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The map label for this gene is acsA [H]

Identifier: 49185384

GI number: 49185384

Start: 2376487

End: 2378427

Strand: Direct

Name: acsA [H]

Synonym: BAS2376

Alternate gene names: 49185384

Gene position: 2376487-2378427 (Clockwise)

Preceding gene: 49185383

Following gene: 49185385

Centisome position: 45.45

GC content: 38.74

Gene sequence:

>1941_bases
TTGAAACAAGCAGTTTGGTTTCCAACAGAAGAGTATAAAGAAAAAACACGCTTATATGGTTGGATGAAATCATTGGGGTA
TGAAGATTATGAAACGTTTTATAATAAATCTATTGAAGAAACAGCTTGGTTTTGGGGAGAAGCTGAGAAAGTGGTTGGCT
ATCAATGGATGAAACCTTATACAGAAGTGTTAGACCTGCAAAATGGTACACCGTTTGCACAGTGGTATAATGGCGGAACA
TGTAACGTTGTAGAATCAGTTTTATCACGCTGGCTTGCAGATGATGAAACAAGAACGCAACCAGCACTTCAGTATGAAGG
AGAAAATGGAACTTCAAAATCATTTACATATGAAGAACTTGATAGCTGGGTAAGTCGCGCTGCAAATGGTTTGAAACATG
CGGGTATTGAAAAAGGCGACCGAGTAACAATTTATATGCCAATGATTCCAGAAACAGTTGTTGCGATGCTAGCTGTAATG
AAAATCGGAGCAATTATTTCACCAATATTCTCAGGATTTGCGTCTGATGCAGTCATGACACGCGTGCAAGCAGCAGGATC
AAAGATGATCATTACTGCAGATGGTTTTTCACGCCGAGGTAAGATTGTTTCATTAAAAGATGAAGTAGATAAAGCTTGTG
AGCATTGTCCAACTGTTGAAAAAGTCGTTATCGTGCGCCACGCAGGAAATGATTTTACACCGCATAATTATGATTTCTCA
TGGAGTACGTTAGAAAAAGAAAAGCCATTTGTACATGCTGAAGAAATGCATAGTGACGATCCGTTAATGCTCATTTATAC
ATCAGGTACAACAGGAAAACCGAAAGGGACCGTGCACACTCATGCTGGTTTCCCTTTGAAAGCAGCATTTGATGCAGGGT
TTGGGATGAATATAAAACAAGGCGACCGCGTATTATGGGTAACTGATATGGGCTGGATGATGGGACCATTTTTACTATTT
GGCTCTCTCATTAATGGAGCAACGATGGTTATGTACGAAGGTGTTCCGGATTTCCCAAAAGCAGATCGTTTATGGGAGAC
AGTTGATAAATATGAAATTACACATCTTGGTATATCACCAACATTAATTCGTGCGTTAATGGCAAAAGGTGATGAGTATG
TAAATAAACATTCGCTTAAGAGTTTAGAAGTATTTGCCTCAACAGGCGAGCCTTGGAATCCAGATCCTTGGATGTGGCTA
TTTGAAACAGTTGGAAAAAGTAATGTGCCAATTTGTAACTATTCGGGCGGAACTGAAATTTCTGGTGGGATTTTCGGAAA
TGTCCTTATTAAACCAATTGCACCGATAAGCTTTAACGCTTCTTTACCAGGAATGGCAGCGGTTGTGCTCGATGATCAAG
GTAATCCAATTCGTGATGAAGTTGGAGAATTATGTTTAGAGAAACCTTGGGTTGGTATGACGAAAAGTTTCTGGGAAGAC
GATGAGCGTTATGTGAACACATATTGGTCACGTTTTGAAAATAAATGGGTTCACGGTGACTGGGTGGTTTATGATGGTGA
GCAATATATTATTACAGGGCGCTCAGATGATACGCTAAACATTGCTGGAAAACGCATTGGACCTGCTGAATATGAATCTA
TTCTTGTGAAGCATAATGATGTCATAGAAGCTGCCGCGATTGGTGTACCAGATGATGTAAAAGGTGAAGTTTGTCATTGT
TTTGTAGTATTAAGAGATAATGTAACATTTACAGGAGAATTAAAGAAAGAATTAATGAGTTTAGTAAACTCTCATATTGG
AAAAGCATTATGTCCAAAAGATATTCACGTTGTAGAAGATTTACCGAAAACACGTAATTCTAAAGTAATGCGACGCGTCA
TTAAAGCTGCTTATTTAGGGAAAGAACTAGGTGATTTATCATCACTTGTAAACCCTGAAGTAGTGCCATTTATTCAGGGA
TTGCAGTCTAGTAAATTATAA

Upstream 100 bases:

>100_bases
AGTAAATATCAAGTATTTACGGATCGTAAACATCCTGTTTATCCAGTTTAAAAGCCCTATTTAGGGCTTTCTTGCTCAAA
AAGTTAAGGAGGGGAAAACA

Downstream 100 bases:

>100_bases
AATTAAAGCATGTATAATGTGAACTGACCTCTAACAATTAGAGGTCAGTTTTTATGTATACAGAATAGTTTAGTACATGT
GTTTGTTTTTTCTTTTCTAT

Product: acetoacetyl-CoA synthase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKVVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVPFIQG
LQSSKL

Sequences:

>Translated_646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKVVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVPFIQG
LQSSKL
>Mature_646_residues
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKVVGYQWMKPYTEVLDLQNGTPFAQWYNGGT
CNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEELDSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVM
KIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFS
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
GSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWL
FETVGKSNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHC
FVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVPFIQG
LQSSKL

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=648, Percent_Identity=37.037037037037, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI253970489, Length=661, Percent_Identity=36.3086232980333, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI28416953, Length=628, Percent_Identity=36.624203821656, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI13375727, Length=628, Percent_Identity=28.0254777070064, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI31982927, Length=665, Percent_Identity=27.5187969924812, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI38505220, Length=564, Percent_Identity=27.4822695035461, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI42544132, Length=558, Percent_Identity=26.8817204301075, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI122937307, Length=562, Percent_Identity=26.5124555160142, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI157311624, Length=550, Percent_Identity=27.6363636363636, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI157311622, Length=550, Percent_Identity=27.6363636363636, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI115511026, Length=559, Percent_Identity=26.2969588550984, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI58082049, Length=556, Percent_Identity=27.158273381295, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI42544134, Length=366, Percent_Identity=27.3224043715847, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI187761345, Length=429, Percent_Identity=23.3100233100233, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI187761343, Length=429, Percent_Identity=23.3100233100233, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI195947378, Length=466, Percent_Identity=21.244635193133, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=623, Percent_Identity=38.3627608346709, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786529, Length=624, Percent_Identity=32.5320512820513, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI221142682, Length=530, Percent_Identity=23.2075471698113, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788107, Length=565, Percent_Identity=24.070796460177, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=24.1904761904762, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=651, Percent_Identity=35.0230414746544, Blast_Score=343, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI71982997, Length=657, Percent_Identity=35.1598173515982, Blast_Score=342, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI17569507, Length=636, Percent_Identity=27.0440251572327, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17531443, Length=562, Percent_Identity=24.5551601423488, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994694, Length=477, Percent_Identity=24.9475890985325, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994703, Length=477, Percent_Identity=24.9475890985325, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=477, Percent_Identity=24.9475890985325, Blast_Score=98, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319264, Length=637, Percent_Identity=34.3799058084772, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323182, Length=664, Percent_Identity=34.4879518072289, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319699, Length=527, Percent_Identity=23.719165085389, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=641, Percent_Identity=36.817472698908, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI62472339, Length=548, Percent_Identity=39.2335766423358, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24667959, Length=514, Percent_Identity=38.1322957198444, Blast_Score=330, Evalue=3e-90,
Organism=Drosophila melanogaster, GI21355225, Length=607, Percent_Identity=29.6540362438221, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI21355181, Length=527, Percent_Identity=24.8576850094877, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18859661, Length=532, Percent_Identity=23.6842105263158, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648260, Length=379, Percent_Identity=26.1213720316623, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356947, Length=367, Percent_Identity=25.3405994550409, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72347; Mature: 72347

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKVVGYQWMKPY
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCHHHHHCHHHHHHH
TEVLDLQNGTPFAQWYNGGTCNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEEL
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHH
DSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMT
HHHHHHHHCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFS
HHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQ
CCHHHCCCCCEEHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCC
GDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISP
CCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCH
TLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEI
HHHHHHHHCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCC
SGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
CCCEEECCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHND
HHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHEEEECCC
VIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVED
HHHHHHCCCCCCCCCCEEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVPFIQGLQSSKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFWGEAEKVVGYQWMKPY
CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCHHHHHCHHHHHHH
TEVLDLQNGTPFAQWYNGGTCNVVESVLSRWLADDETRTQPALQYEGENGTSKSFTYEEL
HHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHH
DSWVSRAANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMT
HHHHHHHHCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFS
HHHHCCCEEEEEECCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCC
WSTLEKEKPFVHAEEMHSDDPLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQ
CCHHHCCCCCEEHHHCCCCCCEEEEEECCCCCCCCCCEEECCCCCEEECCCCCCCCCCCC
GDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPKADRLWETVDKYEITHLGISP
CCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHEEEEEECCCH
TLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMWLFETVGKSNVPICNYSGGTEI
HHHHHHHHCCHHHHHHHCCHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEECCCCCCC
SGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWED
CCCEEECCCCCCCCCEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHCC
DERYVNTYWSRFENKWVHGDWVVYDGEQYIITGRSDDTLNIAGKRIGPAEYESILVKHND
HHHHHHHHHHHHCCCEECCCEEEECCCEEEEECCCCCEEEECCCCCCHHHHHHEEEECCC
VIEAAAIGVPDDVKGEVCHCFVVLRDNVTFTGELKKELMSLVNSHIGKALCPKDIHVVED
HHHHHHCCCCCCCCCCEEEEEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
LPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVVPFIQGLQSSKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA