Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 49185200

GI number: 49185200

Start: 2186203

End: 2187912

Strand: Direct

Name: fadE [H]

Synonym: BAS2191

Alternate gene names: 49185200

Gene position: 2186203-2187912 (Clockwise)

Preceding gene: 49185199

Following gene: 49185201

Centisome position: 41.81

GC content: 35.67

Gene sequence:

>1710_bases
ATGGAGAAAACGAAGTTACCGTGGGATGAATTTTTTTCACTTAATAAAGATGTGAAGCATGCTTTCTTTACGCCAGAAGA
TTTTTCAGGAGATGAAGATTTAATCGCAAAAACGACAGAACAATTCGTTAAACAAGAAATTGTTCCACAAATGGAGAATA
TTGAACAACATAACTATAAAGTTTCCCGTCAATTGTTTGAGAAAGCTGGAGAACTTGGATTATTAAGTATCGAGGTCCCA
GAAGAATATGGCGGATTCGAATTAGGAAAGGCAGTTTCAGGGCTTGTAGCAGAAAAAATGGGATACGCTGGTGCATTTAG
CGTTTCATTTAATATACACGCTGGTGTAGGTACATTGCCTTACATATATTACGGAACGAAAGAACAAAAAGAAAAATATT
TGCCGAAAATTGCGTCTGGAGAATGGATTGGAGCTTATGCTTTAACTGAGCCAAATGCCGGTTCTGATGCATTAAGCGCA
AAAACGAGCGCAGTATTGAATGAAGATGGTACTGCTTGGAAGTTAAATGGTGAGAAGCAGTGGATTACAAATGCTCATAT
GGCAGATGTATACGTTGTTTTTGCGAAGACAAATAAAGGAATGACAGCGTTTATTGTCGAAAGAACATGTGAAGGTGTAT
CCATTGGACTAGAAGAAAAGAAAATGGGGATTAAAGGTTCTTCAACGGCTACGCTTATTTTAGAAGATGTTGTTATACCT
GCTGAAAATGTTTTAGGGGAAGTTGGGAAAGGGCATCACGTAGCTCTTAATATTCTTAACTTCGCTAGACTAAAGCTTGC
TTTTGGAAATATTGGAACTGCAAAACAAGCAATTGGATTGTCGGTTCAATATGGAAAAGAGCGAAAACAGTTCCAAACGG
AATTAGTAGATTTTACGATGATTCAAGAGAAAATTGCAAATATGATCATTGCTACATATGGAGCAGAAAGTGCAGCTTAT
CGTACAGCAGGTGTAATTGATGAAGCAATTCATGAGAGTGATGAGGATCTTATGAAGAAAATGTCTCAATTTGCTATTGA
ATGTGCACTGAATAAAGTAAATGCTTCTGAAACATTAGGTCATATCGTAGATGAAGCTGTACAAATTCATGGTGGTTACG
GTTATATGCAAGAATACGAGGTAGAACTATTATATCGTGATGCTAGAATTAGTCGTATTTTTGAAGGAACGAATGAAATT
AATAGATTAACAGTTGCCAAAATGTTAATGAAGCAAATGGAACAAATTGAAGATACTGAAGTAGAGATTGATGTAGCAAA
TGTCGAACGAAATCATCGTTACATTTTATTAGCGAAAAAATTGTTGAAACAATCTTTGAAAACGCTCTCTAAAACTCCAG
GGTTAAAAATTGATCAAGAGCAAGAATATTCACGTGTATTATCTAATATGTTAACGGATGTGTACGTCATGGAATCAGCA
TTTTTACGTACGAGTAAAGCAATTAGTAAAAATGGTGAAGGGAAAGAACGTACGAAACAAATGATAACTGACGTTATTTG
TGAAGAAGGCTATCGTAAAGTAGAAGAAGCGGCGATTTCTATACTTTCAGCGGCTGTTACAGAAGAACAAGATAGGCACG
TAATTTTAGCTGAAATTCGTCAATTATTAGTACCTTTATACACGAACGTATTTACAAAAAAGAGAGAAATTGCGAAAGCT
ATTATAAATCGCGGAAAGTATATTGTGTAA

Upstream 100 bases:

>100_bases
TGAAAAATCATCGCCTTCTGTTTTCAAAAATAAGATATTCCACTCATCGTAGACGTGCATAATTAGTAGCAAGTAAGGCC
GAAATGATAGGGGGATTCAG

Downstream 100 bases:

>100_bases
ATAGGGGGAAAGCGATATGAAAAAGATTGGTTTTATCGGTTTAGGTAACATGGGTCTTCCAATGTCTAAAAATTTAGTTA
AATCAAATTACACAGTATAT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVELLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Sequences:

>Translated_569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVELLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV
>Mature_569_residues
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYKVSRQLFEKAGELGLLSIEVP
EEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLPYIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSA
KTSAVLNEDGTAWKLNGEKQWITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTMIQEKIANMIIATYGAESAAY
RTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLGHIVDEAVQIHGGYGYMQEYEVELLYRDARISRIFEGTNEI
NRLTVAKMLMKQMEQIEDTEVEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIRQLLVPLYTNVFTKKREIAKA
IINRGKYIV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=516, Percent_Identity=35.4651162790698, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI4557235, Length=583, Percent_Identity=32.2469982847341, Blast_Score=267, Evalue=3e-71,
Organism=Homo sapiens, GI76496475, Length=583, Percent_Identity=32.2469982847341, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4557233, Length=402, Percent_Identity=36.5671641791045, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226958412, Length=401, Percent_Identity=33.9152119700748, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI226958414, Length=377, Percent_Identity=34.7480106100796, Blast_Score=209, Evalue=8e-54,
Organism=Homo sapiens, GI4501857, Length=390, Percent_Identity=33.5897435897436, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI4501859, Length=394, Percent_Identity=31.9796954314721, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI187960098, Length=391, Percent_Identity=34.2710997442455, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI4557231, Length=391, Percent_Identity=34.2710997442455, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=29.9212598425197, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI4503943, Length=402, Percent_Identity=30.0995024875622, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI7669494, Length=302, Percent_Identity=33.4437086092715, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI211971008, Length=421, Percent_Identity=25.41567695962, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI48976061, Length=421, Percent_Identity=25.41567695962, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI38505218, Length=410, Percent_Identity=24.6341463414634, Blast_Score=90, Evalue=7e-18,
Organism=Escherichia coli, GI1786223, Length=373, Percent_Identity=27.8820375335121, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI87081958, Length=394, Percent_Identity=26.9035532994924, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87082384, Length=319, Percent_Identity=26.3322884012539, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081702, Length=378, Percent_Identity=23.8095238095238, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=40.4494382022472, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=390, Percent_Identity=32.5641025641026, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=399, Percent_Identity=33.3333333333333, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=398, Percent_Identity=31.6582914572864, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=407, Percent_Identity=32.9238329238329, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71985192, Length=282, Percent_Identity=40.4255319148936, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=388, Percent_Identity=30.1546391752577, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17534899, Length=384, Percent_Identity=31.7708333333333, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=416, Percent_Identity=30.5288461538462, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17534353, Length=399, Percent_Identity=27.5689223057644, Blast_Score=162, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=33.9350180505415, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=37.3949579831933, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=393, Percent_Identity=25.9541984732824, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=287, Percent_Identity=32.404181184669, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=25.3333333333333, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=27.6, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17540912, Length=522, Percent_Identity=24.7126436781609, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=299, Percent_Identity=24.7491638795987, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=299, Percent_Identity=24.7491638795987, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=370, Percent_Identity=27.5675675675676, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321233, Length=360, Percent_Identity=23.6111111111111, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=42.0749279538905, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=34.9614395886889, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI21355753, Length=412, Percent_Identity=33.495145631068, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24646207, Length=395, Percent_Identity=33.1645569620253, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24666513, Length=393, Percent_Identity=32.0610687022901, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI19920834, Length=358, Percent_Identity=30.4469273743017, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24652780, Length=320, Percent_Identity=25.3125, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 63603; Mature: 63603

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
EECCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEEHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVELLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKTKLPWDEFFSLNKDVKHAFFTPEDFSGDEDLIAKTTEQFVKQEIVPQMENIEQHNYK
CCCCCCCHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSRQLFEKAGELGLLSIEVPEEYGGFELGKAVSGLVAEKMGYAGAFSVSFNIHAGVGTLP
HHHHHHHHCCCEEEEEEECCHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCC
YIYYGTKEQKEKYLPKIASGEWIGAYALTEPNAGSDALSAKTSAVLNEDGTAWKLNGEKQ
EEEECCHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
WITNAHMADVYVVFAKTNKGMTAFIVERTCEGVSIGLEEKKMGIKGSSTATLILEDVVIP
EECCCCEEEEEEEEEECCCCCEEEEEECCCCCCEECCHHHHCCCCCCCCEEEEEEHHHCC
AENVLGEVGKGHHVALNILNFARLKLAFGNIGTAKQAIGLSVQYGKERKQFQTELVDFTM
HHHHHHHCCCCCEEEEEHHHHHHHHEEECCCCCHHHHHCCEECCCHHHHHHHHHHHHHHH
IQEKIANMIIATYGAESAAYRTAGVIDEAIHESDEDLMKKMSQFAIECALNKVNASETLG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
HIVDEAVQIHGGYGYMQEYEVELLYRDARISRIFEGTNEINRLTVAKMLMKQMEQIEDTE
HHHHHHHEECCCCCCHHHHHHHHEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCE
VEIDVANVERNHRYILLAKKLLKQSLKTLSKTPGLKIDQEQEYSRVLSNMLTDVYVMESA
EEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FLRTSKAISKNGEGKERTKQMITDVICEEGYRKVEEAAISILSAAVTEEQDRHVILAEIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHH
QLLVPLYTNVFTKKREIAKAIINRGKYIV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]