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The map label for this gene is fabI1 [H]

Identifier: 49474945

GI number: 49474945

Start: 169588

End: 170406

Strand: Reverse

Name: fabI1 [H]

Synonym: BH01270

Alternate gene names: 49474945

Gene position: 170406-169588 (Counterclockwise)

Preceding gene: 49474946

Following gene: 49474933

Centisome position: 8.82

GC content: 39.68

Gene sequence:

>819_bases
ATGAAAGGTTTGATGGAGGGCAAACGTGGCCTTATTATGGGGGTTGCAAATGACCATTCAATTGCTTGGGGCATTGCATG
TCAACTTGCAAAAGCAGGAGCTGAATTAGCATTTACCTATCAAGGAGAGGCTTTTGGAAAACGTGTTCAACCATTAGCAG
AAAAAATCGGCTGCAAATTAGTACTTGAGTGTGACGTTGAAAAAATTGAAAATGTTGACCGCGTCTTTAAACGTCTTGAA
AAAGAATGGAAAACTATAGACTTTGTTGTTCATGCTATTGGTTTTTCAGACAAGACCCAACTAAAAGGACGTTATGTTGA
TGTGACAACACGTGAAAACTTTAAGCGTACAATGGTTATTTCAGCTTATTCCTTTACTGAAATTGCTCAGCGTGCGGGTA
AACTTATGCCTAATGGAGGTACACTTTTAACACTCACTTATGGCGCTTCACAGCAAGTTGTCCCTAATTATAATATCATG
GGTGTTGCTAAAGCTGCTTTAGAAGCTATGGTGCGCTATTTAGCGGCCGACTTTGGTCCTCAAAATATCCGTGTTAATGC
AATTTCAGCCGGTCCTATTAGGACATTAGCTGGCAATGGCATTGCAGCTGCACGAGCAATTTTTTCGTATCAACGTCGAA
ATGCACCCCTACGCCGTAATGTAAACATTAATGAAATCGGAAAATCTGCTCTTTACCTGCTTTCTGATTTATCTTCAGGG
GTTACTGGTGAAATTCATTATGTTGATTCAGGTTATAACATCATGTCTATGCCAACCCTTGAAGAATTAAAACAAAGTGA
AGAAGCTCAAGAAGAGTAA

Upstream 100 bases:

>100_bases
CTTTGGCTTTGGCGGTACCAATGCAACGCTCGTTTTCCAACGTTATGGATAAATAGGAACTCTTAGCTGATTAAAAAAGT
ACGGTCTTACGGAGAATAAT

Downstream 100 bases:

>100_bases
TTATTCCGTAATCCTTTTAAAATAGAAAATGATTACTTGTATACTGTTTTAGAATTATACTGGGCTCTTTCTCTTAGGTA
AATGATACATATAGTGTGAT

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 2 [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKGLMEGKRGLIMGVANDHSIAWGIACQLAKAGAELAFTYQGEAFGKRVQPLAEKIGCKLVLECDVEKIENVDRVFKRLE
KEWKTIDFVVHAIGFSDKTQLKGRYVDVTTRENFKRTMVISAYSFTEIAQRAGKLMPNGGTLLTLTYGASQQVVPNYNIM
GVAKAALEAMVRYLAADFGPQNIRVNAISAGPIRTLAGNGIAAARAIFSYQRRNAPLRRNVNINEIGKSALYLLSDLSSG
VTGEIHYVDSGYNIMSMPTLEELKQSEEAQEE

Sequences:

>Translated_272_residues
MKGLMEGKRGLIMGVANDHSIAWGIACQLAKAGAELAFTYQGEAFGKRVQPLAEKIGCKLVLECDVEKIENVDRVFKRLE
KEWKTIDFVVHAIGFSDKTQLKGRYVDVTTRENFKRTMVISAYSFTEIAQRAGKLMPNGGTLLTLTYGASQQVVPNYNIM
GVAKAALEAMVRYLAADFGPQNIRVNAISAGPIRTLAGNGIAAARAIFSYQRRNAPLRRNVNINEIGKSALYLLSDLSSG
VTGEIHYVDSGYNIMSMPTLEELKQSEEAQEE
>Mature_272_residues
MKGLMEGKRGLIMGVANDHSIAWGIACQLAKAGAELAFTYQGEAFGKRVQPLAEKIGCKLVLECDVEKIENVDRVFKRLE
KEWKTIDFVVHAIGFSDKTQLKGRYVDVTTRENFKRTMVISAYSFTEIAQRAGKLMPNGGTLLTLTYGASQQVVPNYNIM
GVAKAALEAMVRYLAADFGPQNIRVNAISAGPIRTLAGNGIAAARAIFSYQRRNAPLRRNVNINEIGKSALYLLSDLSSG
VTGEIHYVDSGYNIMSMPTLEELKQSEEAQEE

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=92, Percent_Identity=45.6521739130435, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=47.4903474903475, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=26.171875, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=26.4, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=26.0869565217391, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29903; Mature: 29903

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLMEGKRGLIMGVANDHSIAWGIACQLAKAGAELAFTYQGEAFGKRVQPLAEKIGCKL
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEE
VLECDVEKIENVDRVFKRLEKEWKTIDFVVHAIGFSDKTQLKGRYVDVTTRENFKRTMVI
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCCEEEEE
SAYSFTEIAQRAGKLMPNGGTLLTLTYGASQQVVPNYNIMGVAKAALEAMVRYLAADFGP
EEHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QNIRVNAISAGPIRTLAGNGIAAARAIFSYQRRNAPLRRNVNINEIGKSALYLLSDLSSG
CCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
VTGEIHYVDSGYNIMSMPTLEELKQSEEAQEE
CCEEEEEEECCCCEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKGLMEGKRGLIMGVANDHSIAWGIACQLAKAGAELAFTYQGEAFGKRVQPLAEKIGCKL
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCEE
VLECDVEKIENVDRVFKRLEKEWKTIDFVVHAIGFSDKTQLKGRYVDVTTRENFKRTMVI
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECCCCCEEEEE
SAYSFTEIAQRAGKLMPNGGTLLTLTYGASQQVVPNYNIMGVAKAALEAMVRYLAADFGP
EEHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
QNIRVNAISAGPIRTLAGNGIAAARAIFSYQRRNAPLRRNVNINEIGKSALYLLSDLSSG
CCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
VTGEIHYVDSGYNIMSMPTLEELKQSEEAQEE
CCEEEEEEECCCCEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]