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The map label for this gene is pncB

Identifier: 49474913

GI number: 49474913

Start: 116889

End: 118193

Strand: Reverse

Name: pncB

Synonym: BH00910

Alternate gene names: 49474913

Gene position: 118193-116889 (Counterclockwise)

Preceding gene: 49474914

Following gene: 49474902

Centisome position: 6.12

GC content: 39.85

Gene sequence:

>1305_bases
ATGAATCATCCAGACATTGCGAGACGCGTTTACAATCATACCTGGAAACTTGACCCCATTATTCGTTCACTGCTCGATAC
CGATTTTTATAAACTTCTTATGGTACAGATGATTTGGGGGCTTTATCCCAATGTAAACGTTACTTTCTCCCTCATCAACC
GTAGCAAAACAATACGTCTTGCTGATGATATTGATGAAATGGAATTGCGTGCACAACTTGATCACGCCCTTAATTTACGC
TTTACCAAAAAAGAAATGATTTGGCTTGCTGGTAATACATTTTATGGACGTAAACAAATTTTCGAACCAGATTTTCTTCA
GTGGCTTGAGAATTTTCAACTTCCAGAATATGAACTCACACGTAAAGATGGCCAATATATCCTTCATTTCCATGGTCCGT
GGACCCATAGCTCCATGTGGGAAATCCCTGCCCTTTCTATTATAAGTGAATTACGTTCACGTGCTGCTATGAAAAAACTA
GATCGCTTCACTCTTGATGTACTTTATGCGCGTGCTAAAGCAAAAATGTGGAGTAAAGTCGAAAGACTCAAAAAACTGCC
TAATATTAAAATATCTGACTTTGGTACAAGACGTCGCCATTCTTTTTTATGGCAACGTTGGTGCGTTGAAGCATTAAAAG
AAGGAATTGGCAATTCTTTTACCGGAACGTCTAATGTCCTTCTCGCCATGGATACAGATTTAGAAGCTCTTGGTACCAAT
GCACATGAATTGCCTATGGTCATAGCCGCTCTCACCAATAATGATAATGAATTGCGCAAAGCACCTTATCAAGTTTTACA
AGATTGGAATCGTTATTATGGTGGAAATCTTCTCATTGTTTTGCCAGATACCTTCGGTACAGAAGCATTTTTACGCAATG
CACCAGATTGGGTGGCTGATTGGACAGGTTTCAGACCTGACAGTGCTCCTCCTCTCGAGGGCGGCGAACGCATTATTCAA
TGGTGGAGAGAAAAAGGAAAAGACCCTCGTGAAAAGTTATTGATTTTCTCCGATGCACTAGACATAGATACAATTGAAAA
AACCTATCATCATTTTCACGGTAAAGTGCGCATGAGTTTTGGATGGGGAACAGACCTTACTAATGATTTCGTCGGCTGTT
CTCCACAAGAAACTGCAACTTTTGATGCTCTTTCCCTTGTTTGTAAAGTTACCCATGCCAATGGTCGGCCAGCCGTAAAA
CTTTCAGATAATCCTGAAAAAACCATCGGTAATCCGCAAGAAATACAACGTTATCTCAATTTTTTTGGTAATGAAAACCG
TGTTGCTAAACCTATCAAAACATAA

Upstream 100 bases:

>100_bases
CTTGCTCAAAAACTTAGAGTTGTTATAGTCCTTGCAATTTCTATATTGGTGGTGTTGATGCACAAATTTTAGATTTTAAA
AAACTGAAAGAAAAAGGGTT

Downstream 100 bases:

>100_bases
CAATGCTTTTTTAGTTTAACATTTTTTCTTTATGCATATTTTTAAAGATAAGCAGAGAGATTCTTTACAATACAGTAAAA
AGGAAACTTCCAGTACAGGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPNVNVTFSLINRSKTIRLADDIDEMELRAQLDHALNLR
FTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELTRKDGQYILHFHGPWTHSSMWEIPALSIISELRSRAAMKKL
DRFTLDVLYARAKAKMWSKVERLKKLPNIKISDFGTRRRHSFLWQRWCVEALKEGIGNSFTGTSNVLLAMDTDLEALGTN
AHELPMVIAALTNNDNELRKAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLRNAPDWVADWTGFRPDSAPPLEGGERIIQ
WWREKGKDPREKLLIFSDALDIDTIEKTYHHFHGKVRMSFGWGTDLTNDFVGCSPQETATFDALSLVCKVTHANGRPAVK
LSDNPEKTIGNPQEIQRYLNFFGNENRVAKPIKT

Sequences:

>Translated_434_residues
MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPNVNVTFSLINRSKTIRLADDIDEMELRAQLDHALNLR
FTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELTRKDGQYILHFHGPWTHSSMWEIPALSIISELRSRAAMKKL
DRFTLDVLYARAKAKMWSKVERLKKLPNIKISDFGTRRRHSFLWQRWCVEALKEGIGNSFTGTSNVLLAMDTDLEALGTN
AHELPMVIAALTNNDNELRKAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLRNAPDWVADWTGFRPDSAPPLEGGERIIQ
WWREKGKDPREKLLIFSDALDIDTIEKTYHHFHGKVRMSFGWGTDLTNDFVGCSPQETATFDALSLVCKVTHANGRPAVK
LSDNPEKTIGNPQEIQRYLNFFGNENRVAKPIKT
>Mature_434_residues
MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPNVNVTFSLINRSKTIRLADDIDEMELRAQLDHALNLR
FTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELTRKDGQYILHFHGPWTHSSMWEIPALSIISELRSRAAMKKL
DRFTLDVLYARAKAKMWSKVERLKKLPNIKISDFGTRRRHSFLWQRWCVEALKEGIGNSFTGTSNVLLAMDTDLEALGTN
AHELPMVIAALTNNDNELRKAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLRNAPDWVADWTGFRPDSAPPLEGGERIIQ
WWREKGKDPREKLLIFSDALDIDTIEKTYHHFHGKVRMSFGWGTDLTNDFVGCSPQETATFDALSLVCKVTHANGRPAVK
LSDNPEKTIGNPQEIQRYLNFFGNENRVAKPIKT

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=405, Percent_Identity=33.5802469135802, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324783, Length=429, Percent_Identity=31.2354312354312, Blast_Score=164, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_BARHE (Q6G5H6)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_032954.1
- HSSP:   Q8UIS9
- ProteinModelPortal:   Q6G5H6
- SMR:   Q6G5H6
- GeneID:   2865455
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH00910
- NMPDR:   fig|283166.1.peg.82
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- PhylomeDB:   Q6G5H6
- ProtClustDB:   PRK05321
- BioCyc:   BHEN283166:BH00910-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 50421; Mature: 50421

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPNVNVTFSLINRSKTIRL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEE
ADDIDEMELRAQLDHALNLRFTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELT
CCCHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCHHCCCHHHHHHHHHCCCCCEEEE
RKDGQYILHFHGPWTHSSMWEIPALSIISELRSRAAMKKLDRFTLDVLYARAKAKMWSKV
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKKLPNIKISDFGTRRRHSFLWQRWCVEALKEGIGNSFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVIAALTNNDNELRKAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLRNAPDWVAD
CHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCHHHHH
WTGFRPDSAPPLEGGERIIQWWREKGKDPREKLLIFSDALDIDTIEKTYHHFHGKVRMSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHHCCEEEEEE
GWGTDLTNDFVGCSPQETATFDALSLVCKVTHANGRPAVKLSDNPEKTIGNPQEIQRYLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEECCCCHHHCCCHHHHHHHHH
FFGNENRVAKPIKT
HHCCCCCCCCCCCC
>Mature Secondary Structure
MNHPDIARRVYNHTWKLDPIIRSLLDTDFYKLLMVQMIWGLYPNVNVTFSLINRSKTIRL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEE
ADDIDEMELRAQLDHALNLRFTKKEMIWLAGNTFYGRKQIFEPDFLQWLENFQLPEYELT
CCCHHHHHHHHHHHHHHCCEEECCEEEEEECCCCCCCHHCCCHHHHHHHHHCCCCCEEEE
RKDGQYILHFHGPWTHSSMWEIPALSIISELRSRAAMKKLDRFTLDVLYARAKAKMWSKV
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKKLPNIKISDFGTRRRHSFLWQRWCVEALKEGIGNSFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVIAALTNNDNELRKAPYQVLQDWNRYYGGNLLIVLPDTFGTEAFLRNAPDWVAD
CHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHCCCHHHHH
WTGFRPDSAPPLEGGERIIQWWREKGKDPREKLLIFSDALDIDTIEKTYHHFHGKVRMSF
CCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHEEEEECCCCHHHHHHHHHHHCCEEEEEE
GWGTDLTNDFVGCSPQETATFDALSLVCKVTHANGRPAVKLSDNPEKTIGNPQEIQRYLN
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCCCCEEEECCCCHHHCCCHHHHHHHHH
FFGNENRVAKPIKT
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA