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The map label for this gene is thrS

Identifier: 49475537

GI number: 49475537

Start: 877916

End: 879892

Strand: Reverse

Name: thrS

Synonym: BH07660

Alternate gene names: 49475537

Gene position: 879892-877916 (Counterclockwise)

Preceding gene: 49475538

Following gene: 49475531

Centisome position: 45.57

GC content: 37.94

Gene sequence:

>1977_bases
ATGTCTTGCTCTGTTTCTCTTTCTTTTCCCGATGGTTCGAAGCGTGATTACCACTCCGAAATGACTGGTTTAGAATTGGC
TGAATCTATTTCTAAATCACTTGCAAAAAAAGCACTCGCCTATAGCCTTAACGGAATCATCCGCGATCTATCCGATCCAA
TAAAACAATCTGGTCAGATAGAAATCATTACCCGCGAAGATACACGTGCTCTTGAGCTCATACGCCATGATTGTGCGCAT
GTCCTAGCCGAAGCAGTACAGGAGCTCTTTCCTGGAACGCAAGTGACAATTGGCCCTGTTATTGAAAATGGTTTTTATTA
TGATTTTGCACGTCAACAACCTTTTACATTGGATGATCTTACTATCATTGAAAAGAAAATGCGTGAAATTATCCAACGCA
ATAAACCTTTTAGAAAAGAAGTTTGGTCTCGTAAAAAAGCCAGAGAAATTTTTTCTGAAAAAGGTGAACTTTATAAGGTT
GAGCTTATCGATAGCATCCCCGATAATCAAGATTTGAAAGTCTATTATCAAGGTGATTGGTTTGATCTTTGCCGTGGTCC
ACATATGCAATCTACTGGACAAATTGGGAATGCTTTCAAACTGATGAAAGTTGCAGGAGCTTATTGGCGTGGAGATGCCA
ATAATCCAATGCTAACGAGAATTTATGGTACAGCATTTGCAAACGAAAATGATTTAAAAGCCTATCTACACATGCTAGAA
GAAGCTGAAAAACGTGATCATCGGCGCTTGGGACGTGAAATGAACTTATTTCATTTTCAAGAAGAAGGACCAGGCATGAT
TTTTTGGCACAAAAAAGGCTGGAAAATGTTTCAAAATTTGATCAACTATATGCGAAGACGTCTCGATGATCATCAATATG
CCGAAGTTAATGCACCGCAAGTTCTCGATAGATCACTATGGGAAATATCTGGTCATTGGGAATGGTACAAGGAAAATATG
TTCAAAGCAATTCCCGCAGCTGAAGATTGGGATAATGAAAATGTTTACGCTCTTAAACCAATGAATTGTCCTGGTCATGT
GCAGATTTTTAAACATGGTTTAAAATCTTACCGCGATTTGCCAACAAGAATCGCTGAATTTGGTGTTGTTCATCGTTATG
AACCCTCAGGTTCTCTTCATGGTCTTATGCGTGTACGGTGCTTTACACAAGATGATGCGCATATTTTTTGTACTGATGAA
CAATTAGCTGATGAATGTCTTAATATTAATGATCTGATCTTATCAACTTATGCTGATTTTGGTTTTAAAGAAATCAGTCT
TAAACTTTCAACACGCCCAGAAAAGCGTGTCGGATCTGACGCATTATGGGATCATGCAGAAAATATTATGGAATCTGTTC
TTAAAACTATTGAGACAAAATCCGCAGGGCAAATCAAAACAAGTATTCTTCCAGGTGAAGGTGCATTTTATGGACCAAAG
TTCGAATATACATTGAAAGATGCTATCGGTCGTGAATGGCAATGTGGAACAACGCAACTAGATTTTAATCTTCCCGAACG
CTTCAATGCATTTTATATTGATAAAGACTCAGAAAAGCGTCAGCCAGTTATGATTCATCGTGCCATTTTTGGATCAATGG
AGCGTTTTCTTGGTATATTAATCGAAAATTTTTCTGGACATATGCCGCTTTGGTTTGCACCTGAACAAATTGTTGTAGCA
ACAATTACATCCGAAGCAAATGAATATGCAAAAAAATTAACAGCAAAGCTTAAATCCGTTGGATTATCTACAACATTAGA
TCTTCGCAATGAAAAAATTAACTATAAAATACGTGAGCACTCTTTACAAAAAGTTCCTGTAATTTTGGTATGTGGTAAAC
GTGAATCTGAAACCAATAGCGTGAATATGCGCCGTTTAGGAAGTACAGAGCAAATCTTCTTGTCTGTAGAAGAAGTGATT
GAGCAACTTAAGAATGAGGCAACCCCTCCGGATTTGCGCCGCGTAATAAATGCCTAA

Upstream 100 bases:

>100_bases
TTGCTAAAAAATGAGCCTAATTGGCCTTAATTGCTTATTACTAAGTTTTCACGAAGCCATCCGCAATCGTTCGCGGAATT
GGATTAAAGGGGTGTGTTTT

Downstream 100 bases:

>100_bases
ATGTTCTAAAAAATGAAAAAAACGATAAAGAGAGAAGAGAGACGTCGTTATCGTGCTCTGTCAAGTACGCGCTTGCATTC
AATTAACTCAAATAGTATTT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQIEIITREDTRALELIRHDCAH
VLAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDLTIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKV
ELIDSIPDNQDLKVYYQGDWFDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLE
EAEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQVLDRSLWEISGHWEWYKENM
FKAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDLPTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDE
QLADECLNINDLILSTYADFGFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPK
FEYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGILIENFSGHMPLWFAPEQIVVA
TITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREHSLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVI
EQLKNEATPPDLRRVINA

Sequences:

>Translated_658_residues
MSCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQIEIITREDTRALELIRHDCAH
VLAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDLTIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKV
ELIDSIPDNQDLKVYYQGDWFDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLE
EAEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQVLDRSLWEISGHWEWYKENM
FKAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDLPTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDE
QLADECLNINDLILSTYADFGFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPK
FEYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGILIENFSGHMPLWFAPEQIVVA
TITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREHSLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVI
EQLKNEATPPDLRRVINA
>Mature_657_residues
SCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQIEIITREDTRALELIRHDCAHV
LAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDLTIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKVE
LIDSIPDNQDLKVYYQGDWFDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLEE
AEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQVLDRSLWEISGHWEWYKENMF
KAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDLPTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDEQ
LADECLNINDLILSTYADFGFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPKF
EYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGILIENFSGHMPLWFAPEQIVVAT
ITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREHSLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVIE
QLKNEATPPDLRRVINA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=647, Percent_Identity=37.8670788253478, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI38570111, Length=627, Percent_Identity=38.1180223285486, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI20070344, Length=666, Percent_Identity=37.0870870870871, Blast_Score=427, Evalue=1e-119,
Organism=Escherichia coli, GI1788013, Length=650, Percent_Identity=49.6923076923077, Blast_Score=672, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=647, Percent_Identity=36.4760432766615, Blast_Score=440, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71984192, Length=647, Percent_Identity=36.4760432766615, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322112, Length=665, Percent_Identity=38.4962406015038, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=450, Percent_Identity=33.5555555555556, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24583842, Length=643, Percent_Identity=37.3250388802488, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI28574141, Length=643, Percent_Identity=37.3250388802488, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24583839, Length=643, Percent_Identity=37.3250388802488, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_BARHE (Q6G3K1)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033578.1
- ProteinModelPortal:   Q6G3K1
- SMR:   Q6G3K1
- GeneID:   2865222
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH07660
- NMPDR:   fig|283166.1.peg.706
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q6G3K1
- ProtClustDB:   PRK00413
- BioCyc:   BHEN283166:BH07660-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75910; Mature: 75778

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQI
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EIITREDTRALELIRHDCAHVLAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCCHHH
TIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKVELIDSIPDNQDLKVYYQGDW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCH
FDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLE
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHH
EAEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQ
HHHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VLDRSLWEISGHWEWYKENMFKAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
PTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDEQLADECLNINDLILSTYADF
HHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHCCHHHHHHHHHHCC
GFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPK
CCEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
FEYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGIL
EEEEHHHHCCCCCCCCCEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IENFSGHMPLWFAPEQIVVATITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREH
HHHCCCCCCEEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHC
SLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVIEQLKNEATPPDLRRVINA
CCCCCCEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure 
SCSVSLSFPDGSKRDYHSEMTGLELAESISKSLAKKALAYSLNGIIRDLSDPIKQSGQI
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
EIITREDTRALELIRHDCAHVLAEAVQELFPGTQVTIGPVIENGFYYDFARQQPFTLDDL
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCCCCCCCHHH
TIIEKKMREIIQRNKPFRKEVWSRKKAREIFSEKGELYKVELIDSIPDNQDLKVYYQGDW
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCH
FDLCRGPHMQSTGQIGNAFKLMKVAGAYWRGDANNPMLTRIYGTAFANENDLKAYLHMLE
HHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEHHCCCCCHHHHHHHHHH
EAEKRDHRRLGREMNLFHFQEEGPGMIFWHKKGWKMFQNLINYMRRRLDDHQYAEVNAPQ
HHHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VLDRSLWEISGHWEWYKENMFKAIPAAEDWDNENVYALKPMNCPGHVQIFKHGLKSYRDL
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
PTRIAEFGVVHRYEPSGSLHGLMRVRCFTQDDAHIFCTDEQLADECLNINDLILSTYADF
HHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCEEEECCHHHHHHHCCHHHHHHHHHHCC
GFKEISLKLSTRPEKRVGSDALWDHAENIMESVLKTIETKSAGQIKTSILPGEGAFYGPK
CCEEEEEEECCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
FEYTLKDAIGREWQCGTTQLDFNLPERFNAFYIDKDSEKRQPVMIHRAIFGSMERFLGIL
EEEEHHHHCCCCCCCCCEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
IENFSGHMPLWFAPEQIVVATITSEANEYAKKLTAKLKSVGLSTTLDLRNEKINYKIREH
HHHCCCCCCEEECCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEHHC
SLQKVPVILVCGKRESETNSVNMRRLGSTEQIFLSVEEVIEQLKNEATPPDLRRVINA
CCCCCCEEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA