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The map label for this gene is ykoH [H]

Identifier: 49186005

GI number: 49186005

Start: 2975310

End: 2976683

Strand: Direct

Name: ykoH [H]

Synonym: BAS3000

Alternate gene names: 49186005

Gene position: 2975310-2976683 (Clockwise)

Preceding gene: 49186004

Following gene: 49186008

Centisome position: 56.9

GC content: 35.3

Gene sequence:

>1374_bases
ATGAAAAGACTATCAATAAAAATGAGAGTAACCCTGTGGTATACGGGGCTAATTGTAATTATTATGGCACTCGTGTTAGC
TTTTATTTTAACTTCTTCAGATAAAGTTTTGCTTTTTAATATGAAAAATCAATTGAAGAGCACAGTAAAAGAAAGCGTTG
AAGATATCGAGTATAAGCATGGGCAATTAAAGATGGACGATGATTTTGAAACCTTTGAAGATGGAGTAAATATCATCATT
TATAATAAACAAAGTGAGCTGCTGGCAGGTAATAGTCCAACAAGCTTTAATAAAAAGATATCGCTTAAATCCGATGAAAT
ACAAATTATTAAAGACGGTAATAAAGAATGGATCGTATATGATTTTCTCCATAATGCAGACGGCGGTGAGCAAGTCTGGG
TGCGTGGAATAATGACGATGAGCCGATTATCATCAACGATGAATACACTTATCGTATTAACACTGATCTCATTTCCATTA
CTTATTCTCATTGCGGCAGTGGGAGGATATTTTATTACGCAAAGAGCGTTTCGACCTGTGCAGCAAATGAGTGATTCAGC
CAGTAAAATTGGTGATGGTAAAGACCTTTCGAAGAGAATTAATTTAAAAGGTTCACCGAAAGACGAAATGTATCATTTAG
CACAAACTTTTGACAAAATGTTTGAGCGATTGGAGACATCATTTGAAAGTGAAAAACAATTTACATCTGACGCATCTCAT
GAATTAAGAACACCAACATCTGTTATTATTTCGCAATGCGAATACGCTTTATCCCAGAGAAATAATCCGAAAGAAATGGA
AGAATCGTTAGAAGTAATTTTAAAGCAATCACGTAAAATGTCCGCGCTAATCTCACAACTCTTATTATTAGCAAGAGCTG
ACCAAGGAAATGATAATACTTTCCAATTTGAATGTATCAATATGAGTGAATTAACGGAAATCGTTGTAGAAGAACTTTCA
TTAATGGTTCAAGAAGCTTCGATTGATATAACAACTCATATAGAGGAAGACCTGTTTATAAAAGCAGATCAAACATTGAT
GATGCGTTTATTAATGAATTTATTAACGAATGCGATTGCTTATAGCAAAGCGAACGGAACTGTTCATATGCAACTGTTCC
GTGACGAAACCAACATAATAGGTAAAGTCTCCGATAATGGCATAGGCATCAGTGAGCAACATATTACGAAAATTTGGGAC
CGCTTCTATCGAGTTGACGCAGCACGAACATCTTCAAACATTGGAAATACAGGTTTAGGATTGTCGATGGTAAAATGGAT
TGTCGAACTGCACGGAGGAGAAATAACAGTTGAAAGTGGATTAGGAGAAGGCAGTACTTTTACCTTTAAACTACCAATTG
AAAAACAAGCATAG

Upstream 100 bases:

>100_bases
ATGTTTACGTCCGCTATCTTCGAAAAAAAGTTGATAGCCAGTTTGAAACGAAGTTAATTCATACAGTAAGAGGAACTGGT
TACGTATTGCGAGTAGAATC

Downstream 100 bases:

>100_bases
TTGATGAGCGGCTGTAGCTTCAGAATAAAGATCTCTCTTCCCCCTTATATAAAAGTAATTGACGTATTTTAAACATCATT
GATGAACAGGGTAAAATACG

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKRLSIKMRVTLWYTGLIVIIMALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIII
YNKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSRLSSTMNTLIVLTLISFPL
LILIAAVGGYFITQRAFRPVQQMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASH
ELRTPTSVIISQCEYALSQRNNPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELS
LMVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWD
RFYRVDAARTSSNIGNTGLGLSMVKWIVELHGGEITVESGLGEGSTFTFKLPIEKQA

Sequences:

>Translated_457_residues
MKRLSIKMRVTLWYTGLIVIIMALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIII
YNKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSRLSSTMNTLIVLTLISFPL
LILIAAVGGYFITQRAFRPVQQMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASH
ELRTPTSVIISQCEYALSQRNNPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELS
LMVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWD
RFYRVDAARTSSNIGNTGLGLSMVKWIVELHGGEITVESGLGEGSTFTFKLPIEKQA
>Mature_457_residues
MKRLSIKMRVTLWYTGLIVIIMALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKHGQLKMDDDFETFEDGVNIII
YNKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVYDFLHNADGGEQVWVRGIMTMSRLSSTMNTLIVLTLISFPL
LILIAAVGGYFITQRAFRPVQQMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASH
ELRTPTSVIISQCEYALSQRNNPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNTFQFECINMSELTEIVVEELS
LMVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIAYSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWD
RFYRVDAARTSSNIGNTGLGLSMVKWIVELHGGEITVESGLGEGSTFTFKLPIEKQA

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=29.0849673202614, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1788279, Length=320, Percent_Identity=28.125, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=25.6317689530686, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789403, Length=476, Percent_Identity=25.6302521008403, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=26.6903914590747, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=31.2757201646091, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790861, Length=309, Percent_Identity=26.537216828479, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1787894, Length=305, Percent_Identity=26.5573770491803, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=25.1028806584362, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=30.9090909090909, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=24.1610738255034, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=236, Percent_Identity=29.2372881355932, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=27.1111111111111, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=26.9387755102041, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25.4237288135593, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=24.3589743589744, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789808, Length=492, Percent_Identity=22.9674796747967, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51635; Mature: 51635

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSIKMRVTLWYTGLIVIIMALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKH
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
GQLKMDDDFETFEDGVNIIIYNKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVY
CCEEECCCHHHHHCCCEEEEECCCCCEECCCCCCCCCCEEEECCCCEEEEECCCCCEEEE
DFLHNADGGEQVWVRGIMTMSRLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASH
HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ELRTPTSVIISQCEYALSQRNNPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNT
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
FQFECINMSELTEIVVEELSLMVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIA
EEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
YSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLG
EECCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LSMVKWIVELHGGEITVESGLGEGSTFTFKLPIEKQA
HHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MKRLSIKMRVTLWYTGLIVIIMALVLAFILTSSDKVLLFNMKNQLKSTVKESVEDIEYKH
CCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
GQLKMDDDFETFEDGVNIIIYNKQSELLAGNSPTSFNKKISLKSDEIQIIKDGNKEWIVY
CCEEECCCHHHHHCCCEEEEECCCCCEECCCCCCCCCCEEEECCCCEEEEECCCCCEEEE
DFLHNADGGEQVWVRGIMTMSRLSSTMNTLIVLTLISFPLLILIAAVGGYFITQRAFRPV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQMSDSASKIGDGKDLSKRINLKGSPKDEMYHLAQTFDKMFERLETSFESEKQFTSDASH
HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ELRTPTSVIISQCEYALSQRNNPKEMEESLEVILKQSRKMSALISQLLLLARADQGNDNT
HHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
FQFECINMSELTEIVVEELSLMVQEASIDITTHIEEDLFIKADQTLMMRLLMNLLTNAIA
EEEEEECHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
YSKANGTVHMQLFRDETNIIGKVSDNGIGISEQHITKIWDRFYRVDAARTSSNIGNTGLG
EECCCCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
LSMVKWIVELHGGEITVESGLGEGSTFTFKLPIEKQA
HHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]