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The map label for this gene is thrC [H]

Identifier: 49475245

GI number: 49475245

Start: 516419

End: 517816

Strand: Reverse

Name: thrC [H]

Synonym: BH04480

Alternate gene names: 49475245

Gene position: 517816-516419 (Counterclockwise)

Preceding gene: 49475246

Following gene: 49475244

Centisome position: 26.82

GC content: 39.41

Gene sequence:

>1398_bases
ATGCAATATATCAGCACGAGAGGTGAGGCTCCTGCTTTAGGTTTTATTGAAACTATCATGACTGGACTGGCTAGTGATGG
TGGACTTTATCTTCCAGAAAAATTCCCCCAATTATCATTCGATGCATTACGAGCGCTTCGTGGCCAATCCTATATGACAA
TCGCTAAAACTATTCTTTGGCCCTTTGTGAATAACGAAATTGAATATACTTCTTTTGAAAATATGATTTCTGAATCTTAT
GCTACCTTCCATCATCCTGCAACCTGTCCGTTACTGCAAACTGGCCCAAATGAATTTATTCTTGAACTTTTTCACGGTCC
TACTTTGGCATTTAAAGATGTTGCAATGCAGTTTCTTTCTCGACTGATGGATTATGTGCTCATCAAAAAAAATAAATCCG
CAACAATTATTGCTGCTACATCAGGTGATACAGGTGGTGCCGCAATACAAGCTTTTGCTGGAAGAGAATATTCAGACGTT
TTTATCTTGTTTCCTAAAGGGCGTATATCACCCGTTCAGCAGCGGCAAATGACGACCAGTCAAAAAACAAACGTGCATGC
CATAGCCATTGAAGGGAGTTTTGATGATTGCCAAGCACTGGTGAAAGCAATGTTTAATGACCATAATTTCCGGCAAAAAA
AAGCACTTTCAGGAGTTAATTCTATAAATTGGGCGCGTATTATGGCGCAAATTGTTTATTATTTTTCATCCGCACTTTCT
TTAGGTGCTCCTGATAGAGCTGTCTCATTTACTGTTCCTACTGGAAATTTTGGTGATATTTTTGCGGGTTATGTTGCTGC
CCGTATGGGATTACCCATTGCCCAATTGGTCATTGCAACAAATGATAATGATATCCTCGTGCGCACATTGACTAATGGTA
CTTATGAAACACAGCCGACAACCCACACAACGTCACCCTCTATGGATATTCAAGTCTCTTCTAATTTTGAACGCTTACTG
TTTGAAAGTGGCGATCGTGATCCTGTGTGGATTCGCAATGCGATGGAAAACTTGAAAAAGTCAGGATATTTTAATCTTAA
TGAAAAGCAGCTCAAAAATATTCGTTCCCTCTTTTCTGCAGGGAAAAGTAGCATAGCTGAAACGGCAAAAATAATTGACA
GTGTTTATAAGGAAAGCGGCTATCTCGTTGATCCACATACAGCTGTTGCGCTTAAAGTAGCCCGTGAAAACAGACAACCA
CATATTCCAATGATCGTCCTCTCTACTGCTCATCCTGCTAAATTTCCTGATGCCATCAAAAATGCCTGTGGACTTAATGC
TCCATGGCCATCTCGTCTCAACGATTTAATAGAACGCGAAGAACATTTTATAGGTCTTGCTAATGATGAAAAAATAGTAA
AAGATTACATTTCTTTAAAATCGCGTGCATCTTATTAA

Upstream 100 bases:

>100_bases
AAACAAATCAATTTCTATTGATTGAATAATTTAAATATTATGAAAAACATGAAATAAATAACTTGACCAACTCGTCGGAA
ATAAACAAAGGAAAAAACTT

Downstream 100 bases:

>100_bases
ACTTAGCTGCATTAATTCAGATTAACAATATTCCAATACTCTATAATAATTAAAGTATTTGGCTTGTTTAACGGAGTCAT
GAACACATGGGTGTAGATAT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MQYISTRGEAPALGFIETIMTGLASDGGLYLPEKFPQLSFDALRALRGQSYMTIAKTILWPFVNNEIEYTSFENMISESY
ATFHHPATCPLLQTGPNEFILELFHGPTLAFKDVAMQFLSRLMDYVLIKKNKSATIIAATSGDTGGAAIQAFAGREYSDV
FILFPKGRISPVQQRQMTTSQKTNVHAIAIEGSFDDCQALVKAMFNDHNFRQKKALSGVNSINWARIMAQIVYYFSSALS
LGAPDRAVSFTVPTGNFGDIFAGYVAARMGLPIAQLVIATNDNDILVRTLTNGTYETQPTTHTTSPSMDIQVSSNFERLL
FESGDRDPVWIRNAMENLKKSGYFNLNEKQLKNIRSLFSAGKSSIAETAKIIDSVYKESGYLVDPHTAVALKVARENRQP
HIPMIVLSTAHPAKFPDAIKNACGLNAPWPSRLNDLIEREEHFIGLANDEKIVKDYISLKSRASY

Sequences:

>Translated_465_residues
MQYISTRGEAPALGFIETIMTGLASDGGLYLPEKFPQLSFDALRALRGQSYMTIAKTILWPFVNNEIEYTSFENMISESY
ATFHHPATCPLLQTGPNEFILELFHGPTLAFKDVAMQFLSRLMDYVLIKKNKSATIIAATSGDTGGAAIQAFAGREYSDV
FILFPKGRISPVQQRQMTTSQKTNVHAIAIEGSFDDCQALVKAMFNDHNFRQKKALSGVNSINWARIMAQIVYYFSSALS
LGAPDRAVSFTVPTGNFGDIFAGYVAARMGLPIAQLVIATNDNDILVRTLTNGTYETQPTTHTTSPSMDIQVSSNFERLL
FESGDRDPVWIRNAMENLKKSGYFNLNEKQLKNIRSLFSAGKSSIAETAKIIDSVYKESGYLVDPHTAVALKVARENRQP
HIPMIVLSTAHPAKFPDAIKNACGLNAPWPSRLNDLIEREEHFIGLANDEKIVKDYISLKSRASY
>Mature_465_residues
MQYISTRGEAPALGFIETIMTGLASDGGLYLPEKFPQLSFDALRALRGQSYMTIAKTILWPFVNNEIEYTSFENMISESY
ATFHHPATCPLLQTGPNEFILELFHGPTLAFKDVAMQFLSRLMDYVLIKKNKSATIIAATSGDTGGAAIQAFAGREYSDV
FILFPKGRISPVQQRQMTTSQKTNVHAIAIEGSFDDCQALVKAMFNDHNFRQKKALSGVNSINWARIMAQIVYYFSSALS
LGAPDRAVSFTVPTGNFGDIFAGYVAARMGLPIAQLVIATNDNDILVRTLTNGTYETQPTTHTTSPSMDIQVSSNFERLL
FESGDRDPVWIRNAMENLKKSGYFNLNEKQLKNIRSLFSAGKSSIAETAKIIDSVYKESGYLVDPHTAVALKVARENRQP
HIPMIVLSTAHPAKFPDAIKNACGLNAPWPSRLNDLIEREEHFIGLANDEKIVKDYISLKSRASY

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=452, Percent_Identity=34.7345132743363, Blast_Score=265, Evalue=7e-71,
Organism=Homo sapiens, GI153792148, Length=452, Percent_Identity=35.6194690265487, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1786185, Length=434, Percent_Identity=33.1797235023041, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319901, Length=460, Percent_Identity=43.4782608695652, Blast_Score=342, Evalue=8e-95,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51570; Mature: 51570

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYISTRGEAPALGFIETIMTGLASDGGLYLPEKFPQLSFDALRALRGQSYMTIAKTILW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVNNEIEYTSFENMISESYATFHHPATCPLLQTGPNEFILELFHGPTLAFKDVAMQFLS
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RLMDYVLIKKNKSATIIAATSGDTGGAAIQAFAGREYSDVFILFPKGRISPVQQRQMTTS
HHHHHHEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHC
QKTNVHAIAIEGSFDDCQALVKAMFNDHNFRQKKALSGVNSINWARIMAQIVYYFSSALS
CCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
LGAPDRAVSFTVPTGNFGDIFAGYVAARMGLPIAQLVIATNDNDILVRTLTNGTYETQPT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEEECCCC
THTTSPSMDIQVSSNFERLLFESGDRDPVWIRNAMENLKKSGYFNLNEKQLKNIRSLFSA
CCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GKSSIAETAKIIDSVYKESGYLVDPHTAVALKVARENRQPHIPMIVLSTAHPAKFPDAIK
CHHHHHHHHHHHHHHHHCCCCEECCCHHEEEEEHHHCCCCCCCEEEEECCCCCCCHHHHH
NACGLNAPWPSRLNDLIEREEHFIGLANDEKIVKDYISLKSRASY
HHCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQYISTRGEAPALGFIETIMTGLASDGGLYLPEKFPQLSFDALRALRGQSYMTIAKTILW
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVNNEIEYTSFENMISESYATFHHPATCPLLQTGPNEFILELFHGPTLAFKDVAMQFLS
HHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
RLMDYVLIKKNKSATIIAATSGDTGGAAIQAFAGREYSDVFILFPKGRISPVQQRQMTTS
HHHHHHEEECCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHC
QKTNVHAIAIEGSFDDCQALVKAMFNDHNFRQKKALSGVNSINWARIMAQIVYYFSSALS
CCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
LGAPDRAVSFTVPTGNFGDIFAGYVAARMGLPIAQLVIATNDNDILVRTLTNGTYETQPT
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEEECCCC
THTTSPSMDIQVSSNFERLLFESGDRDPVWIRNAMENLKKSGYFNLNEKQLKNIRSLFSA
CCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GKSSIAETAKIIDSVYKESGYLVDPHTAVALKVARENRQPHIPMIVLSTAHPAKFPDAIK
CHHHHHHHHHHHHHHHHCCCCEECCCHHEEEEEHHHCCCCCCCEEEEECCCCCCCHHHHH
NACGLNAPWPSRLNDLIEREEHFIGLANDEKIVKDYISLKSRASY
HHCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]