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The map label for this gene is hemY [H]

Identifier: 49184022

GI number: 49184022

Start: 1053083

End: 1054504

Strand: Direct

Name: hemY [H]

Synonym: BAS1001

Alternate gene names: 49184022

Gene position: 1053083-1054504 (Clockwise)

Preceding gene: 49184021

Following gene: 49184024

Centisome position: 20.14

GC content: 41.84

Gene sequence:

>1422_bases
TTGAGGAAAAAAGTTGTAATCATCGGCGGTGGCATCACAGGATTAACAACAATGTATCACTTACAAAAAGATATTCGTGA
CAAGAACTTGCCGATCGATACATTACTGATAGAAGCATCGGGTAAACTTGGCGGGAAAATTCAAACCGTTCGAAAAGATG
GATTTACAATTGAACGCGGACCGGATTCTTTCTTAGCACGAAAAGAAAGTGCAGCTAGATTAGTGAAAGAATTAGGTCTT
GGCGATGAGCTTGTAAATAATCAGGCCGGTCAATCATTTATCCTCGTAAACAATCGGTTACATAAAATGCCGAGCGGATC
AATGATGGGAATTCCAACGCAAATTACGCCGTTTCTATTTTCTGGGCTGTTCTCCCCAATTGGGAAACTAAGAGCTGGTT
TTGATCTATTAATGCCAAGATCAAAACCAGTATCTGACCAATCACTCGGGCACTTTTTCAGACATCGCCTCGGAAATGAA
GTGGTTGAAAATTTAATAGAACCATTACTATCTGGTATTTATGCAGGGGATATTGATGAAATGAGCTTAATGTCAACATT
CCCGCAAATGTATCAAATTGAGCAGAAACATCGCAGTATTTCACTCGGTATGCGTACGCTCGCCCCGAAAGCAGAGAAAG
CTGAACCGAAAAAGGGAATCTTCCAAACAGTGAAAACCGGTTTAGAATCTATCGTAGAATCTCTCGAATTAAAGATGCAT
GAAGGTACGATAATAAAGGGAACTCGCATAGAAAAAGTTGCAAAACAGGGTGATGGCTATGCGATTACTCTTAGTAACGG
AAAAGAAATAGAAGCGGACGCGGTCGTAGTGGCAAGCTCACATAAAGTATTGCCATCTATGTTTGCGCAGTACAAGCAAT
TTCGTTTCTTCCGCAACATTCCATCCACATCAGTTGCGAATGTGGCAATGGCTTTCCCGAAATCAGCCATTCAGCGGGAT
ATTGATGGTACAGGATTTGTTGTCTCTCGAAATAGTGATTACACAATTACAGCATGTACGTGGACGCATAAAAAGTGGCC
ACATACAACGCCAGAAGGAAAAACGCTTCTTCGATGTTACGTTGGACGACCTGGTGATGAAGCGGTTGTAGAACAAACAG
AAGAGGAACTCGTTCAGCTCGTACTAGAAGACTTACGAAAGACGATGGATATTACAGAGGATCCAGAGTTTACAGTCGTA
AGTCGCTGGAAAGAAGCAATGCCCCAATATACAGTAGGCCATAACGAGCGAATGAAGAAACTCACAACATTTATGGAGAA
AGAGTTGCCAGGTATATACTTGGCAGGTAGTTCTTACGCTGGTTCTGGTCTTCCGGACTGTATTGATCAAGGTGAGAAGG
CTGCAAAACGTGTACTCTCTCATTTGGAGAAAGTAATGAATACGGAATTAATCGCACAATAA

Upstream 100 bases:

>100_bases
CCAGAAATGCCAAATGCATCGGACGCATTTATTGACTGTTTAACAGATGTTGTAGTAAAGAAAAAAGAATCTGTAATGTA
AGAAGAAAGGGGGAGCCTGC

Downstream 100 bases:

>100_bases
AGAGAAACGCCTTCAATCATATTGAAGGCGTTTTGTTACTTATTCACCAATAAACATATATAAGTTATTTGGCTTTATAA
CGGCATCTCCTGCATAAATA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPKSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ

Sequences:

>Translated_473_residues
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPKSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ
>Mature_473_residues
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAARLVKELGL
GDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPKSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=493, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI4506001, Length=493, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=8e-40,
Organism=Drosophila melanogaster, GI24649745, Length=467, Percent_Identity=24.8394004282655, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52534; Mature: 52534

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAARLVKELGLGDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNI
CCEEEECCHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCC
PSTSVANVAMAFPKSAIQRDIDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCY
CCHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEE
VGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVVSRWKEAMPQYTVGHNERMKK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKVVIIGGGITGLTTMYHLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAARLVKELGLGDELVNNQAGQSFILVNNRLHKMPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKAEPKKGIFQTVKTGLESIVESLELKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNI
CCEEEECCHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCC
PSTSVANVAMAFPKSAIQRDIDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKTLLRCY
CCHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEE
VGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVVSRWKEAMPQYTVGHNERMKK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLSHLEKVMNTELIAQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]