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The map label for this gene is coaW

Identifier: 49185708

GI number: 49185708

Start: 2682499

End: 2683329

Strand: Direct

Name: coaW

Synonym: BAS2702

Alternate gene names: 49185708

Gene position: 2682499-2683329 (Clockwise)

Preceding gene: 49185707

Following gene: 49185716

Centisome position: 51.3

GC content: 31.65

Gene sequence:

>831_bases
ATGGAAAGTACGATCGGTATCGATGCTGGAGGAACATTAACAAAAATTGCTTATTTGAATAAAAAAATGCAATTAGCTTT
TGAAAAAGTTTATTCAAATGAACAAAATAAAATAATAGATTGGCTTAAGAACCAAACTGGTATAAAACAAATATGTATTA
CTGGTGGTAAAGCGAAACAATTACAACAACTACTTTCAGCCTCATATAAAATAGTGGAACTAAATGAATTTGAAGCTACT
CTTGTAGGTGTCCGTTACATATTAAAAAAAGAAAAATATGATATAAACAACTTTGTTTTAACAAATATCGGTACAGGTAC
TTCCATTCATTACATTTATAATGACCAATATATTCGCGCTGGTGGAACCGGTGTTGGCGGTGGTACTATTATGGGGCTTT
CAAAATTGTTAACAAATATAGATCATTTTGAAGATGTGATTCCTTTAACAAAAGTAGGATCTAGAAAAGAACTTGATATT
ACGGTTGGAGATATTTATGGTGGTATTCTCTCTCCTATTGATAATAGTTTAACTGCAAGCAATTTTGGTAAAGCCGCTAT
TACAGACTCAAATTATAATAGCTCAGATATACTTGCTACTATACAAGGACTTGTCGGTGAAGTCGTTACTGCATTAAGCC
TTCAATTCGCCGAAACAAAAAACATTGACCATATTATTTATATTGGTTCGACTCTATGTAATAACATACATCTTCAAAAT
ATTATTAGTAGTTACACAAAATACCAAAATAAAACACCCATCTTTTTACGAGATGGTGGTAATAGCGGTGCGATTGGTGC
TTTACTTTATGCTACGAATAAAAAAAGCTGA

Upstream 100 bases:

>100_bases
CAGAATAGAGACGTTTTCATTCACTAGGGTATCTATCTCCTACAAATTCGTCTCATCAACATGAACAGAGTAAACAAATT
ATTTAGTTAGGGGCAGAAAA

Downstream 100 bases:

>100_bases
CTTTTGTCAGCTTTTTGAAATGCGGATTTTATACGCTAAAACAGTCTTTAAATGTGGAATTTTATCTTTGTTACTTTAAA
AATCAACTAGTTCCCCAGCC

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-II; Pantothenic acid kinase

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MESTIGIDAGGTLTKIAYLNKKMQLAFEKVYSNEQNKIIDWLKNQTGIKQICITGGKAKQLQQLLSASYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYIYNDQYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKAAITDSNYNSSDILATIQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS

Sequences:

>Translated_276_residues
MESTIGIDAGGTLTKIAYLNKKMQLAFEKVYSNEQNKIIDWLKNQTGIKQICITGGKAKQLQQLLSASYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYIYNDQYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKAAITDSNYNSSDILATIQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
>Mature_276_residues
MESTIGIDAGGTLTKIAYLNKKMQLAFEKVYSNEQNKIIDWLKNQTGIKQICITGGKAKQLQQLLSASYKIVELNEFEAT
LVGVRYILKKEKYDINNFVLTNIGTGTSIHYIYNDQYIRAGGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDI
TVGDIYGGILSPIDNSLTASNFGKAAITDSNYNSSDILATIQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG5146

COG function: function code H; Pantothenate kinase, acetyl-CoA regulated

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II pantothenate kinase family

Homologues:

Organism=Homo sapiens, GI8922665, Length=330, Percent_Identity=25.1515151515152, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI23510402, Length=259, Percent_Identity=27.4131274131274, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI23510400, Length=300, Percent_Identity=26.3333333333333, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI24430175, Length=259, Percent_Identity=27.4131274131274, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI24430167, Length=259, Percent_Identity=27.4131274131274, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI85838513, Length=259, Percent_Identity=27.4131274131274, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI13375789, Length=262, Percent_Identity=25.5725190839695, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32565377, Length=330, Percent_Identity=23.9393939393939, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI25144310, Length=330, Percent_Identity=23.9393939393939, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144312, Length=219, Percent_Identity=27.3972602739726, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20544160, Length=268, Percent_Identity=30.2238805970149, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17864532, Length=268, Percent_Identity=30.2238805970149, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667450, Length=268, Percent_Identity=30.2238805970149, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667454, Length=268, Percent_Identity=30.2238805970149, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20544156, Length=268, Percent_Identity=30.2238805970149, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAW_BACAN (Q81PB2)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017225
- EMBL:   AE017334
- RefSeq:   NP_845240.1
- RefSeq:   YP_019543.1
- RefSeq:   YP_028960.1
- EnsemblBacteria:   EBBACT00000010451
- EnsemblBacteria:   EBBACT00000017615
- EnsemblBacteria:   EBBACT00000022881
- GeneID:   1088439
- GeneID:   2815120
- GeneID:   2850715
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_2901
- KEGG:   bar:GBAA_2901
- KEGG:   bat:BAS2702
- TIGR:   BA_2901
- TIGR:   GBAA_2901
- GeneTree:   EBGT00050000004046
- HOGENOM:   HBG339744
- OMA:   LTASNFG
- ProtClustDB:   PRK13317
- BioCyc:   BANT260799:BAS2702-MONOMER
- BioCyc:   BANT261594:GBAA2901-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01273
- InterPro:   IPR011602
- InterPro:   IPR014642
- InterPro:   IPR004567
- PANTHER:   PTHR12280:SF4
- TIGRFAMs:   TIGR00555

Pfam domain/function: PF03630 Fumble

EC number: =2.7.1.33

Molecular weight: Translated: 30061; Mature: 30061

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 76-76 BINDING 105-105 BINDING 143-143 BINDING 230-230

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTIGIDAGGTLTKIAYLNKKMQLAFEKVYSNEQNKIIDWLKNQTGIKQICITGGKAKQ
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCHHH
LQQLLSASYKIVELNEFEATLVGVRYILKKEKYDINNFVLTNIGTGTSIHYIYNDQYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCEEEC
GGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
NFGKAAITDSNYNSSDILATIQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MESTIGIDAGGTLTKIAYLNKKMQLAFEKVYSNEQNKIIDWLKNQTGIKQICITGGKAKQ
CCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCHHH
LQQLLSASYKIVELNEFEATLVGVRYILKKEKYDINNFVLTNIGTGTSIHYIYNDQYIRA
HHHHHHCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCEEEC
GGTGVGGGTIMGLSKLLTNIDHFEDVIPLTKVGSRKELDITVGDIYGGILSPIDNSLTAS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEEEEEHHHHHHHHHHCCCCCCCC
NFGKAAITDSNYNSSDILATIQGLVGEVVTALSLQFAETKNIDHIIYIGSTLCNNIHLQN
CCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHHHHH
IISSYTKYQNKTPIFLRDGGNSGAIGALLYATNKKS
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629