Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 49475016

GI number: 49475016

Start: 276328

End: 277695

Strand: Reverse

Name: pepA [H]

Synonym: BH02040

Alternate gene names: 49475016

Gene position: 277695-276328 (Counterclockwise)

Preceding gene: 49475017

Following gene: 49475015

Centisome position: 14.38

GC content: 39.47

Gene sequence:

>1368_bases
ATGCATTTACATCACATTCATTTTACTTCAACACGTATTGATAATAGTTGTCCCATATTTTTGGTAAACCAGAGAAGTCT
GGCTGATTTATCGCTTGATGCATCAACAACAGCATGGATAAAAGTTAATGATTTCACTGGTAAAGCAGGGCAAATACTCT
TCATTCCTCACGAAACAGGGCATTTAAAAAAAGTTCTCTTTGGACTTGGTAATGGTGATGAACCTTTTATCACAGGGCTT
CTCGCTAAAAATCTTCCTGCTGGAAATTGGCACCTAGAAGGAACTGCCTCTCATGAAATAAATAACTATCTTGGTTTGGC
ATTCGGAAGTTATCAATTTAACCGTTATCGTCAAAATTCTTCTTCAAAGTCCTTATCATTTTACGTTAACGATACGGTTG
ATCTCAATGAACTTAAACGAATTTATGAAACTGTCTTTTTTGTTCGTGATCTCATCAATATTCCTGCCAATGATATGAAC
CCCGATATCCTCGAGAAAGAAACACGCCATCTGGGAAAAACCTACGGTGCTGATGTCCAAAGCATTTGTGGAGATGAACT
TTTAACACATAATTTTCCAATGATCCATGCCGTAGGACGAGCTAGCAATACTGTACCACGACTCATTGAGTTACATTGGG
GGCAAGAAAACCACCCTAAAATAACGTTGGTTGGCAAAGGCGTAACCTTCGATACTGGAGGACTCGATATTAAATCAGCC
AATAATATGTTGCTCATGAAAAAAGATATGGGAGGAGGTGCACATGTTTTGGGGCTGGCTAAACTTATCATGGATGCCAA
ATTACCCTTTCGTCTGCGTGTTTTAATCCCAGCTGTTGAAAATGCAATTTCCGCCAATGCTTACAGACCAGGCGATATTC
TCAAAAGTCGTAAAGGTTTAAGCGTTGAAATTGGCAATACAGATGCGGAAGGGCGACTTGTCCTTGCCGATGCGCTCGCC
TATGGTGATGAAGAAAGTCCACAATTCATGCTTTGCATGGCAACTTTAACAGGAGCAGCGCATATAGCGTTAGGACCAGA
GCTTCCCGCATTTTATTGTAATGATTCAGTATGGGCACAACAAATTTCTCAATCTGCACATTCTGTTTATGATCCTCTTT
GGCAAATGCCACTTTGGAAACCTTATGAGGAAATGTTATCATCACCAATCGCTGATCTTAACAATATAACTGGAAATAAC
TTTGCTGGCTCCATAGTCGCAGCTTTATTTCTGAATTCTTTTGTTGAAAAAACTAAACATTTTGCGCATTTTGATCTTTA
TGGATGGGTTCCAAAAGAAAAACCAGGCTTTCCTGTTGGCGGTTCAGCACAAGCTATCCGTGCTCTTTATAACCTCTTTA
AAAATTAA

Upstream 100 bases:

>100_bases
CCAACACGACCACGGTCTAATCTCATTCTACGCAAGGGAAAAAAACATTTGGTTGAATATGTGGCACTTCGACGACTATA
GACTATAAAGGTTTCTAAAT

Downstream 100 bases:

>100_bases
GCTTGACGCAAAATGTCCACAAAGATGGATAATTCTGGAGCTTCAGGAGCGATTGCCTATCACCTTGAATTTGCTCTGCG
CTTCCTTTGAAGATAAAATT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MHLHHIHFTSTRIDNSCPIFLVNQRSLADLSLDASTTAWIKVNDFTGKAGQILFIPHETGHLKKVLFGLGNGDEPFITGL
LAKNLPAGNWHLEGTASHEINNYLGLAFGSYQFNRYRQNSSSKSLSFYVNDTVDLNELKRIYETVFFVRDLINIPANDMN
PDILEKETRHLGKTYGADVQSICGDELLTHNFPMIHAVGRASNTVPRLIELHWGQENHPKITLVGKGVTFDTGGLDIKSA
NNMLLMKKDMGGGAHVLGLAKLIMDAKLPFRLRVLIPAVENAISANAYRPGDILKSRKGLSVEIGNTDAEGRLVLADALA
YGDEESPQFMLCMATLTGAAHIALGPELPAFYCNDSVWAQQISQSAHSVYDPLWQMPLWKPYEEMLSSPIADLNNITGNN
FAGSIVAALFLNSFVEKTKHFAHFDLYGWVPKEKPGFPVGGSAQAIRALYNLFKN

Sequences:

>Translated_455_residues
MHLHHIHFTSTRIDNSCPIFLVNQRSLADLSLDASTTAWIKVNDFTGKAGQILFIPHETGHLKKVLFGLGNGDEPFITGL
LAKNLPAGNWHLEGTASHEINNYLGLAFGSYQFNRYRQNSSSKSLSFYVNDTVDLNELKRIYETVFFVRDLINIPANDMN
PDILEKETRHLGKTYGADVQSICGDELLTHNFPMIHAVGRASNTVPRLIELHWGQENHPKITLVGKGVTFDTGGLDIKSA
NNMLLMKKDMGGGAHVLGLAKLIMDAKLPFRLRVLIPAVENAISANAYRPGDILKSRKGLSVEIGNTDAEGRLVLADALA
YGDEESPQFMLCMATLTGAAHIALGPELPAFYCNDSVWAQQISQSAHSVYDPLWQMPLWKPYEEMLSSPIADLNNITGNN
FAGSIVAALFLNSFVEKTKHFAHFDLYGWVPKEKPGFPVGGSAQAIRALYNLFKN
>Mature_455_residues
MHLHHIHFTSTRIDNSCPIFLVNQRSLADLSLDASTTAWIKVNDFTGKAGQILFIPHETGHLKKVLFGLGNGDEPFITGL
LAKNLPAGNWHLEGTASHEINNYLGLAFGSYQFNRYRQNSSSKSLSFYVNDTVDLNELKRIYETVFFVRDLINIPANDMN
PDILEKETRHLGKTYGADVQSICGDELLTHNFPMIHAVGRASNTVPRLIELHWGQENHPKITLVGKGVTFDTGGLDIKSA
NNMLLMKKDMGGGAHVLGLAKLIMDAKLPFRLRVLIPAVENAISANAYRPGDILKSRKGLSVEIGNTDAEGRLVLADALA
YGDEESPQFMLCMATLTGAAHIALGPELPAFYCNDSVWAQQISQSAHSVYDPLWQMPLWKPYEEMLSSPIADLNNITGNN
FAGSIVAALFLNSFVEKTKHFAHFDLYGWVPKEKPGFPVGGSAQAIRALYNLFKN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=290, Percent_Identity=34.8275862068965, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI47155554, Length=312, Percent_Identity=33.6538461538462, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI87082123, Length=350, Percent_Identity=34.2857142857143, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790710, Length=466, Percent_Identity=30.9012875536481, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=284, Percent_Identity=36.9718309859155, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=229, Percent_Identity=32.3144104803493, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357381, Length=284, Percent_Identity=35.2112676056338, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379063, Length=284, Percent_Identity=35.2112676056338, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=284, Percent_Identity=35.2112676056338, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24661038, Length=283, Percent_Identity=31.8021201413428, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21355725, Length=283, Percent_Identity=30.3886925795053, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI20129969, Length=291, Percent_Identity=27.4914089347079, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662227, Length=302, Percent_Identity=26.4900662251656, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355645, Length=287, Percent_Identity=25.7839721254355, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24662223, Length=287, Percent_Identity=25.7839721254355, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922386, Length=301, Percent_Identity=26.9102990033223, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI20129963, Length=330, Percent_Identity=25.1515151515152, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161077148, Length=292, Percent_Identity=27.7397260273973, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130057, Length=292, Percent_Identity=27.7397260273973, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646701, Length=214, Percent_Identity=33.1775700934579, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646703, Length=214, Percent_Identity=33.1775700934579, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21358201, Length=214, Percent_Identity=33.1775700934579, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50248; Mature: 50248

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHHIHFTSTRIDNSCPIFLVNQRSLADLSLDASTTAWIKVNDFTGKAGQILFIPHETG
CCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCC
HLKKVLFGLGNGDEPFITGLLAKNLPAGNWHLEGTASHEINNYLGLAFGSYQFNRYRQNS
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCHHHCCCCEEEECCCHHHHHHCCC
SSKSLSFYVNDTVDLNELKRIYETVFFVRDLINIPANDMNPDILEKETRHLGKTYGADVQ
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
SICGDELLTHNFPMIHAVGRASNTVPRLIELHWGQENHPKITLVGKGVTFDTGGLDIKSA
HHHCCHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCEEEECC
NNMLLMKKDMGGGAHVLGLAKLIMDAKLPFRLRVLIPAVENAISANAYRPGDILKSRKGL
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHCCCCC
SVEIGNTDAEGRLVLADALAYGDEESPQFMLCMATLTGAAHIALGPELPAFYCNDSVWAQ
EEEECCCCCCCEEEEEEHHHCCCCCCCCEEEEEEHHCCCEEEEECCCCCEEEECCHHHHH
QISQSAHSVYDPLWQMPLWKPYEEMLSSPIADLNNITGNNFAGSIVAALFLNSFVEKTKH
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FAHFDLYGWVPKEKPGFPVGGSAQAIRALYNLFKN
HEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHLHHIHFTSTRIDNSCPIFLVNQRSLADLSLDASTTAWIKVNDFTGKAGQILFIPHETG
CCEEEEEEECCCCCCCCCEEEECCCCCCEEEECCCCEEEEEEECCCCCCCEEEEEECCCC
HLKKVLFGLGNGDEPFITGLLAKNLPAGNWHLEGTASHEINNYLGLAFGSYQFNRYRQNS
HHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCHHHCCCCEEEECCCHHHHHHCCC
SSKSLSFYVNDTVDLNELKRIYETVFFVRDLINIPANDMNPDILEKETRHLGKTYGADVQ
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHH
SICGDELLTHNFPMIHAVGRASNTVPRLIELHWGQENHPKITLVGKGVTFDTGGLDIKSA
HHHCCHHHHCCCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEEECCEEECCCCEEEECC
NNMLLMKKDMGGGAHVLGLAKLIMDAKLPFRLRVLIPAVENAISANAYRPGDILKSRKGL
CCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHCCCCCCHHHHHCCCCC
SVEIGNTDAEGRLVLADALAYGDEESPQFMLCMATLTGAAHIALGPELPAFYCNDSVWAQ
EEEECCCCCCCEEEEEEHHHCCCCCCCCEEEEEEHHCCCEEEEECCCCCEEEECCHHHHH
QISQSAHSVYDPLWQMPLWKPYEEMLSSPIADLNNITGNNFAGSIVAALFLNSFVEKTKH
HHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
FAHFDLYGWVPKEKPGFPVGGSAQAIRALYNLFKN
HEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA