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The map label for this gene is mutY [H]

Identifier: 49475251

GI number: 49475251

Start: 523173

End: 524279

Strand: Reverse

Name: mutY [H]

Synonym: BH04540

Alternate gene names: 49475251

Gene position: 524279-523173 (Counterclockwise)

Preceding gene: 49475255

Following gene: 49475249

Centisome position: 27.15

GC content: 39.93

Gene sequence:

>1107_bases
ATGCTTTTTTCTTTTGCATTTTATATCTCCCTATGGTTGACAAAAATCATGCATGAAATTTCTTTGCGCCTTCTTTCTTG
GTACGATCAAAAACACCGGCATCTCCCATGGCGTATTACCCCCAAAGAACAAATGCAAGGCATCCGCCCCGATCCTTATC
GCGTTTGGCTTTCTGAAATCATGCTTCAACAAACAACTGTCGAAGCTGTTAAGCCCTATTTTAAAAAATTTCTGCAACTT
TGGCCTGATCTTTCTTCTTTAGCAAAAGCTTCACAAGATGATATCATGAAAGCGTGGGCTGGTCTTGGCTATTATTCACG
CGCACGCAATCTTAAAAATTGTGCTCAGCAGCTCGTTGAAGACTACGGAGGACAATTTCCACAATCTATAAAAGTATTGC
GTTCTCTATCCGGTATTGGAGACTATACTGCTGCAGCTATCGCCGCTATTGCTTTTAACCATCCTGTAGCTGTTGTTGAT
AGTAATGTCGAACGCGTTGTAACACGCTTATTTGCTATCACCTCAGTCTTGCCCAAAGCAAAAGCTGAAATTAAAGAAAA
AACACAAAAAATTACTGCTTTAAATCGCCCAGGCGACTTTGCTCAAGCCATGATGGATCTGGGAGCAACAATTTGCATAC
CACGTAAACCATCTTGTTCCCTCTGCCCTCTTCAAGGTTTATGTAGAGCAGAAAAAATGCAAAAAGCAGAATTTTTTCCA
GTCAAAGCTCCTAAAAAAGAACGTCTTTCAAAAACTGGTGCTGCTTTTGTTGTTCTTAATGAAAAGAGGCAAATTTATCT
AGAAAAACGACAGGGTAAAAAATTACTCGGTGGTATGACCCAAATTCCTAACAATATTGGAACAAAGAACCCAAATGGAC
TCCAAAATGCACCCTTTATTGCCAATTGGCAATTTAAAGGACAAATTACACATGTTTTCACCCATTTTTCTTTGAAACTT
GACGTTTACTATATTAGCGGTATTCGCGAAATAAAACATCAAAATGGCTGGTGGTGCGATATTCATCATCTTGCGGAACA
GGCTCTCCCTACCGTGATGAAAAAAGCCATCGCAGTCGCGATTCCTCACCCCTTCAAGTTAAAATAA

Upstream 100 bases:

>100_bases
CTTTTACCCTCAAAAACTCATTAAATATCGACAAAATCCGATAATTACTTAATCAAAAGTCCTATAATAAGGAAGAAACA
AATTATGAATTGCAAAATAA

Downstream 100 bases:

>100_bases
CGCCCCCACTGAACAGATGAAATATTTAGTAGCGTGAACTGATCATCTTATAAAATACCAGTTTTTAACATCTGTGAACG
TATTACCATTCTTAACTCAT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLFSFAFYISLWLTKIMHEISLRLLSWYDQKHRHLPWRITPKEQMQGIRPDPYRVWLSEIMLQQTTVEAVKPYFKKFLQL
WPDLSSLAKASQDDIMKAWAGLGYYSRARNLKNCAQQLVEDYGGQFPQSIKVLRSLSGIGDYTAAAIAAIAFNHPVAVVD
SNVERVVTRLFAITSVLPKAKAEIKEKTQKITALNRPGDFAQAMMDLGATICIPRKPSCSLCPLQGLCRAEKMQKAEFFP
VKAPKKERLSKTGAAFVVLNEKRQIYLEKRQGKKLLGGMTQIPNNIGTKNPNGLQNAPFIANWQFKGQITHVFTHFSLKL
DVYYISGIREIKHQNGWWCDIHHLAEQALPTVMKKAIAVAIPHPFKLK

Sequences:

>Translated_368_residues
MLFSFAFYISLWLTKIMHEISLRLLSWYDQKHRHLPWRITPKEQMQGIRPDPYRVWLSEIMLQQTTVEAVKPYFKKFLQL
WPDLSSLAKASQDDIMKAWAGLGYYSRARNLKNCAQQLVEDYGGQFPQSIKVLRSLSGIGDYTAAAIAAIAFNHPVAVVD
SNVERVVTRLFAITSVLPKAKAEIKEKTQKITALNRPGDFAQAMMDLGATICIPRKPSCSLCPLQGLCRAEKMQKAEFFP
VKAPKKERLSKTGAAFVVLNEKRQIYLEKRQGKKLLGGMTQIPNNIGTKNPNGLQNAPFIANWQFKGQITHVFTHFSLKL
DVYYISGIREIKHQNGWWCDIHHLAEQALPTVMKKAIAVAIPHPFKLK
>Mature_368_residues
MLFSFAFYISLWLTKIMHEISLRLLSWYDQKHRHLPWRITPKEQMQGIRPDPYRVWLSEIMLQQTTVEAVKPYFKKFLQL
WPDLSSLAKASQDDIMKAWAGLGYYSRARNLKNCAQQLVEDYGGQFPQSIKVLRSLSGIGDYTAAAIAAIAFNHPVAVVD
SNVERVVTRLFAITSVLPKAKAEIKEKTQKITALNRPGDFAQAMMDLGATICIPRKPSCSLCPLQGLCRAEKMQKAEFFP
VKAPKKERLSKTGAAFVVLNEKRQIYLEKRQGKKLLGGMTQIPNNIGTKNPNGLQNAPFIANWQFKGQITHVFTHFSLKL
DVYYISGIREIKHQNGWWCDIHHLAEQALPTVMKKAIAVAIPHPFKLK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=364, Percent_Identity=34.8901098901099, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI6912520, Length=364, Percent_Identity=34.8901098901099, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI115298654, Length=364, Percent_Identity=34.8901098901099, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI115298652, Length=364, Percent_Identity=34.8901098901099, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI115298650, Length=364, Percent_Identity=34.8901098901099, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI190358497, Length=364, Percent_Identity=34.8901098901099, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI1789331, Length=316, Percent_Identity=35.7594936708861, Blast_Score=197, Evalue=7e-52,
Organism=Escherichia coli, GI1787920, Length=179, Percent_Identity=25.1396648044693, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41880; Mature: 41880

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSFAFYISLWLTKIMHEISLRLLSWYDQKHRHLPWRITPKEQMQGIRPDPYRVWLSEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCCCCHHHHHHHHH
MLQQTTVEAVKPYFKKFLQLWPDLSSLAKASQDDIMKAWAGLGYYSRARNLKNCAQQLVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DYGGQFPQSIKVLRSLSGIGDYTAAAIAAIAFNHPVAVVDSNVERVVTRLFAITSVLPKA
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
KAEIKEKTQKITALNRPGDFAQAMMDLGATICIPRKPSCSLCPLQGLCRAEKMQKAEFFP
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
VKAPKKERLSKTGAAFVVLNEKRQIYLEKRQGKKLLGGMTQIPNNIGTKNPNGLQNAPFI
CCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCEE
ANWQFKGQITHVFTHFSLKLDVYYISGIREIKHQNGWWCDIHHLAEQALPTVMKKAIAVA
EEEEECCCCEEEEEEEEEEEEEEEHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHC
IPHPFKLK
CCCCCCCC
>Mature Secondary Structure
MLFSFAFYISLWLTKIMHEISLRLLSWYDQKHRHLPWRITPKEQMQGIRPDPYRVWLSEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCCCCHHHHHHHHH
MLQQTTVEAVKPYFKKFLQLWPDLSSLAKASQDDIMKAWAGLGYYSRARNLKNCAQQLVE
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
DYGGQFPQSIKVLRSLSGIGDYTAAAIAAIAFNHPVAVVDSNVERVVTRLFAITSVLPKA
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
KAEIKEKTQKITALNRPGDFAQAMMDLGATICIPRKPSCSLCPLQGLCRAEKMQKAEFFP
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
VKAPKKERLSKTGAAFVVLNEKRQIYLEKRQGKKLLGGMTQIPNNIGTKNPNGLQNAPFI
CCCCHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHCCHHHCCCCCCCCCCCCCCCCCEE
ANWQFKGQITHVFTHFSLKLDVYYISGIREIKHQNGWWCDIHHLAEQALPTVMKKAIAVA
EEEEECCCCEEEEEEEEEEEEEEEHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHC
IPHPFKLK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]