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The map label for this gene is yhxA [H]

Identifier: 49184534

GI number: 49184534

Start: 1549696

End: 1551045

Strand: Direct

Name: yhxA [H]

Synonym: BAS1519

Alternate gene names: 49184534

Gene position: 1549696-1551045 (Clockwise)

Preceding gene: 49184533

Following gene: 49184535

Centisome position: 29.64

GC content: 38.0

Gene sequence:

>1350_bases
ATGAAAACGAAACAGACTGATGAATTATTAGCAAAAGATGAGCAATATGTTTGGCACGGAATGCGTCCCTTTAGTCCAAA
TAGTACAATGGTAGGGGCAAAAGCAGAAGGGTGCTGGGTTGAAGATATACAAGGGAAAAGATATTTAGATGGCATGAGTG
GTCTTTGGTGTGTGAATAGTGGATATGGAAGAAAAGAGCTCGCAGAGGCGGCATATAAGCAATTACAAACATTATCATAC
TTTCCGATGTCACAATCGCATGAACCCGCTATAAAGCTTGCAGAAAAATTAAATGAGTGGCTTGGAGGGGAGTATGTTAT
TTTCTTCTCTAATAGTGGTTCGGAAGCGAACGAAACAGCTTTTAAAATAGCAAGACAATACTATGCTCAAAAAGGTGAAC
CACATCGTTATAAATTTATGTCACGTTACCGCGGGTATCATGGGAATACAATGGCAACGATGGCAGCGACGGGACAAGCA
CAGCGTAGATATCAATATGAGCCATTTGCTTCAGGATTTTTACATGTGACGCCGCCAGATTGTTATCGTATGCCTGGAAT
AGAAAGAGAGAACATTTATGATGTCGAATGTGTAAAAGAAGTAGATCGGGTCATGACATGGGAATTAAGTGAAACGATTG
CAGCTTTTATTATGGAACCAATTATTACGGGCGGAGGCATTTTAATGCCGCCACAAGACTATATGAAAGCTGTTCATGAA
ACGTGTCAAAAACATGGTGCCTTGCTCATTAGCGATGAAGTAATTTGCGGTTTTGGACGTACAGGAAAGGCATTTGGATT
TATGAATTATGATGTGAAACCAGATATTATTACAATGGCAAAAGGTATTACGAGTGCGTATTTACCATTATCAGCAACAG
CTGTGAAAAGAGAAATATATGAAGCATTTAAAGGAAAAGGAGAATATGAATTCTTCCGTCATATTAATACATTTGGTGGA
AATCCTGCGGCTTGTGCATTAGCACTTAAAAACTTAGAAATTATAGAAAATGAAAATTTAATTGAGCGATCTGCACAAAT
GGGTTCGCTTTTATTAGAGCAATTAAAAGAAGAAATTGGAGAACATCCACTTGTAGGGGATATTAGAGGAAAAGGTCTAC
TAGTTGGAATCGAACTAGTAAATGATAAAGAGACGAAAGAGCCAATTGATAACGACAAAATTGCAAGTGTCGTAAATGCT
TGTAAAGAAAAAGGTTTAATTATAGGGCGGAACGGTATGACAACAGCAGGATATAATAACATCTTGACTTTAGCACCACC
GCTTGTTATTTCAAGTGAAGAAATTGCCTTTGTTATTGGAACGTTGAAGACAGCGATGGAACGTATTTAA

Upstream 100 bases:

>100_bases
TTAATTTTGTGGAATGAAAATAGCAGGGAGAAATTTAAATCATCATGGCACCAGCGCAGCTTTTGTGAAAAATAAGTTGT
TATGGAAGGTGGAAGAAATG

Downstream 100 bases:

>100_bases
TGAATGAAGCGAGCTGTACTATACAGCTCGCTTTTGTTTATGATGTGAAATATGATAAATTTTCAAAGAGAGGGGGGATT
TATTATGAAGAAATATGATT

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI

Sequences:

>Translated_449_residues
MKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI
>Mature_449_residues
MKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=32.3255813953488, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=31.1659192825112, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=33.5697399527187, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI226442705, Length=424, Percent_Identity=33.7264150943396, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=34.0909090909091, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.5462962962963, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=30.8868501529052, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=429, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38679950, Length=429, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38679946, Length=429, Percent_Identity=24.2424242424242, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.7506053268765, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=30.2540415704388, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=30.7125307125307, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=31.1904761904762, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=31.3199105145414, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=27.972027972028, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=25.297619047619, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32564660, Length=463, Percent_Identity=31.7494600431965, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=466, Percent_Identity=30.0429184549356, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=437, Percent_Identity=28.1464530892449, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=30.9278350515464, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=24.0208877284595, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=459, Percent_Identity=30.5010893246187, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=27.8894472361809, Blast_Score=146, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=27.1186440677966, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=32.0185614849188, Blast_Score=214, Evalue=9e-56,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.6279069767442, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21356575, Length=458, Percent_Identity=30.5676855895196, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=28.2758620689655, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366494, Length=385, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667139, Length=385, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667143, Length=385, Percent_Identity=22.8571428571429, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50155; Mature: 50155

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNS
CCCCCHHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEECC
GYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
FKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPD
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCCH
CYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHH
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIY
HHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EAFKGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIG
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHC
EHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNN
CCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC
ILTLAPPLVISSEEIAFVIGTLKTAMERI
EEEECCCEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNS
CCCCCHHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEECC
GYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
FKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPD
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCCH
CYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHH
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIY
HHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EAFKGKGEYEFFRHINTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIG
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHC
EHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNN
CCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC
ILTLAPPLVISSEEIAFVIGTLKTAMERI
EEEECCCEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]