Click here to switch to the map view.

The map label for this gene is Hgd [H]

Identifier: 49185201

GI number: 49185201

Start: 2187929

End: 2188819

Strand: Direct

Name: Hgd [H]

Synonym: BAS2192

Alternate gene names: 49185201

Gene position: 2187929-2188819 (Clockwise)

Preceding gene: 49185200

Following gene: 49185202

Centisome position: 41.84

GC content: 32.66

Gene sequence:

>891_bases
ATGAAAAAGATTGGTTTTATCGGTTTAGGTAACATGGGTCTTCCAATGTCTAAAAATTTAGTTAAATCAAATTACACAGT
ATATGGTGTGGATTTAAATAAAGACGCTGAAGCTTCCTTTGAAAAAGAAGGAGGAATAATTGGCTTATCAATCTCAAAAC
TAGCAGAAACATGCGATGTGATTTTTACAAGTTTACCTTCACCTCGTGCTGTTGAAGCAGTATATTTTGGACAAGAAGGA
TTATTTGAAAATAGTCACTCGAATGTAGTTTTAATAGATACAAGTACTGTATCTCCACAGTTAAACAAACAGTTAGAGGA
AGCTGCAAAGGAAAAGAAAGTAGACTTCTTAGCGGCACCTGTTAGTGGTGGGGTAATTGGAGCTGAAAATCGTACATTAA
CGTTTATGGTTGGTGGATCAAAAGAAGTATATGAAAAAACAGAATCTATCATGGGCGTACTAGGCGCTAACATTTTCCAT
GTTAGTGAGCAAATTGATAGTGGTACAACAGTTAAATTAATTAATAACCTATTAATTGGTTTTTATACAGCTGGTGTGAG
TGAAGCTTTAACGTTAGCGAAAAAGAACAATATGGATTTAGATAAAATGTTTGATATTTTAAATGTAAGTTATGGTCAAA
GTAGAATTTATGAGCGCAATTATAAAAGTTTCATTGCATCAGAAAACTACGAGCCAGGCTTTACTGTAAATTTATTAAAG
AAAGATTTGGGATTTGCAGTTGATTTAGCGAAAGAAAGCGAACTTCACTTACCAGTAAGCGAAATGCTATTAAACGTATA
TGAAGAAGCAAGTGAAGCAGGTTATGGTGAAAATGATATGGCTGCTTTATATAAAAAAGTTAGTGAACAATTAATTTCTA
ATCAAAAATAA

Upstream 100 bases:

>100_bases
TTAGTACCTTTATACACGAACGTATTTACAAAAAAGAGAGAAATTGCGAAAGCTATTATAAATCGCGGAAAGTATATTGT
GTAAATAGGGGGAAAGCGAT

Downstream 100 bases:

>100_bases
TAGATTTATAAACATCATAAAAAAGGAGAGAATATAATGATTACAACTGAAATTAAACGAGTAAAAAATCATATTAATGG
TGAGTGGGTAGAATCTACTG

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKKIGFIGLGNMGLPMSKNLVKSNYTVYGVDLNKDAEASFEKEGGIIGLSISKLAETCDVIFTSLPSPRAVEAVYFGQEG
LFENSHSNVVLIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRTLTFMVGGSKEVYEKTESIMGVLGANIFH
VSEQIDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSFIASENYEPGFTVNLLK
KDLGFAVDLAKESELHLPVSEMLLNVYEEASEAGYGENDMAALYKKVSEQLISNQK

Sequences:

>Translated_296_residues
MKKIGFIGLGNMGLPMSKNLVKSNYTVYGVDLNKDAEASFEKEGGIIGLSISKLAETCDVIFTSLPSPRAVEAVYFGQEG
LFENSHSNVVLIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRTLTFMVGGSKEVYEKTESIMGVLGANIFH
VSEQIDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSFIASENYEPGFTVNLLK
KDLGFAVDLAKESELHLPVSEMLLNVYEEASEAGYGENDMAALYKKVSEQLISNQK
>Mature_296_residues
MKKIGFIGLGNMGLPMSKNLVKSNYTVYGVDLNKDAEASFEKEGGIIGLSISKLAETCDVIFTSLPSPRAVEAVYFGQEG
LFENSHSNVVLIDTSTVSPQLNKQLEEAAKEKKVDFLAAPVSGGVIGAENRTLTFMVGGSKEVYEKTESIMGVLGANIFH
VSEQIDSGTTVKLINNLLIGFYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSFIASENYEPGFTVNLLK
KDLGFAVDLAKESELHLPVSEMLLNVYEEASEAGYGENDMAALYKKVSEQLISNQK

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=32.4324324324324, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI40556376, Length=286, Percent_Identity=28.6713286713287, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI145693186, Length=290, Percent_Identity=34.8275862068965, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1786719, Length=294, Percent_Identity=32.6530612244898, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=30.6338028169014, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790315, Length=287, Percent_Identity=27.8745644599303, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557316, Length=300, Percent_Identity=30, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24655230, Length=289, Percent_Identity=35.2941176470588, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI19922568, Length=289, Percent_Identity=35.2941176470588, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.5551601423488, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 32320; Mature: 32320

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGFIGLGNMGLPMSKNLVKSNYTVYGVDLNKDAEASFEKEGGIIGLSISKLAETCDV
CCCEEEEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCHHHCCCEEEEEHHHHHHHHHH
IFTSLPSPRAVEAVYFGQEGLFENSHSNVVLIDTSTVSPQLNKQLEEAAKEKKVDFLAAP
HHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEC
VSGGVIGAENRTLTFMVGGSKEVYEKTESIMGVLGANIFHVSEQIDSGTTVKLINNLLIG
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCHHEEEHHHCCCCCHHHHHHHHHHH
FYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSFIASENYEPGFTVNLLK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KDLGFAVDLAKESELHLPVSEMLLNVYEEASEAGYGENDMAALYKKVSEQLISNQK
HHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKIGFIGLGNMGLPMSKNLVKSNYTVYGVDLNKDAEASFEKEGGIIGLSISKLAETCDV
CCCEEEEEECCCCCCCCHHHHHCCCEEEEEECCCCCCCCHHHCCCEEEEEHHHHHHHHHH
IFTSLPSPRAVEAVYFGQEGLFENSHSNVVLIDTSTVSPQLNKQLEEAAKEKKVDFLAAP
HHHCCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEC
VSGGVIGAENRTLTFMVGGSKEVYEKTESIMGVLGANIFHVSEQIDSGTTVKLINNLLIG
CCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCHHEEEHHHCCCCCHHHHHHHHHHH
FYTAGVSEALTLAKKNNMDLDKMFDILNVSYGQSRIYERNYKSFIASENYEPGFTVNLLK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
KDLGFAVDLAKESELHLPVSEMLLNVYEEASEAGYGENDMAALYKKVSEQLISNQK
HHCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA