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The map label for this gene is comEC [H]

Identifier: 49185620

GI number: 49185620

Start: 2601375

End: 2602760

Strand: Direct

Name: comEC [H]

Synonym: BAS2613

Alternate gene names: 49185620

Gene position: 2601375-2602760 (Clockwise)

Preceding gene: 49185610

Following gene: 49185621

Centisome position: 49.75

GC content: 34.92

Gene sequence:

>1386_bases
TTGAAAAAGTTTAGTTTATTATTAACAGCATTTGTCATGATTTTAACATTGTTCATTCCAAATCTTACAAGTGCTAAATC
TTTCCCTGATGTCCAATCTAATCATTGGGCAATTAAAGAAATTAACTATTTATCGGATAAAGGTATCATTAATGGTACAC
CAGAAGGAACTTTTAAACCGAGTGATTATGTAACTCGTGGACAAATGGCCTTAATGCTAGATTTATCATTAAAATTAGAA
AAACCATCTAACTATAATCATATTTTTTCCGATGTAGCCAAAGGTGTCTATTACTATGATTCTGTACATAAGTTAGCACA
TAACAATATTGTACAACGTGAAACAAACTACTTCCCTGACCGCTCATTAACTCGTGCAGAAATGGCAGTAGTACTAGTTA
AAACTTTTAATTTGAAACCTACAGGTGCTGACGTCAATTTCCCTGATGTTCCATCTAATCATTGGGGTTACAATTATGTC
AAAATTTTAGCTCAAAATAATATTACAGCTGGATTTCCTGATGGTACATTTGGTCCAGACGTAAAAGTAACTCGTGAACA
GTTCGCTGCATTCTTAGCAAGAGTATTAGAACCAAGTTTCCGTCCAGGTCTTCCTAAGCCTAAAGGAGAGTTAGAAGTCC
ATTATATAAATGTCGAACAAGGTGATGCTACATTTATTAAATCTCCAAGTGGAGAAACGATCCTTATTGATGGCGGAAAT
AACGGAAAAGGTAAAGTTGTAGCAAATTATTTAAAAGGATTAGGATTCCAAACTATCGATTATATGATTGCCACTCATCC
TGATGCCGATCATGTAGGCGGATTGGATGAAGTACTTTATGCTATAAATGTAAAAAACGTTTACGCACCTAAAGTAAGTC
ATACGACACAAACGTTTAAGGACTTTTTAACTGCAGTAGCTAACAAAGGATTGACTATTAAAGAAGCGAAATCTGGAGTA
ACTTTACCAATCAATGGTTTAAACTCACAATTTTTAGCTCCTGTTAAAGAATACGGTAACGATCTAAATGAGTGGAGTGC
TGTATTAAAAGTAACACATGGCAGCAAATCTTTCTTATTTACTGGTGATGCTGAATCTAAAAGTGAAAAAGATATGGTTG
CAACGTATGGTTCCGGCCTAAAATCCGATGTATTAAAACCTGGACATCACGGAAGTAAGACATCTTCTTCTCAGCCATTT
TTAGATGCAGTGAAACCAAGTATCGCTATAATCAGTGCAGGTGCAGGTAACCGATATGGCCATCCTACTCAGGAAACTTT
AGCAAAGTTAAATGCAATGTCTGTTAAGGTATATAGAACTGATTTAAATGGAACTGTAATTATTAATAGTGATGGTTCTA
ACATTTCTGTAAGAGCGGAGAGATAA

Upstream 100 bases:

>100_bases
TACAAAACAATTAATAAAATATTTACCTATTAAACTTTGAATCACTTGTAAGAAATGATAAAGTTAATAAGGTAAAAAAT
ACATCAAGTGAGGCGATTTT

Downstream 100 bases:

>100_bases
TTATGAAGAGAGGTATTATTGACCGTTTTGAAGGCGAACTAGCAGTTATTGAAGTGAATAACGTAACAATTGATGTACCT
AAATCCAAACTCCCTTCCAC

Product: S-layer protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQSNHWAIKEINYLSDKGIINGTPEGTFKPSDYVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVEQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAINVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAIISAGAGNRYGHPTQETLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRAER

Sequences:

>Translated_461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQSNHWAIKEINYLSDKGIINGTPEGTFKPSDYVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVEQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAINVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAIISAGAGNRYGHPTQETLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRAER
>Mature_461_residues
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQSNHWAIKEINYLSDKGIINGTPEGTFKPSDYVTRGQMALMLDLSLKLE
KPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPDRSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYV
KILAQNNITAGFPDGTFGPDVKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVEQGDATFIKSPSGETILIDGGN
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAINVKNVYAPKVSHTTQTFKDFLTAVANKGLTIKEAKSGV
TLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLFTGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPF
LDAVKPSIAIISAGAGNRYGHPTQETLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRAER

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=265, Percent_Identity=25.6603773584906, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 50386; Mature: 50386

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS01072 SLH_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQSNHWAIKEINYLSDKGIINGTPEGTFKP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
SDYVTRGQMALMLDLSLKLEKPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPD
CCCEECCCEEEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC
RSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYVKILAQNNITAGFPDGTFGPD
CCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCC
VKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVEQGDATFIKSPSGETILIDGGN
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCEEEEECCC
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAINVKNVYAPKVSHTTQTFK
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHCCCHHHHHEEEECCCEECCCCCHHHHHHH
DFLTAVANKGLTIKEAKSGVTLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLF
HHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHCCCHHHHEEEEEEECCCCEEEE
TGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPFLDAVKPSIAIISAGAGNRYG
ECCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
HPTQETLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRAER
CCHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECC
>Mature Secondary Structure
MKKFSLLLTAFVMILTLFIPNLTSAKSFPDVQSNHWAIKEINYLSDKGIINGTPEGTFKP
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
SDYVTRGQMALMLDLSLKLEKPSNYNHIFSDVAKGVYYYDSVHKLAHNNIVQRETNYFPD
CCCEECCCEEEEEEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCCCCC
RSLTRAEMAVVLVKTFNLKPTGADVNFPDVPSNHWGYNYVKILAQNNITAGFPDGTFGPD
CCCCHHHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCEECCCCCCCCCC
VKVTREQFAAFLARVLEPSFRPGLPKPKGELEVHYINVEQGDATFIKSPSGETILIDGGN
CEEHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCEEEEECCC
NGKGKVVANYLKGLGFQTIDYMIATHPDADHVGGLDEVLYAINVKNVYAPKVSHTTQTFK
CCCCHHHHHHHHCCCCCEEEEEEEECCCCHHCCCHHHHHEEEECCCEECCCCCHHHHHHH
DFLTAVANKGLTIKEAKSGVTLPINGLNSQFLAPVKEYGNDLNEWSAVLKVTHGSKSFLF
HHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHCCCHHHHEEEEEEECCCCEEEE
TGDAESKSEKDMVATYGSGLKSDVLKPGHHGSKTSSSQPFLDAVKPSIAIISAGAGNRYG
ECCCCCCCCCCHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHCCCCEEEEECCCCCCCC
HPTQETLAKLNAMSVKVYRTDLNGTVIINSDGSNISVRAER
CCHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]