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The map label for this gene is nuoD [H]

Identifier: 49475655

GI number: 49475655

Start: 1008307

End: 1009497

Strand: Reverse

Name: nuoD [H]

Synonym: BH08920

Alternate gene names: 49475655

Gene position: 1009497-1008307 (Counterclockwise)

Preceding gene: 49475656

Following gene: 49475654

Centisome position: 52.28

GC content: 41.14

Gene sequence:

>1191_bases
GTGGCCGAGGTCAATGTTCGAAACTTTAATATCAATTTTGGTCCGCAACATCCGGCAGCGCATGGTGTTTTGCGCATGGT
TCTGGAATTGGACGGTGAAGTTGTTGAGCGTGTAGATCCACATATTGGACTCTTACATCGCGGTACTGAAAAATTAATGG
AAACAAAAACGTATCTTCAAGCTGGCCCTTATTTAGATCGTTTGGATTATGTAGCTCCTATGAATCAGGAGCATGCTTTT
GTACTTGCTATTGAAAAATTATTAGGTGTTGAGGTTCCCAAACGAGGGCAGTTAATACGTGTTTTATTTTCAGAAATTGG
GCGTATTCTTAATCATTTGCTTAATGTAACAACGCAGGCAATGGATGTTGGGGCTTTAACACCGCCGCTTTGGGGATTTG
AACAACGTGAAAGATTGATGATTTTTTATGAGCGTGCCTGTGGAGCGCGTCTTCATGCAAATTATTTTCGTCCTGGTGGT
GTGCATCAAGACTTACCGGAATCTTTAGTTGAGGATATTGGTAATTTTATTGATCCGTTTCTTATTGCTCTTGGTAAACT
TGATGCACTTATAACACCAAATCGAATTTTTAAACAGCGTAATGTAGATATTGGTGTGGTCAGTATTGATGAGGCTTGGG
CGCGTGGTTTCTCTGGAGTTATGATTCGTGGAGCTGGTGTGCCATGGGATTTGCGTAAAAGCCAACCTTATGAATGTTAT
GATGAAATGGAATTTGATATTCCTGTAGGGAAAAACAGTGATTGTTATGATCGTTATCTCATTCGTATGGAAGAGATGCG
TCAATCAGCGAAAATTATGCGCCAATGCGTGGATCGCTTACTTAGTACTGAGAAAAACGAACCAGTCTCGAGTTTAGATC
GTAAGATTGTTCCTCCAAAGCGGTGCGAAATGAAAAGTTCAATGGAAGCACTTATTCATCATTTTAAACTTTATACGGAA
GGTTTCCGTACACCTCCTGGTGAGGTATATGTTGCTGTGGAAGCTCCAAAGGGTGAGTTTGGGGTTTATCTTGTTTCTGA
TGGAACAAATAAGCCTTATCGTGTTAAGTTGCGTGCTCCTGGCTTTGCTCATCTTCAAGCCATGGATTTTTTGACTCGAG
GTCATATGTTGGCTGATGCTACAGCTATTTTGGGTTCGATTGATATTGTGTTTGGGGAGGTTGATCGCTAA

Upstream 100 bases:

>100_bases
TTATAGTAGTAAGATTCTCAAATAACTAAATATTTTCAATATAATGAGGATTTTTATTAAAGTTTGATATAAAGTTTATT
AAAAAAGCAAGGGGTTAATT

Downstream 100 bases:

>100_bases
TGTCTGTGCGTCGTCTTGCAGATGATGTCTACCAGCCTGCAGAGTTTTCTTTTACAAAAGAAAATCAGATATGGGTAAAA
AATACTATAGAAAAATATCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQAGPYLDRLDYVAPMNQEHAF
VLAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQAMDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGG
VHQDLPESLVEDIGNFIDPFLIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECY
DEMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPKRCEMKSSMEALIHHFKLYTE
GFRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAPGFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR

Sequences:

>Translated_396_residues
MAEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQAGPYLDRLDYVAPMNQEHAF
VLAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQAMDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGG
VHQDLPESLVEDIGNFIDPFLIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECY
DEMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPKRCEMKSSMEALIHHFKLYTE
GFRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAPGFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR
>Mature_395_residues
AEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQAGPYLDRLDYVAPMNQEHAFV
LAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQAMDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGGV
HQDLPESLVEDIGNFIDPFLIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECYD
EMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPKRCEMKSSMEALIHHFKLYTEG
FRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAPGFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=391, Percent_Identity=62.4040920716113, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI260898743, Length=385, Percent_Identity=61.5584415584416, Blast_Score=503, Evalue=1e-142,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=38.5012919896641, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1789076, Length=395, Percent_Identity=26.5822784810127, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788832, Length=388, Percent_Identity=25.2577319587629, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=58.8832487309645, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=57.3604060913706, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=59.6446700507614, Blast_Score=513, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221459469, Length=386, Percent_Identity=56.4766839378238, Blast_Score=466, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44853; Mature: 44721

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQ
CCCEEEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AGPYLDRLDYVAPMNQEHAFVLAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQA
CCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGGVHQDLPESLVEDIGNFIDPF
HHCCCCCCCCCCCCCCCCEEEEEEHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
LIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECY
HHHHHHHHHHCCCHHHHHHCCCEEEEEEECHHHHCCCCCEEEECCCCCCCCCCCCCCCCC
DEMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPK
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCH
RCEMKSSMEALIHHFKLYTEGFRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR
CCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCC
>Mature Secondary Structure 
AEVNVRNFNINFGPQHPAAHGVLRMVLELDGEVVERVDPHIGLLHRGTEKLMETKTYLQ
CCEEEEEEEEECCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AGPYLDRLDYVAPMNQEHAFVLAIEKLLGVEVPKRGQLIRVLFSEIGRILNHLLNVTTQA
CCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFEQRERLMIFYERACGARLHANYFRPGGVHQDLPESLVEDIGNFIDPF
HHCCCCCCCCCCCCCCCCEEEEEEHHCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHH
LIALGKLDALITPNRIFKQRNVDIGVVSIDEAWARGFSGVMIRGAGVPWDLRKSQPYECY
HHHHHHHHHHCCCHHHHHHCCCEEEEEEECHHHHCCCCCEEEECCCCCCCCCCCCCCCCC
DEMEFDIPVGKNSDCYDRYLIRMEEMRQSAKIMRQCVDRLLSTEKNEPVSSLDRKIVPPK
CCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCH
RCEMKSSMEALIHHFKLYTEGFRTPPGEVYVAVEAPKGEFGVYLVSDGTNKPYRVKLRAP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEEECC
GFAHLQAMDFLTRGHMLADATAILGSIDIVFGEVDR
CCHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA