATATTCCAGAATTTATTGCGCCTATTATTTATGCTTTACCCATTCAGTTAATTGCTTATCACACAGC
TGTTTTATTGGGAACGGATGTTGACCAACCCCGTAATTTAGCAAAATCAGTCACTGTTGAGTGA

Upstream 100 bases:

>100_bases
ATATATATGTGATTTATTTGATACCTGAAAGTTTTGAAGGAAGATAATTTAATTATTTTATGAAATTATATAAATTTCAA
ATATGAGTTGGAGCTTTTTA

Downstream 100 bases:

>100_bases
AAATATGTATTTTTGAAACTTTGGGAGAATAATTAGGAATACAAAAAATTAATTTAGTTTTTCATATATTGAATGAGTAT
ATTGAATACAAGAATATTTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQKTPLKGNLGIGHTRWATHGVA
VERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFETETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVV
IFEGEDNLMIAARSGPPLAIGYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGA
LLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGTAYYSTLVARYWFESFAALSV
DNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYCREYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTK
AFTCQLATLAAMALDAAKQRGFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEG
ALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGRIILITDKKGAEAVHLDILST
IVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQKTPLKGNLGIGHTRWATHGVA
VERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFETETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVV
IFEGEDNLMIAARSGPPLAIGYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGA
LLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGTAYYSTLVARYWFESFAALSV
DNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYCREYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTK
AFTCQLATLAAMALDAAKQRGFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEG
ALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGRIILITDKKGAEAVHLDILST
IVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQKTPLKGNLGIGHTRWATHGVA
VERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFETETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVV
IFEGEDNLMIAARSGPPLAIGYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGA
LLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGTAYYSTLVARYWFESFAALSV
DNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYCREYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTK
AFTCQLATLAAMALDAAKQRGFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEG
ALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGRIILITDKKGAEAVHLDILST
IVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI205277386, Length=688, Percent_Identity=36.1918604651163, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=35.5167394468704, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=47.2995090016367, Blast_Score=547, Evalue=1e-157,
Organism=Escherichia coli, GI1788651, Length=260, Percent_Identity=29.6153846153846, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87082251, Length=324, Percent_Identity=20.3703703703704, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=428, Percent_Identity=38.785046728972, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17532897, Length=428, Percent_Identity=38.785046728972, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=37.5291375291375, Blast_Score=286, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322745, Length=433, Percent_Identity=39.0300230946882, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=440, Percent_Identity=30.4545454545455, Blast_Score=183, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=33.6585365853659, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.4651162790698, Blast_Score=387, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_BARHE (Q6G322)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033778.1
- ProteinModelPortal:   Q6G322
- SMR:   Q6G322
- GeneID:   2864740
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH09920
- NMPDR:   fig|283166.1.peg.906
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- PhylomeDB:   Q6G322
- ProtClustDB:   PRK00331
- BioCyc:   BHEN283166:BH09920-MONOMER
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 67362; Mature: 67362

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 602-602

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEEECCCCEEEEHHHHHH
TPLKGNLGIGHTRWATHGVAVERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFET
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
ETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVVIFEGEDNLMIAARSGPPLAI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGA
ECCCCCEEECCCCEEHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCCCCHHHCCC
LLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGT
EEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
AYYSTLVARYWFESFAALSVDNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYC
HHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
REYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTKAFTCQLATLAAMALDAAKQR
HHHCCCEEEEEECHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC
ALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGR
CHHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
IILITDKKGAEAVHLDILSTIVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNL
EEEEECCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIIGILGKRCVTSSLVESLKRLEYRGYDSSGIATVHNGRLYRIRAEGKLVHLEEKLQK
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEEECCCCEEEEHHHHHH
TPLKGNLGIGHTRWATHGVAVERNAHPHVTERLAIVHNGIIENFVELQKELIEDGYTFET
CCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
ETDTEVIAHLITRALKSGLSPQEAIRTSWKRLQGAFAIVVIFEGEDNLMIAARSGPPLAI
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GYGKDEFFVGSDAIALAPFVDSISYMEDGDWAVLTREDITIYDVDNQPVKRPLTPLFEGA
ECCCCCEEECCCCEEHHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCCCCCCCHHHCCC
LLASKGNHRHFMHKEMFEQPEVISHNLAHYLDLGNYTVRSFQKLIDWKKINRILFASCGT
EEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCH
AYYSTLVARYWFESFAALSVDNDVASEFRYREPPINSDVLSVFVSQSGETADTLASLRYC
HHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
REYGVKTATIVNVEQSTMAREADFVLPTRAGPEIGVASTKAFTCQLATLAAMALDAAKQR
HHHCCCEEEEEECHHHHHHHHCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GFLAEQAEHQFVQQLAEVPRILNEVLKLDNKIEQICRNLVNVKGVLYLGRGTSYPIALEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEECC
ALKLKELSYIHAEGYAAGELKHGPIALVDEAIPVIVVAPYDRWFEKTCSNMQEVAARNGR
CHHHHHHHEEECCCCCCCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCE
IILITDKKGAEAVHLDILSTIVLPNIPEFIAPIIYALPIQLIAYHTAVLLGTDVDQPRNL
EEEEECCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA