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The map label for this gene is adhB [H]

Identifier: 49185918

GI number: 49185918

Start: 2878711

End: 2879844

Strand: Direct

Name: adhB [H]

Synonym: BAS2912

Alternate gene names: 49185918

Gene position: 2878711-2879844 (Clockwise)

Preceding gene: 49185915

Following gene: 49185920

Centisome position: 55.06

GC content: 36.51

Gene sequence:

>1134_bases
ATGAAAGCTGTAACCTATCAAGGACCAAACCAAGTACAGGTTAAACAAGTGGATGATGCAAAGTTAGAGAAAAAAGATGA
TATTATTGTAAAGATTACTTCAACTGCTATTTGCGGTTCTGATTTACATTTATATCAAGGGAACATGCCTTTACCTCAAG
GATACATTATTGGCCATGAGCCAATGGGAATTGTTGAAGAAGTGGGCCCAGATGTTACTAAAGTGAAAAAAGGAGATCGT
GTTGTTATCCCCTTTAATGTTGCTTGTGGACATTGTTTTTATTGCCAACACGAAATGGAAAGTCAATGTGATAACTCGAA
CCCTCATTACGATTCTGGTGGATACTTTGGTTATACAGAGAAATTTGGTAACCATCCGGGCGGACAAGTTGAATATTTAA
AAGTTCCTTTTGGAAATTTCACTCCATTTGTTATACCGGAATCATGCGAACTTGAAGATGAATCCCTACTCTTTTTATCG
GATGTTTTGCCAACAGCCTATTGGAGTGTAATAAATGCAGGTGTTAAACCAGGTGATACTGTTATTGTCCTTGGTTGTGG
ACCTGTTGGATTAATGACACAAAAATTCGCTTGGATGCATGGTGCTAAACGCGTAATCGCAGTCGATTACTTAGATTATC
GAATAAATTATGCAAAAAAGATTAACAATGTTGAGGTATTTGAATTTACAAAATTTCCTGATATGGGAGAACATTTAAAA
GAAATCACACATGGCGGTGCGGATGTAGTCATTGATTGCGTGGGCATGGATGGTAAAAAATCGCCCCTAGAATTTCTGGA
ACAAAAATTAAAACTACAAGGTGGTACCCTCGGTCCTATTCAAATTGCTACGAAAGCCGTAAGAAAATATGGAACAGTTC
AAATGACTGGTGTTTATGGTGGTAATTATAATGCATTTCCACTCGGAGCATTTTGGGTTAGAAATATTAATCTGAAAATG
GGACAAGCACCTGTCATTCATTTTATGCCGGAACTATTTGAAAAAATAACAAACAAAGAATTCGATCCAAAAGAGATTAT
TACACACAAAATCCCCCTTGAAGAAGCAAGCTATGGTTATCAAATTTTTAATAACCGGGAAGATGATTGTATAAAAGTCA
TTTTGAAGCCTTGA

Upstream 100 bases:

>100_bases
TCATAACAACACTATGTATAGATTTCTCTTTACTAAAGATTTCCGTTTTGCCAAGAGATACATATAAATTATGAAAAATG
ATTCCTAAAGGAGATATGAG

Downstream 100 bases:

>100_bases
AAATACATCCTTTTTAAATGATTATTTTTAACTATTCTTAAAGCTAAAGATAAGATTAAAATCCATGCCCTTATCTTTTT
CACCCAAAATTAGTAGTTAT

Product: zinc-containing alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKAVTYQGPNQVQVKQVDDAKLEKKDDIIVKITSTAICGSDLHLYQGNMPLPQGYIIGHEPMGIVEEVGPDVTKVKKGDR
VVIPFNVACGHCFYCQHEMESQCDNSNPHYDSGGYFGYTEKFGNHPGGQVEYLKVPFGNFTPFVIPESCELEDESLLFLS
DVLPTAYWSVINAGVKPGDTVIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLK
EITHGGADVVIDCVGMDGKKSPLEFLEQKLKLQGGTLGPIQIATKAVRKYGTVQMTGVYGGNYNAFPLGAFWVRNINLKM
GQAPVIHFMPELFEKITNKEFDPKEIITHKIPLEEASYGYQIFNNREDDCIKVILKP

Sequences:

>Translated_377_residues
MKAVTYQGPNQVQVKQVDDAKLEKKDDIIVKITSTAICGSDLHLYQGNMPLPQGYIIGHEPMGIVEEVGPDVTKVKKGDR
VVIPFNVACGHCFYCQHEMESQCDNSNPHYDSGGYFGYTEKFGNHPGGQVEYLKVPFGNFTPFVIPESCELEDESLLFLS
DVLPTAYWSVINAGVKPGDTVIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLK
EITHGGADVVIDCVGMDGKKSPLEFLEQKLKLQGGTLGPIQIATKAVRKYGTVQMTGVYGGNYNAFPLGAFWVRNINLKM
GQAPVIHFMPELFEKITNKEFDPKEIITHKIPLEEASYGYQIFNNREDDCIKVILKP
>Mature_377_residues
MKAVTYQGPNQVQVKQVDDAKLEKKDDIIVKITSTAICGSDLHLYQGNMPLPQGYIIGHEPMGIVEEVGPDVTKVKKGDR
VVIPFNVACGHCFYCQHEMESQCDNSNPHYDSGGYFGYTEKFGNHPGGQVEYLKVPFGNFTPFVIPESCELEDESLLFLS
DVLPTAYWSVINAGVKPGDTVIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLK
EITHGGADVVIDCVGMDGKKSPLEFLEQKLKLQGGTLGPIQIATKAVRKYGTVQMTGVYGGNYNAFPLGAFWVRNINLKM
GQAPVIHFMPELFEKITNKEFDPKEIITHKIPLEEASYGYQIFNNREDDCIKVILKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=387, Percent_Identity=27.906976744186, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI71565152, Length=379, Percent_Identity=25.3298153034301, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=26.9886363636364, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI4501933, Length=383, Percent_Identity=25.3263707571802, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71565154, Length=385, Percent_Identity=23.3766233766234, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71743840, Length=387, Percent_Identity=26.0981912144703, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073058, Length=387, Percent_Identity=26.0981912144703, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI156523966, Length=372, Percent_Identity=26.0752688172043, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.207756232687, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786825, Length=390, Percent_Identity=43.3333333333333, Blast_Score=311, Evalue=3e-86,
Organism=Escherichia coli, GI87082125, Length=360, Percent_Identity=27.5, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1788073, Length=361, Percent_Identity=26.0387811634349, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=213, Percent_Identity=31.924882629108, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787863, Length=385, Percent_Identity=24.1558441558442, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790718, Length=340, Percent_Identity=24.4117647058824, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI226510992, Length=382, Percent_Identity=25.130890052356, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788407, Length=293, Percent_Identity=27.3037542662116, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786552, Length=393, Percent_Identity=23.4096692111959, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081918, Length=199, Percent_Identity=28.643216080402, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788075, Length=253, Percent_Identity=28.4584980237154, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=374, Percent_Identity=23.5294117647059, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=382, Percent_Identity=23.8219895287958, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=224, Percent_Identity=27.6785714285714, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=23.2984293193717, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=23.5795454545455, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=298, Percent_Identity=27.8523489932886, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320033, Length=392, Percent_Identity=25.765306122449, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=414, Percent_Identity=26.8115942028986, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=27.8551532033426, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=27.5766016713092, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=269, Percent_Identity=27.1375464684015, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=302, Percent_Identity=26.158940397351, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=247, Percent_Identity=28.7449392712551, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=248, Percent_Identity=26.2096774193548, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=233, Percent_Identity=27.0386266094421, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=283, Percent_Identity=25.0883392226148, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737897, Length=377, Percent_Identity=23.8726790450928, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137530, Length=259, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17737895, Length=395, Percent_Identity=24.0506329113924, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221457811, Length=257, Percent_Identity=26.8482490272374, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45550770, Length=257, Percent_Identity=26.8482490272374, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551930, Length=257, Percent_Identity=26.8482490272374, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1; 1.2.1.1

Molecular weight: Translated: 42058; Mature: 42058

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVTYQGPNQVQVKQVDDAKLEKKDDIIVKITSTAICGSDLHLYQGNMPLPQGYIIGHE
CCEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCCEEEEECCCCCCCCEEECCC
PMGIVEEVGPDVTKVKKGDRVVIPFNVACGHCFYCQHEMESQCDNSNPHYDSGGYFGYTE
CCCHHHHCCCCHHHCCCCCEEEEEEECCCCEEEEECHHHHHHCCCCCCCCCCCCEECCHH
KFGNHPGGQVEYLKVPFGNFTPFVIPESCELEDESLLFLSDVLPTAYWSVINAGVKPGDT
HHCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCE
VIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLK
EEEEECCCHHHHHHHHHHHHCCCEEEEEEEEHHEEEHHHHCCCEEEEEEECCCCHHHHHH
EITHGGADVVIDCVGMDGKKSPLEFLEQKLKLQGGTLGPIQIATKAVRKYGTVQMTGVYG
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEC
GNYNAFPLGAFWVRNINLKMGQAPVIHFMPELFEKITNKEFDPKEIITHKIPLEEASYGY
CCCCCCEEEEEEEEECCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCE
QIFNNREDDCIKVILKP
EEECCCCCCEEEEEECC
>Mature Secondary Structure
MKAVTYQGPNQVQVKQVDDAKLEKKDDIIVKITSTAICGSDLHLYQGNMPLPQGYIIGHE
CCEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCEEECCCEEEEECCCCCCCCEEECCC
PMGIVEEVGPDVTKVKKGDRVVIPFNVACGHCFYCQHEMESQCDNSNPHYDSGGYFGYTE
CCCHHHHCCCCHHHCCCCCEEEEEEECCCCEEEEECHHHHHHCCCCCCCCCCCCEECCHH
KFGNHPGGQVEYLKVPFGNFTPFVIPESCELEDESLLFLSDVLPTAYWSVINAGVKPGDT
HHCCCCCCEEEEEEECCCCCCCEEECCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCE
VIVLGCGPVGLMTQKFAWMHGAKRVIAVDYLDYRINYAKKINNVEVFEFTKFPDMGEHLK
EEEEECCCHHHHHHHHHHHHCCCEEEEEEEEHHEEEHHHHCCCEEEEEEECCCCHHHHHH
EITHGGADVVIDCVGMDGKKSPLEFLEQKLKLQGGTLGPIQIATKAVRKYGTVQMTGVYG
HHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEC
GNYNAFPLGAFWVRNINLKMGQAPVIHFMPELFEKITNKEFDPKEIITHKIPLEEASYGY
CCCCCCEEEEEEEEECCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCE
QIFNNREDDCIKVILKP
EEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]