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The map label for this gene is mazG [H]

Identifier: 49475512

GI number: 49475512

Start: 848252

End: 849073

Strand: Reverse

Name: mazG [H]

Synonym: BH07410

Alternate gene names: 49475512

Gene position: 849073-848252 (Counterclockwise)

Preceding gene: 49475513

Following gene: 49475509

Centisome position: 43.97

GC content: 34.67

Gene sequence:

>822_bases
GTGTTTGCGTCAAAAGATATCAATGATCTTATCGCAATTGTTGCAGGATTACGAAATCGTGAGAGCGGCTGTATCTGGAA
TATAAAACAAACATTTGAATCCCTCATACCTTATATGCTTGAAGAAGTTTACGAAGTTATTGATGCTATTGAACGGAAAA
ACCGAACAGATCTTTGTGACGAACTCGGTGATCTTCTTTTACAGGTCGTCTATCATGCTACAATTGCTCAAGAAGAAGGT
AGCTTTACTTTTGAAGATGTTGTTTACGCGATTACCTCAAAAATGATTCGTCGCCATCCTCACGTTTTTGGCAATGCAGA
ACAGAAAAAACGCGGTTTTATAGAAGATGAATGGGAGCGAATCAAAAAAACAGAACGGGCTGAACAAAATAAGTGCTACG
AGGCAGTAAATTTACCAACTAATTCCACAACAAGTATTCTTGAAAAAATAAAAAAGCTTCAACCAGCACACCAAGAAGCA
CTTGCTTTACAAAAAGCAGCGGCTACAGTGGGATTTAATTGGCATGAAAGCCATAAATTTTTTGCAAAAATTGAAGAAGA
AATTAATGAACTCAAAGATGCAATAAAAAATGACAAAACATCAGATATAGAAGCAGAATTCGGTGATCTTTATTTTTCTC
TGCTGAATCTCGCGCTTCACTTGAATATTGATTCACAAAAAGCATTAAAAAAAACAAATACAAAATTTCGAAATCGTTTT
ACCTATATTGAAGAAAGCCTATACACACAATCTAAAACACTAGCTAATACATCCTTGAAAGAAATGGAATCTCTTTGGAA
TAAGGCTAAGAATAAAAAGTAA

Upstream 100 bases:

>100_bases
TTGTTGAAAGTTGGGTACGTGAATATCCAGGGCAATGGACTTGGTTACACAGACGTTGGGATAGTTGACTATATCCATAA
CATTTATAGGAGAGATATAA

Downstream 100 bases:

>100_bases
GAAAAATATTAGATTTTATCAATCTAAAAAAGCTCCCCACCTCACTCAGTTCAACTAGCTTGGTACGTTTCATTTAGTTG
AGTTTGCGAAGCGGGACGAA

Product: mazG protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MFASKDINDLIAIVAGLRNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQEEG
SFTFEDVVYAITSKMIRRHPHVFGNAEQKKRGFIEDEWERIKKTERAEQNKCYEAVNLPTNSTTSILEKIKKLQPAHQEA
LALQKAAATVGFNWHESHKFFAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKKTNTKFRNRF
TYIEESLYTQSKTLANTSLKEMESLWNKAKNKK

Sequences:

>Translated_273_residues
MFASKDINDLIAIVAGLRNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQEEG
SFTFEDVVYAITSKMIRRHPHVFGNAEQKKRGFIEDEWERIKKTERAEQNKCYEAVNLPTNSTTSILEKIKKLQPAHQEA
LALQKAAATVGFNWHESHKFFAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKKTNTKFRNRF
TYIEESLYTQSKTLANTSLKEMESLWNKAKNKK
>Mature_273_residues
MFASKDINDLIAIVAGLRNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQEEG
SFTFEDVVYAITSKMIRRHPHVFGNAEQKKRGFIEDEWERIKKTERAEQNKCYEAVNLPTNSTTSILEKIKKLQPAHQEA
LALQKAAATVGFNWHESHKFFAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKKTNTKFRNRF
TYIEESLYTQSKTLANTSLKEMESLWNKAKNKK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=271, Percent_Identity=38.7453874538745, Blast_Score=194, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31602; Mature: 31602

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFASKDINDLIAIVAGLRNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCD
CCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ELGDLLLQVVYHATIAQEEGSFTFEDVVYAITSKMIRRHPHVFGNAEQKKRGFIEDEWER
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHH
IKKTERAEQNKCYEAVNLPTNSTTSILEKIKKLQPAHQEALALQKAAATVGFNWHESHKF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHH
FAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKKTNTKFRNRF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TYIEESLYTQSKTLANTSLKEMESLWNKAKNKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFASKDINDLIAIVAGLRNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCD
CCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ELGDLLLQVVYHATIAQEEGSFTFEDVVYAITSKMIRRHPHVFGNAEQKKRGFIEDEWER
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHH
IKKTERAEQNKCYEAVNLPTNSTTSILEKIKKLQPAHQEALALQKAAATVGFNWHESHKF
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHH
FAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKKTNTKFRNRF
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
TYIEESLYTQSKTLANTSLKEMESLWNKAKNKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]