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The map label for this gene is pcoR [H]

Identifier: 49186004

GI number: 49186004

Start: 2974639

End: 2975313

Strand: Direct

Name: pcoR [H]

Synonym: BAS2999

Alternate gene names: 49186004

Gene position: 2974639-2975313 (Clockwise)

Preceding gene: 49186000

Following gene: 49186005

Centisome position: 56.89

GC content: 36.0

Gene sequence:

>675_bases
ATGCGAGTTCTTATTGTCGAAGATGAACAAGACTTACAAAATATATTAGTAAAGCGATTAAATGCAGAACATTATAGTGT
CGATGCATGCGGGAATGGAGAAGATGCCTTAGATTATATAAACATGGCTACCTACGATTTGATCGTGCTTGACATTATGA
TTCCCGGAATAAATGGTTTACAAGTATTACAAAAATTACGCGCGGACAATCATACAACTTCTGTCTTGCTTCTTACAGCT
AAAGATACAATTGATGATCGCGTAAAAGGACTCGACTTAGGTGCGGACGATTATTTAGTAAAGCCGTTCGCTTTTGACGA
ACTGCTAGCAAGAATTCGAGTGTTAATGCGAAGAAAAACAGGAAATACATCTAATGTGTTTGAAATTGCTGACCTAGTGG
TGGATTGCAATATGCATAAAGTAACAAGAGGAGACCAAGTTATTACTCTTTCCAGTAAAGAATTTGCTATTTTAGAATAT
ATGATTCGTAATAAAGAAGTTGTGTTGACACGAGATAAAATTGAGCAACATGTGTGGAATTACGACTATGAAGGTGGCTC
AAATATTATTGATGTTTACGTCCGCTATCTTCGAAAAAAAGTTGATAGCCAGTTTGAAACGAAGTTAATTCATACAGTAA
GAGGAACTGGTTACGTATTGCGAGTAGAATCATGA

Upstream 100 bases:

>100_bases
GTACAAAAAATAAAATGATATAATTAAATCGTTTCTAATCTCTCTTTAATGTTTTGGAATTATAGTGATACATATAAATA
AGGAAAAAAGGAGAATGTTA

Downstream 100 bases:

>100_bases
AAAGACTATCAATAAAAATGAGAGTAACCCTGTGGTATACGGGGCTAATTGTAATTATTATGGCACTCGTGTTAGCTTTT
ATTTTAACTTCTTCAGATAA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINMATYDLIVLDIMIPGINGLQVLQKLRADNHTTSVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKVDSQFETKLIHTVRGTGYVLRVES

Sequences:

>Translated_224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINMATYDLIVLDIMIPGINGLQVLQKLRADNHTTSVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKVDSQFETKLIHTVRGTGYVLRVES
>Mature_224_residues
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINMATYDLIVLDIMIPGINGLQVLQKLRADNHTTSVLLLTA
KDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKTGNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEY
MIRNKEVVLTRDKIEQHVWNYDYEGGSNIIDVYVRYLRKKVDSQFETKLIHTVRGTGYVLRVES

Specific function: Probable member of a two-component regulatory system pcoS/pcoR. May be involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box) [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=49.1071428571429, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=43.1192660550459, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.0909090909091, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.0909090909091, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=36.3636363636364, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.7837837837838, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=31.981981981982, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.2217194570136, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786911, Length=217, Percent_Identity=31.7972350230415, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=32.8947368421053, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=29.2035398230088, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.0748898678414, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=26.8398268398268, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=35.6435643564356, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=32.4074074074074, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=108, Percent_Identity=33.3333333333333, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25654; Mature: 25654

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINMATYDLIVLDIMIPGINGL
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEHHCCCCCHH
QVLQKLRADNHTTSVLLLTAKDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKT
HHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEYMIRNKEVVLTRDKIEQHVWN
CCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHCC
YDYEGGSNIIDVYVRYLRKKVDSQFETKLIHTVRGTGYVLRVES
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MRVLIVEDEQDLQNILVKRLNAEHYSVDACGNGEDALDYINMATYDLIVLDIMIPGINGL
CEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEHHCCCCCHH
QVLQKLRADNHTTSVLLLTAKDTIDDRVKGLDLGADDYLVKPFAFDELLARIRVLMRRKT
HHHHHHHCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHCC
GNTSNVFEIADLVVDCNMHKVTRGDQVITLSSKEFAILEYMIRNKEVVLTRDKIEQHVWN
CCCCHHHHHHHHHHCCCCCEECCCCEEEEECCCCHHHHHHHHCCCEEEEEHHHHHHHHCC
YDYEGGSNIIDVYVRYLRKKVDSQFETKLIHTVRGTGYVLRVES
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8594334; 9141682 [H]