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The map label for this gene is fabB [H]

Identifier: 49474946

GI number: 49474946

Start: 170455

End: 171675

Strand: Reverse

Name: fabB [H]

Synonym: BH01280

Alternate gene names: 49474946

Gene position: 171675-170455 (Counterclockwise)

Preceding gene: 49474947

Following gene: 49474945

Centisome position: 8.89

GC content: 43.16

Gene sequence:

>1221_bases
ATGCGTCGAGTTGTTGTAACCGGAATGGGAATTGTCTCCGCGATTGGGAATAACCCAGGAACCGTTTTAACCAGTTTATA
TGAAGCAAAATCCGGGATTTCTTACGCACCTCAGTATGCTAAATTAGGCTTCCGTAGTAGAGTTTACGGTAAACCTGATA
TTAATATAGAAGAACTTGTTGATAGACGTGCTCTGCGTTTTCATGGACGCGGAACGGCATGGAATCATATCGCCATGGAT
CAAGCAATTGCTGATGCGGGTTTAGAGCCCCATGAAGTATCCAATGAACACACAGGGATTATTATGGGCTCTGGAGGAGC
TTCAACGCAGTCAATCGTTGAAGCTGCTGACATTACACGTCAAAAAAGTCCAAAGCGTGTTGGCCCCTTTGTCGTACCTA
AAGCAATGAGTTCTACAGCATCCGCAACACTTGCAACTTTTTTTAAAATTAAAGGAGTGAACTATTCAATCTCTTCTGCT
TGTGCTACCTCTAATCATTGTATTGGAAATGCCTATGAGATGATACAATATGGCAAACAGGATCGCATTTTTGCTGGTGG
CTGCGAAGATCTGGATTGGACATTATCTGTTTTGTTTGATGCCATGGGTGCTATGTCCAGCAAATATAATGACGTACCAG
AAAAAGCTTCTCGTGCTTATGATGCTCATCGGGATGGATTTGTTATTGCAGGTGGAGCTGGCGTTTTGGTTCTTGAAGAA
CTAGAATGCGCTAAAGCACGTGGTGCAAAAATCTATGGAGAAATTGTTGGTTATGGTGCGACATCTGATGGGCATGATAT
GGTTGCTCCATCAGGAGAAGGAGCAGAGCGGTGCATGCGCATGGCACTTGCAACCGTGAAAAATAAAATTGATTACATTA
ATCCTCATGCAACAGCAACGCCTGTTGGGGATCCTCCTGAAATAGAAGCAATTCGTCGTATCTTTGGAGCAGGTGATCAA
TGTCCACCAATTTCCGCCACAAAATCTCTGACTGGTCATTCCTTGGGAGCAGCAGGTGTTCAAGAAGCAATCTATACACT
GTTAATGATGAATCATAATTTTATTTGCGAAAGTGCCCATATTGAAGAGCTTGATCCAGCTTTTGCCGATATGCCAATTG
TTCGTGAACGCCGTGATCATCAACAACTTAATACTGTCTTGTCAAATACCTTTGGCTTTGGCGGTACCAATGCAACGCTC
GTTTTCCAACGTTATGGATAA

Upstream 100 bases:

>100_bases
TAAAGCGAGTGATTTACGCGTTGCTCTCTTCAAAGAAGACTAAAAATTATTTCCATAAGAGGGTATATTTTATTATTCTG
TATGAAACAAGGAGGTATGA

Downstream 100 bases:

>100_bases
ATAGGAACTCTTAGCTGATTAAAAAAGTACGGTCTTACGGAGAATAATATGAAAGGTTTGATGGAGGGCAAACGTGGCCT
TATTATGGGGGTTGCAAATG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRRVVVTGMGIVSAIGNNPGTVLTSLYEAKSGISYAPQYAKLGFRSRVYGKPDINIEELVDRRALRFHGRGTAWNHIAMD
QAIADAGLEPHEVSNEHTGIIMGSGGASTQSIVEAADITRQKSPKRVGPFVVPKAMSSTASATLATFFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDRIFAGGCEDLDWTLSVLFDAMGAMSSKYNDVPEKASRAYDAHRDGFVIAGGAGVLVLEE
LECAKARGAKIYGEIVGYGATSDGHDMVAPSGEGAERCMRMALATVKNKIDYINPHATATPVGDPPEIEAIRRIFGAGDQ
CPPISATKSLTGHSLGAAGVQEAIYTLLMMNHNFICESAHIEELDPAFADMPIVRERRDHQQLNTVLSNTFGFGGTNATL
VFQRYG

Sequences:

>Translated_406_residues
MRRVVVTGMGIVSAIGNNPGTVLTSLYEAKSGISYAPQYAKLGFRSRVYGKPDINIEELVDRRALRFHGRGTAWNHIAMD
QAIADAGLEPHEVSNEHTGIIMGSGGASTQSIVEAADITRQKSPKRVGPFVVPKAMSSTASATLATFFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDRIFAGGCEDLDWTLSVLFDAMGAMSSKYNDVPEKASRAYDAHRDGFVIAGGAGVLVLEE
LECAKARGAKIYGEIVGYGATSDGHDMVAPSGEGAERCMRMALATVKNKIDYINPHATATPVGDPPEIEAIRRIFGAGDQ
CPPISATKSLTGHSLGAAGVQEAIYTLLMMNHNFICESAHIEELDPAFADMPIVRERRDHQQLNTVLSNTFGFGGTNATL
VFQRYG
>Mature_406_residues
MRRVVVTGMGIVSAIGNNPGTVLTSLYEAKSGISYAPQYAKLGFRSRVYGKPDINIEELVDRRALRFHGRGTAWNHIAMD
QAIADAGLEPHEVSNEHTGIIMGSGGASTQSIVEAADITRQKSPKRVGPFVVPKAMSSTASATLATFFKIKGVNYSISSA
CATSNHCIGNAYEMIQYGKQDRIFAGGCEDLDWTLSVLFDAMGAMSSKYNDVPEKASRAYDAHRDGFVIAGGAGVLVLEE
LECAKARGAKIYGEIVGYGATSDGHDMVAPSGEGAERCMRMALATVKNKIDYINPHATATPVGDPPEIEAIRRIFGAGDQ
CPPISATKSLTGHSLGAAGVQEAIYTLLMMNHNFICESAHIEELDPAFADMPIVRERRDHQQLNTVLSNTFGFGGTNATL
VFQRYG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=34.8557692307692, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=26.5671641791045, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI223972627, Length=161, Percent_Identity=38.5093167701863, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788663, Length=406, Percent_Identity=60.5911330049261, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=36.1650485436893, Blast_Score=235, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=33.1730769230769, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=38.2022471910112, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=342, Percent_Identity=24.5614035087719, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=278, Percent_Identity=25.8992805755396, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320904, Length=453, Percent_Identity=31.1258278145695, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=35.3221957040573, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI19920632, Length=337, Percent_Identity=27.5964391691395, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI221330659, Length=337, Percent_Identity=27.5964391691395, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24581345, Length=338, Percent_Identity=22.4852071005917, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43505; Mature: 43505

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGMGIVSAIGNNPGTVLTSLYEAKSGISYAPQYAKLGFRSRVYGKPDINIEELV
CCEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHHH
DRRALRFHGRGTAWNHIAMDQAIADAGLEPHEVSNEHTGIIMGSGGASTQSIVEAADITR
HHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
QKSPKRVGPFVVPKAMSSTASATLATFFKIKGVNYSISSACATSNHCIGNAYEMIQYGKQ
HCCCCCCCCEECCHHHHHHHHHHHHHHHEECCCCEEHHHHHCCCCCCCHHHHHHHHCCCC
DRIFAGGCEDLDWTLSVLFDAMGAMSSKYNDVPEKASRAYDAHRDGFVIAGGAGVLVLEE
CCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEH
LECAKARGAKIYGEIVGYGATSDGHDMVAPSGEGAERCMRMALATVKNKIDYINPHATAT
HHHHHHCCCEEEEHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PVGDPPEIEAIRRIFGAGDQCPPISATKSLTGHSLGAAGVQEAIYTLLMMNHNFICESAH
CCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCC
IEELDPAFADMPIVRERRDHQQLNTVLSNTFGFGGTNATLVFQRYG
HHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRRVVVTGMGIVSAIGNNPGTVLTSLYEAKSGISYAPQYAKLGFRSRVYGKPDINIEELV
CCEEEEECCHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCCCCCHHHHH
DRRALRFHGRGTAWNHIAMDQAIADAGLEPHEVSNEHTGIIMGSGGASTQSIVEAADITR
HHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCEEEEECCCCCHHHHHHHHHHHH
QKSPKRVGPFVVPKAMSSTASATLATFFKIKGVNYSISSACATSNHCIGNAYEMIQYGKQ
HCCCCCCCCEECCHHHHHHHHHHHHHHHEECCCCEEHHHHHCCCCCCCHHHHHHHHCCCC
DRIFAGGCEDLDWTLSVLFDAMGAMSSKYNDVPEKASRAYDAHRDGFVIAGGAGVLVLEE
CCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCCCEEEEEH
LECAKARGAKIYGEIVGYGATSDGHDMVAPSGEGAERCMRMALATVKNKIDYINPHATAT
HHHHHHCCCEEEEHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
PVGDPPEIEAIRRIFGAGDQCPPISATKSLTGHSLGAAGVQEAIYTLLMMNHNFICESAH
CCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCC
IEELDPAFADMPIVRERRDHQQLNTVLSNTFGFGGTNATLVFQRYG
HHHCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]