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The map label for this gene is trxA [C]

Identifier: 49474855

GI number: 49474855

Start: 27517

End: 27840

Strand: Reverse

Name: trxA [C]

Synonym: BH00260

Alternate gene names: 49474855

Gene position: 27840-27517 (Counterclockwise)

Preceding gene: 49474856

Following gene: 49474852

Centisome position: 1.44

GC content: 37.35

Gene sequence:

>324_bases
ATGAGCTGTATAAAAGTTGATAAGAGCAATTTTGAAAGTGAAGTTTTGACTTCTTCTACCCCTGTTGTGGTTGATTTTTG
GGCAGAATGGTGTGGTCCTTGTAAAATGATTGCTCCGATTTTAGATGAAATTTCAATGGAAATGCAAAATCAAGTCAAAA
TTGCCAAAGTGAATATTGATGAAAATCCGGAACTGGCTACCCAATATGGAGTGCGCTCAATTCCTACCTTATTGATGTTC
AAAGATGGAAATATTGCATCAAATATGGTTGGCGCTGCTTCTAAAGGACGTGTTTCTGAATGGATTAAAGAGGGGCTTCG
TTAA

Upstream 100 bases:

>100_bases
CTTGATAAGCTGAGAAAAGCTTTTTCTATTTATCTTTGCAATAACTTGATATGAAGCGTTATCGTACCAATCTATAGAAA
TGAGTATAAAGGATAAATCA

Downstream 100 bases:

>100_bases
GCTCGCTCATAGTGATTTTTCTAAAAAGGAGAGAGGTTTTGCCTCTCCTCCTTGCTTGCTCTTTATTCAAGACAATTTTT
TCACAAAAAAGATATCTGTT

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MSCIKVDKSNFESEVLTSSTPVVVDFWAEWCGPCKMIAPILDEISMEMQNQVKIAKVNIDENPELATQYGVRSIPTLLMF
KDGNIASNMVGAASKGRVSEWIKEGLR

Sequences:

>Translated_107_residues
MSCIKVDKSNFESEVLTSSTPVVVDFWAEWCGPCKMIAPILDEISMEMQNQVKIAKVNIDENPELATQYGVRSIPTLLMF
KDGNIASNMVGAASKGRVSEWIKEGLR
>Mature_106_residues
SCIKVDKSNFESEVLTSSTPVVVDFWAEWCGPCKMIAPILDEISMEMQNQVKIAKVNIDENPELATQYGVRSIPTLLMFK
DGNIASNMVGAASKGRVSEWIKEGLR

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=38.7755102040816, Blast_Score=92, Evalue=7e-20,
Organism=Homo sapiens, GI20070125, Length=83, Percent_Identity=39.7590361445783, Blast_Score=69, Evalue=7e-13,
Organism=Homo sapiens, GI38505222, Length=82, Percent_Identity=36.5853658536585, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=53.3980582524272, Blast_Score=129, Evalue=3e-32,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=40.4255319148936, Blast_Score=97, Evalue=2e-22,
Organism=Escherichia coli, GI87081747, Length=92, Percent_Identity=31.5217391304348, Blast_Score=62, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=40.2061855670103, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509965, Length=89, Percent_Identity=33.7078651685393, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=40.2777777777778, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=100, Percent_Identity=37, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=40.2777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=40.2777777777778, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=90, Percent_Identity=32.2222222222222, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=75, Percent_Identity=40, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=88, Percent_Identity=35.2272727272727, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=83, Percent_Identity=33.7349397590361, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=91, Percent_Identity=31.8681318681319, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=91, Percent_Identity=36.2637362637363, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=44.047619047619, Blast_Score=74, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=39.2857142857143, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=71, Percent_Identity=38.0281690140845, Blast_Score=68, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573567, Length=99, Percent_Identity=39.3939393939394, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=45, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17648013, Length=101, Percent_Identity=37.6237623762376, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583090, Length=101, Percent_Identity=37.6237623762376, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21358065, Length=98, Percent_Identity=36.734693877551, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639068, Length=96, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=37.9310344827586, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11868; Mature: 11737

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCIKVDKSNFESEVLTSSTPVVVDFWAEWCGPCKMIAPILDEISMEMQNQVKIAKVNID
CCCCCCCCCCCCHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCC
ENPELATQYGVRSIPTLLMFKDGNIASNMVGAASKGRVSEWIKEGLR
CCCCHHHHHCHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SCIKVDKSNFESEVLTSSTPVVVDFWAEWCGPCKMIAPILDEISMEMQNQVKIAKVNID
CCCCCCCCCCCHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCC
ENPELATQYGVRSIPTLLMFKDGNIASNMVGAASKGRVSEWIKEGLR
CCCCHHHHHCHHCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]